Tyr200
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Home > Phosphorylation Site Page: > Tyr200  -  DAB1 (mouse)

Site Information
VEDPVyQyIVFEAGH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447960

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
neuroblastoma ( 2 ) , testicular cancer ( 2 )
Relevant cell line - cell type - tissue:
'eye, retinal pigmented epithelium' ( 3 ) , 'neuron, cortical' ( 1 ) , 293T (epithelial) ( 1 , 2 , 3 ) , Neuro-2a (neuron) ( 2 ) , Rat2 (fibroblast) ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell differentiation, induced ( 2 ) , cytoskeletal reorganization ( 3 ) , neural plasticity ( 2 )

References 

1

Zhang JH, et al. (2018) DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons. Cell Rep 22, 3598-3611
29590626   Curated Info

2

Gao Z, et al. (2012) Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions. Mol Cell Biol 32, 2794-808
22586277   Curated Info

3

Pramatarova A, et al. (2003) Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons. Mol Cell Biol 23, 7210-21
14517291   Curated Info