Ser365
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Home > Phosphorylation Site Page: > Ser365  -  GJA1 (mouse)

Site Information
IVDQRPssRAssRAs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459207

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mass spectrometry ( 2 , 4 , 5 , 6 , 7 , 8 ) , mutation of modification site ( 10 ) , phospho-antibody ( 1 , 3 , 9 , 10 ) , western blotting ( 1 , 3 , 10 )
Relevant cell line - cell type - tissue:
'heart, ventricle' ( 3 ) , brain ( 6 , 8 ) , heart ( 1 , 4 , 6 , 7 , 9 ) , HeLa (cervical) ( 10 ) , MDCK (epithelial) ( 10 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 5 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 2 ) , testis ( 6 )

Upstream Regulation
Phosphatases, in vitro:
PPP3CB (mouse) ( 3 )
Treatments:
angiotensin_2 ( 1 ) , hypoxia ( 9 )

Downstream Regulation
Effects of modification on GJA1:
intracellular localization ( 1 , 10 ) , protein conformation ( 10 )

References 

1

Crassous PA, et al. (2017) Newly Identified NO-Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function. J Am Heart Assoc 6
29269353   Curated Info

2

Li J, et al. (2016) Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Sci Signal 9, rs8
27507650   Curated Info

3

Fontes MS, et al. (2014) Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy. PLoS One 9, e87226
24498049   Curated Info

4

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

5

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Zhou J (2010) CST Curation Set: 9273; Year: 2010; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y)XpS
Curated Info

8

Zhou J (2010) CST Curation Set: 9271; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y)XpS
Curated Info

9

Solan JL, et al. (2007) Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC. J Cell Biol 179, 1301-9
18086922   Curated Info

10

Sosinsky GE, et al. (2007) The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies. Biochem J 408, 375-85
17714073   Curated Info

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