Lys49
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Home > Acetylation Site Page: > Lys49  -  CTNNB1 (human)

Site Information
TAPsLsGkGNPEEED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458938

In vivo Characterization
Methods used to characterize site in vivo:
[14C] acetate labeling ( 6 ) , immunoprecipitation ( 5 , 6 ) , modification-specific antibody ( 2 , 5 ) , mutation of modification site ( 5 , 6 ) , western blotting ( 2 , 5 , 6 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
DBC1 (human) ( 2 ) , PKCA (human) ( 5 )
Treatments:
virus infection ( 5 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 5 , 6 ) , molecular association, regulation ( 2 ) , protein stabilization ( 6 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 6 ) , cell motility, induced ( 6 ) , transcription, induced ( 2 , 6 ) , transcription, inhibited ( 5 )
Induce interaction with:
LEF-1 (human) ( 2 )

References 

1

Hoffmeyer K, Junghans D, Kanzler B, Kemler R (2017) Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency. Cell Rep 18, 2815-2824
28329675   Curated Info

2

Yu EJ, et al. (2016) Positive regulation of β-catenin-PROX1 signaling axis by DBC1 in colon cancer progression. Oncogene 35, 3410-8
26477307   Curated Info

3

Iaconelli J, et al. (2015) HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. ACS Chem Biol 10, 883-90
25546293   Curated Info

4

Schofield AV, Gamell C, Bernard O (2013) Tubulin polymerization promoting protein 1 (TPPP1) increases β-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells. Biochem Biophys Res Commun 436, 571-7
23727580   Curated Info

5

Zhu J, Coyne CB, Sarkar SN (2011) PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J 30, 4838-49
21952047   Curated Info

6

Ge X, et al. (2009) PCAF acetylates {beta}-catenin and improves its stability. Mol Biol Cell 20, 419-27
18987336   Curated Info

7

Li Y, et al. (2008) HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem 283, 12686-90
18356165   Curated Info