Lys471
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.8.0
Powered by Cell Signaling Technology
Home > Acetylation Site Page: > Lys471  -  Myb (human)

Site Information
PrtPtPFkHALAAQE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458941

In vivo Characterization
Methods used to characterize site in vivo:
[14C] acetate labeling ( 5 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
leukemia ( 2 ) , chronic myelogenous leukemia ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 5 ) , Jurkat (T lymphocyte) ( 1 , 4 ) , K562 (erythroid) ( 2 ) , liver ( 3 ) , MV4-11 (macrophage) ( 4 )

Upstream Regulation
Treatments:
MS275 ( 4 ) , vorinostat ( 4 )

Downstream Regulation
Effects of modification on Myb:
molecular association, regulation ( 5 )
Effects of modification on biological processes:
transcription, induced ( 5 )
Induce interaction with:
DNA ( 5 )

References 

1

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

2

Moritz A (2010) CST Curation Set: 9820; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

3

Zhao S, et al. (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-4
20167786   Curated Info

4

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

5

Tomita A, et al. (2000) c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. Oncogene 19, 444-51
10656693   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.