Thr451
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Home > Phosphorylation Site Page: > Thr451  -  CLOCK (human)

Site Information
AVsDPSStPTKIPTD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 30259800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'brain, forebrain' ( 2 ) , 293 (epithelial) ( 2 ) , HeLa (cervical) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (human) ( 2 )
Kinases, in vitro:
CDK5 (human) ( 2 )

Downstream Regulation
Effects of modification on CLOCK:
intracellular localization ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Kwak Y, et al. (2013) Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. J Biol Chem 288, 36878-89
24235147   Curated Info

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