Ser365
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Home > Phosphorylation Site Page: > Ser365  -  GJA1 (human)

Site Information
IVDQRPssRAssRAs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459207

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 4 ) , immunoassay ( 1 , 2 ) , mass spectrometry ( 5 , 6 , 7 , 8 , 9 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 1 , 3 , 8 ) , western blotting ( 1 , 2 , 3 , 8 )
Disease tissue studied:
lung cancer ( 5 , 8 ) , non-small cell lung cancer ( 5 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-'heart, artery' ( 3 ) , 293E (epithelial) ( 6 ) , CL1-0 (pulmonary) ( 8 ) , CL1-1 (pulmonary) ( 8 ) , CL1-2 (pulmonary) ( 8 ) , CL1-5 (pulmonary) ( 8 ) , H2009 (pulmonary) ( 5 ) , H2077 (pulmonary) ( 5 ) , H2887 (pulmonary) ( 5 ) , H322M (pulmonary) ( 5 ) , HCC2279 (pulmonary) ( 5 ) , HCC827 (pulmonary) ( 5 ) , HOP62 (pulmonary) ( 5 ) , HUES-9 ('stem, embryonic') ( 7 ) , LA-25 (fibroblast) ( 1 ) , LCLC-103H (pulmonary) ( 5 ) , MDCK (epithelial) ( 2 ) , NCI-H2172 (pulmonary) ( 5 ) , NCI-H322 (pulmonary) ( 5 ) , NRK (fibroblast) ( 1 ) , TERT20 ('stem, mesenchymal') ( 9 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 4 )
Treatments:
brefeldin_A ( 1 ) , CAIP ( 3 ) , ciclosporin ( 3 ) , low Na ( 3 ) , metastatic potential ( 8 ) , MG132 ( 1 ) , tautomycin ( 3 ) , Tyrode's ( 3 )

Downstream Regulation
Effects of modification on GJA1:
protein conformation ( 4 )

References 

1

Solan JL, Lampe PD (2020) Src Regulation of Cx43 Phosphorylation and Gap Junction Turnover. Biomolecules 10
33255329   Curated Info

2

Cotter ML, et al. (2019) The lipidated connexin mimetic peptide, SRPTEKT-, is a potent inhibitor of Cx43 channels with specificity for the pS368 phospho-isoform. Am J Physiol Cell Physiol
31365296   Curated Info

3

Jabr RI, et al. (2016) Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation: implications for action potential conduction. Pflugers Arch 468, 1945-1955
27757582   Curated Info

4

Grosely R, et al. (2013) Effects of Phosphorylation on the Structure and Backbone Dynamics of the Intrinsically Disordered Connexin43 C-terminal Domain. J Biol Chem 288, 24857-70
23828237   Curated Info

5

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

6

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

7

Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3
21406692   Curated Info

8

Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97
20815410   Curated Info

9

Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313
18578522   Curated Info

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