Lys218
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Home > Acetylation Site Page: > Lys218  -  NFkB-p65 (human)

Site Information
EIFLLCDkVQkEDIE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459095

In vivo Characterization
Methods used to characterize site in vivo:
3H acetate labeling ( 4 ) , immunoassay ( 3 ) , immunoprecipitation ( 3 , 4 ) , modification-specific antibody ( 3 ) , mutation of modification site ( 1 , 3 , 4 ) , western blotting ( 3 , 4 )
Disease tissue studied:
glioma ( 1 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
STAT3 (human) ( 3 )
Treatments:
IL-10 ( 3 ) , TNF ( 3 ) , trichostatin_A ( 3 )

Downstream Regulation
Effects of modification on NFkB-p65:
intracellular localization ( 1 , 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 3 ) , transcription, induced ( 1 , 3 )

Disease / Diagnostics Relevance
Relevant diseases:
lung cancer ( 3 )

References 

1

Wollebo HS, et al. (2016) The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. J Neurovirol 22, 615-625
27007123   Curated Info

2

Zhang Y, et al. (2011) AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler Thromb Vasc Biol 31, 2897-908
21940946   Curated Info

3

Lee H, et al. (2009) Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15, 283-93
19345327   Curated Info

4

Chen LF, Mu Y, Greene WC (2002) Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 21, 6539-48
12456660   Curated Info