Lys22
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Home > Acetylation Site Page: > Lys22  -  KPNA2 (human)

Site Information
HRFKNkGkDsTEMRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458963

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , modification-specific antibody ( 4 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 1 , 4 )
Disease tissue studied:
bladder cancer ( 1 ) , bone cancer ( 4 ) , colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
peptide_antagonist ( 4 ) , trichostatin_A ( 4 )

Downstream Regulation
Effects of modification on KPNA2:
activity, induced ( 3 ) , intracellular localization ( 3 ) , molecular association, regulation ( 3 , 4 )
Induce interaction with:
HuR (human) ( 3 )

References 

1

Guo J, et al. (2016) Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder. Oncotarget 7, 45249-45262
27303922   Curated Info

2

Zou T, et al. (2008) Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. Biochem J 409, 389-98
17919121   Curated Info

3

Wang W, et al. (2004) AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem 279, 48376-88
15342649   Curated Info

4

Bannister AJ, Miska EA, Görlich D, Kouzarides T (2000) Acetylation of importin-alpha nuclear import factors by CBP/p300. Curr Biol 10, 467-70
10801418   Curated Info