Ser380
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Home > Phosphorylation Site Page: > Ser380  -  p90RSK (rat)

Site Information
HQLFRGFsFVATGLM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447990

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 9 ) , immunoprecipitation ( 7 ) , mutation of modification site ( 7 , 9 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 )
Relevant cell line - cell type - tissue:
'neuron, bipolar' ( 6 ) , 'neuron, cerebellar granule' ( 1 ) , 293 (epithelial) ( 3 , 5 , 7 ) , B82 (fibroblast) ( 3 ) , BHK-21 (fibroblast) ( 8 ) , COS (fibroblast) ( 9 ) , HeLa (cervical) ( 2 ) , vascular smooth muscle cell ('muscle, smooth') ( 4 , 5 )

Upstream Regulation
Regulatory protein:
PKAR1A (mouse) ( 3 )
Putative in vivo kinases:
p90RSK (human) ( 9 )
Treatments:
AG879 ( 6 ) , angiotensin ( 5 ) , BDNF ( 6 ) , colforsin ( 8 ) , EGF ( 2 , 3 ) , GLP-2 ( 8 ) , IL-1b ( 4 ) , mutation ( 2 ) , NSC23766 ( 1 ) , PD98059 ( 4 , 5 , 6 , 9 ) , phorbol_ester ( 8 , 9 ) , Ro31-8220 ( 6 ) , serum ( 7 , 8 ) , TeTx ( 6 ) , U0126 ( 4 , 5 ) , wortmannin ( 6 )

Downstream Regulation
Effects of modification on p90RSK:
activity, induced ( 9 ) , enzymatic activity, induced ( 7 )

References 

1

Stankiewicz TR, et al. (2015) Neuronal Apoptosis Induced by Selective Inhibition of Rac GTPase versus Global Suppression of Rho Family GTPases Is Mediated by Alterations in Distinct Mitogen-activated Protein Kinase Signaling Cascades. J Biol Chem 290, 9363-76
25666619   Curated Info

2

Gao X, Chaturvedi D, Patel TB (2012) Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function. Mol Biol Cell 23, 503-15
22130794   Curated Info

3

Gao X, Chaturvedi D, Patel TB (2010) p90 Ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. J Biol Chem 285, 6970-9
20048145   Curated Info

4

Xu S, Bayat H, Hou X, Jiang B (2006) Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta. Am J Physiol Cell Physiol 291, C1336-45
16822942   Curated Info

5

Douillette A, et al. (2006) The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex. J Biol Chem 281, 13275-84
16513650   Curated Info

6

Gil C, Chaib-Oukadour I, Aguilera J (2003) C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons. Biochem J 373, 613-20
12710887   Curated Info

7

Cavet ME, Lehoux S, Berk BC (2003) 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity. J Biol Chem 278, 18376-83
12618428   Curated Info

8

Yusta B, Estall J, Drucker DJ (2002) Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. J Biol Chem 277, 24896-906
11978789   Curated Info

9

Dalby KN, et al. (1998) Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem 273, 1496-505
9430688   Curated Info