Lys157
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Home > Acetylation Site Page: > Lys157  -  Myc (human)

Site Information
AsYQAARkDSGsPNP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458890

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mass spectrometry (in vitro) ( 2 , 3 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
TTC5 (human) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on Myc:
molecular association, regulation ( 3 )
Induce interaction with:
ZBTB17 (human) ( 3 )

References 

1

Lynch JT, et al. (2013) TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death Dis 4, e573
23559008   Curated Info

2

Faiola F, et al. (2005) Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol 25, 10220-34
16287840   Curated Info

3

Zhang K, Faiola F, Martinez E (2005) Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun 336, 274-80
16126174   Curated Info