Tyr179

Site Information
RLLtMSFyRNYHAMT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 458807

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	COS (fibroblast) ( 1 , 2 , 4 ) , COS7 (fibroblast) ( 3 ) , RAW/LR5 (macrophage) ( 1 )

Downstream Regulation
Effects of modification on PLD2:	enzymatic activity, induced ( 2 ) , molecular association, regulation ( 1 , 2 , 4 ) , phosphorylation ( 3 )
Effects of modification on biological processes:	cell cycle regulation ( 3 ) , cell growth, altered ( 2 ) , cell motility, altered ( 1 )
Induce interaction with:	GRB2 (human) ( 1 , 2 , 4 )
Inhibit interaction with:	CD45 (human) ( 2 )

References
1	Knapek K, et al. (2010) The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol 30, 4492-506 20647543 Curated Info
2	Henkels KM, et al. (2009) PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 389, 224-8 19715678 Curated Info
3	Di Fulvio M, Frondorf K, Gomez-Cambronero J (2008) Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal 20, 176-85 18006275 Curated Info
4	Di Fulvio M, et al. (2006) The elucidation of novel SH2 binding sites on PLD2. Oncogene 25, 3032-40 16407827 Curated Info