Ser421
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Home > Phosphorylation Site Page: > Ser421  -  DRD1 (rat)

Site Information
EKLSPALsVILDYDt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 30310300

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
soft tissue cancer ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal, CA1 pyramidal' ( 1 ) , HEK293-A (epithelial) ( 1 ) , SK-N-MC (neural crest) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PRKD1 (human) ( 1 )
Kinases, in vitro:
PRKD1 (human) ( 1 )
Treatments:
cocaine ( 1 ) , Tat ( 1 )

Downstream Regulation
Effects of modification on DRD1:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Wang N, et al. (2014) Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacology 39, 1290-301
24362306   Curated Info