Ser373
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Home > Phosphorylation Site Page: > Ser373  -  GJA1 (mouse)

Site Information
RAssRAssRPRPDDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459209

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 5 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 ) , astrocyte ( 1 ) , brain ( 5 ) , HaCaT (keratinocyte) ( 4 ) , heart ( 4 ) , HeLa (cervical) ( 3 ) , sertoli-testis ( 2 )

Upstream Regulation
Regulatory protein:
mTOR (mouse) ( 2 ) , SOD1 (mouse) ( 1 ) , THY1 (mouse) ( 1 )
Putative in vivo kinases:
Akt1 (mouse) ( 1 )
Treatments:
Akt_inhibitor_VIII ( 1 , 3 ) , ischemia ( 4 ) , linoleic_acid ( 3 ) , LY294002 ( 1 )

Downstream Regulation
Effects of modification on GJA1:
activity, induced ( 3 ) , intracellular localization ( 2 ) , molecular association, regulation ( 4 ) , phosphorylation ( 4 ) , protein degradation ( 4 ) , ubiquitination ( 4 )
Effects of modification on biological processes:
endocytosis, induced ( 4 )
Induce interaction with:
14-3-3 theta (mouse) ( 4 )

References 

1

Pérez-Núñez R, et al. (2023) Protein kinase B (AKT) upregulation and Thy-1-αβ integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis. J Neuroinflammation 20, 5
36609298   Curated Info

2

Boyer A, et al. (2016) mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biol Reprod 95, 13
27281705   Curated Info

3

Puebla C, et al. (2016) Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. Biochim Biophys Acta 1861, 439-48
26869446   Curated Info

4

Smyth JW, et al. (2014) A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic 15, 684-99
24612377   Curated Info

5

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

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