Ser364
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Home > Phosphorylation Site Page: > Ser364  -  ADRB2 (human)

Site Information
NGNtGEQsGYHVEQE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458915

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 , 4 )

Upstream Regulation
Treatments:
isoproterenol ( 2 , 3 ) , racepinefrine ( 4 )

Downstream Regulation
Effects of modification on ADRB2:
molecular association, regulation ( 2 ) , receptor desensitization, altered ( 3 , 4 ) , receptor internalization, altered ( 2 , 4 )
Induce interaction with:
ARRB2 (human) ( 2 )

References 

1

Gimenez LE, et al. (2012) Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors. J Biol Chem 287, 9028-40
22275358   Curated Info

2

Krasel C, et al. (2008) Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. J Biol Chem 283, 31840-8
18801735   Curated Info

3

Vaughan DJ, et al. (2006) Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem 281, 7684-92
16407241   Curated Info

4

Seibold A, et al. (2000) Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. Mol Pharmacol 58, 1162-73
11040066   Curated Info