Lys11
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Home > Acetylation Site Page: > Lys11  -  ubiquitin (human)

Site Information
FVktLTGktItLEVE   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459088

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 3 ) , HeLa (cervical) ( 1 ) , hTERT-RPE1 (epithelial) ( 2 )

Downstream Regulation
Effects of modification on ubiquitin:
molecular association, regulation ( 3 ) , protein degradation ( 3 )
Induce interaction with:
PSMD5 (human) ( 3 ) , ubiquitin (human) ( 3 )

References 

1

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

2

Shang F, et al. (2005) Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem 280, 20365-74
15790562   Curated Info

3

Baboshina OV, Haas AL (1996) Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5. J Biol Chem 271, 2823-31
8576261   Curated Info

4

Zhu DX, et al. (1986) Investigations of primary and secondary structure of porcine ubiquitin. Its N epsilon-acetylated lysine derivative. Int J Biochem 18, 473-6
3011536   Curated Info

5

Jabusch JR, Deutsch HF (1985) Localization of lysines acetylated in ubiquitin reacted with p-nitrophenyl acetate. Arch Biochem Biophys 238, 170-7
2984995   Curated Info

6

Zhu DX, et al. (1985) N-epsilon-acetylation of porcine mature erythrocytes ubiquitin. Int J Biochem 17, 719-21
2993057   Curated Info