Ser35
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Home > Phosphorylation Site Page: > Ser35  -  TH iso4 (human)

Site Information
AIMVRGQsPRFIGRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448544

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (human) ( 3 ) , ERK1 (human) ( 2 )

Downstream Regulation
Effects of modification on TH iso4:
enzymatic activity, induced ( 2 )

References 

1

Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW (2009) Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35. Biochim Biophys Acta 1793, 1860-7
19833152   Curated Info

2

Sutherland C, et al. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem 217, 715-22
7901013   Curated Info

3

Le Bourdellès B, et al. (1991) Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing. J Biol Chem 266, 17124-30
1680128   Curated Info

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