Lys1020
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Home > Acetylation Site Page: > Lys1020  -  p300 (human)

Site Information
EERSTELkTEIkEEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458944

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 2 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Treatments:
nicotinamide ( 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on p300:
activity, inhibited ( 2 )
Effects of modification on biological processes:
transcription, inhibited ( 2 )

References 

1

Black JC, et al. (2008) The SIRT2 deacetylase regulates autoacetylation of p300. Mol Cell 32, 449-55
18995842   Curated Info

2

Bouras T, et al. (2005) SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 280, 10264-76
15632193   Curated Info