Ser515
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Home > Phosphorylation Site Page: > Ser515  -  DNMT1 (mouse)

Site Information
MQEKIYIsKIVVEFL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458936

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phosphoamino acid analysis ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on DNMT1:
enzymatic activity, induced ( 1 ) , protein conformation ( 1 )

References 

1

Goyal R, et al. (2007) Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics 2, 155-60
17965600   Curated Info

2

Glickman JF, Pavlovich JG, Reich NO (1997) Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation. J Biol Chem 272, 17851-7
9211941   Curated Info