Ser71
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Home > Phosphorylation Site Page: > Ser71  -  RAC1 (human)

Site Information
yDRLRPLsYPQTDVF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447994

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 4 , 5 ) , western blotting ( 1 , 2 , 4 , 5 )
Disease tissue studied:
colorectal cancer ( 4 ) , colorectal carcinoma ( 4 ) , liver cancer ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 5 ) , Caco-2 (intestinal) ( 4 ) , Huh7 (hepatic) ( 1 ) , MLE12 (epithelial) ( 2 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 2 ) , FAK (human) ( 4 ) , Src (human) ( 4 ) , STMP1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 6 )
Treatments:
2-deoxyglucose ( 3 ) , cyclic_stretch ( 4 ) , ischemia/reperfusion ( 5 ) , NSC23766 ( 4 ) , PP2 ( 4 ) , vanadate ( 5 )

Downstream Regulation
Effects of modification on RAC1:
activity, inhibited ( 6 ) , protein degradation ( 2 )

References 

1

Xie C, et al. (2022) Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis. Cancer Res 82
35544764   Curated Info

2

Zhao J, et al. (2013) SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation. FASEB J 27, 2611-9
23512198   Curated Info

3

Zhong D, et al. (2009) The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R. J Biol Chem 284, 23225-33
19574224   Curated Info

4

Chaturvedi LS, et al. (2007) Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. J Biol Chem 282, 14-28
17088251   Curated Info

5

Zhang QG, et al. (2006) Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury. J Neurochem 98, 1886-98
16831194   Curated Info

6

Kwon T, et al. (2000) Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1. J Biol Chem 275, 423-8
10617634   Curated Info

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