Tyr449
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Home > Phosphorylation Site Page: > Tyr449  -  DRP1 (human)

Site Information
IIQHCSNySTQELLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 297110001

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 1 )
Kinases, in vitro:
Abl (human) ( 1 )

Downstream Regulation
Effects of modification on DRP1:
activity, induced ( 1 )

References 

1

Zhou L, et al. (2017) c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death Dis 8, e3117
29022905   Curated Info

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