Tyr220
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Home > Phosphorylation Site Page: > Tyr220  -  DAB1 (mouse)

Site Information
PETEENIyQVPTSQK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447630

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 4 ) , mass spectrometry ( 4 , 6 ) , mutation of modification site ( 1 , 3 , 4 , 5 , 6 , 7 ) , phospho-antibody ( 1 , 4 , 7 ) , western blotting ( 1 , 2 , 4 , 7 )
Disease tissue studied:
neuroblastoma ( 2 ) , testicular cancer ( 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 3 ) , 'eye, retinal pigmented epithelium' ( 7 ) , 'neuron, cortical' ( 1 ) , 'neuron, cortical'-brain ( 5 ) , 293 (epithelial) ( 6 ) , 293T (epithelial) ( 1 , 2 , 4 , 7 ) , brain ( 4 ) , Neuro-2a (neuron) ( 2 ) , Rat2 (fibroblast) ( 7 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 4 , 8 )
Kinases, in vitro:
Abl (human) ( 7 ) , Src (human) ( 8 )
Treatments:
netrin-1 ( 1 ) , reelin ( 3 , 6 , 8 )

Downstream Regulation
Effects of modification on DAB1:
intracellular localization ( 3 ) , molecular association, regulation ( 2 , 4 , 5 , 6 , 7 )
Effects of modification on biological processes:
cell adhesion, altered ( 5 ) , cell differentiation, induced ( 2 ) , cell growth, altered ( 4 ) , cell motility, altered ( 3 ) , cytoskeletal reorganization ( 7 ) , neural plasticity ( 2 )
Induce interaction with:
CRK (human) ( 4 ) , CRKL (mouse) ( 6 ) , NCK2 (mouse) ( 7 ) , PIK3R1 (human) ( 2 ) , SOCS1 (human) ( 2 ) , Src (human) ( 2 )

References 

1

Zhang JH, et al. (2018) DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons. Cell Rep 22, 3598-3611
29590626   Curated Info

2

Gao Z, et al. (2012) Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions. Mol Cell Biol 32, 2794-808
22586277   Curated Info

3

Morimura T, Ogawa M (2009) Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling. Brain Res 1304, 26-37
19796633   Curated Info

4

Huang Y, et al. (2004) Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins. Biochem Biophys Res Commun 318, 204-12
15110774   Curated Info

5

Sanada K, Gupta A, Tsai LH (2004) Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron 42, 197-211
15091337   Curated Info

6

Ballif BA, et al. (2004) Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol 14, 606-10
15062102   Curated Info

7

Pramatarova A, et al. (2003) Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons. Mol Cell Biol 23, 7210-21
14517291   Curated Info

8

Keshvara L, Benhayon D, Magdaleno S, Curran T (2001) Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J Biol Chem 276, 16008-14
11279201   Curated Info