Lys317
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Home > Acetylation Site Page: > Lys317  -  p53 (mouse)

Site Information
sAsPPQkkkPLDGEy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458976

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 , 4 ) , modification-specific antibody ( 2 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 3 , 5 , 6 ) , phospho-antibody ( 2 , 6 , 7 ) , western blotting ( 1 , 2 , 4 , 5 , 6 , 7 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 7 ) , bone marrow ( 4 ) , ES (stem) ( 6 ) , Hep3B (hepatic) ( 1 ) , hepatocyte-liver ( 1 ) , HepG2 (hepatic) ( 1 ) , intestine ( 5 ) , MEF (fibroblast) [PIK3R1 (mouse), homozygous knockout] ( 2 ) , MEF (fibroblast) ( 1 , 5 ) , retinal-retina ( 5 ) , thymocyte ( 3 ) , thymocyte-thymus ( 5 )

Upstream Regulation
Regulatory protein:
HDAC6 (human) ( 1 ) , HDAC6 (mouse) ( 1 ) , PIK3R1 (mouse) ( 2 ) , SETD7 (mouse) ( 4 )
Treatments:
adriamycin ( 5 ) , DEN ( 1 ) , hepatectomy ( 1 ) , high-fat diet ( 1 ) , thioacetamide ( 1 ) , UV ( 6 , 7 ) , UVB ( 2 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, altered ( 3 ) , apoptosis, induced ( 7 ) , apoptosis, inhibited ( 5 ) , cell growth, inhibited ( 1 ) , signaling pathway regulation ( 3 ) , transcription, altered ( 3 , 5 ) , transcription, induced ( 1 , 7 ) , translation, altered ( 3 )

References 

1

Phorl S, et al. (2022) Opposing roles of HDAC6 in liver regeneration and hepatocarcinogenesis. Cancer Sci 113, 2311-2322
35534985   Curated Info

2

Song L, et al. (2011) p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene 30, 1360-71
21057544   Curated Info

3

Jenkins LM, et al. (2008) Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes. Mol Cell Proteomics 7, 716-27
18178582   Curated Info

4

Kurash JK, et al. (2008) Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell 29, 392-400
18280244   Curated Info

5

Chao C, et al. (2006) Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol 26, 6859-69
16943427   Curated Info

6

Chao C, et al. (2000) Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A 97, 11936-41
11035798   Curated Info

7

Chao C, et al. (2000) p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J 19, 4967-75
10990460   Curated Info

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