Lys324

Site Information
SAQSrGEkRTAHNAI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 459100

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 ) , modification-specific antibody ( 1 , 2 ) , mutation of modification site ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	liver cancer ( 2 )
Relevant cell line - cell type - tissue:	COS7 (fibroblast) ( 2 ) , HEK293T (epithelial) ( 1 , 2 ) , HeLa (cervical) ( 1 , 2 ) , HepG2 (hepatic) ( 2 ) , liver ( 1 ) , MEF (fibroblast) ( 1 )

Downstream Regulation
Effects of modification on SREBP-1:	protein stabilization ( 1 , 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:	transcription, induced ( 1 , 2 )

References
1	Walker AK, et al. (2010) Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 24, 1403-17 20595232 Curated Info
2	Giandomenico V, Simonsson M, Grönroos E, Ericsson J (2003) Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol Cell Biol 23, 2587-99 12640139 Curated Info