Lys186
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Home > Acetylation Site Page: > Lys186  -  FOXO4 (mouse)

Site Information
MLNPDGGkGGkAPRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459042

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , Saos-2 (bone cell) ( 1 )

Upstream Regulation
Treatments:
H2O2 ( 1 ) , LY294002 ( 1 ) , nicotinamide ( 1 ) , resveratrol ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Kobayashi Y, et al. (2005) SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int J Mol Med 16, 237-43
16012755   Curated Info

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