Lys1024
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Home > Acetylation Site Page: > Lys1024  -  p300 (human)

Site Information
TELkTEIkEEEDQPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458945

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Treatments:
nicotinamide ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on p300:
activity, inhibited ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Bouras T, et al. (2005) SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 280, 10264-76
15632193   Curated Info