Thr880
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Home > Phosphorylation Site Page: > Thr880  -  HIPK2 (human)

Site Information
QTIVIPDtPsPTVSV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 29668000

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
HIPK2 (human) ( 1 )
Kinases, in vitro:
HIPK2 (human) ( 1 )
Treatments:
adriamycin ( 1 )

Downstream Regulation
Effects of modification on HIPK2:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein conformation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )
Induce interaction with:
PIN1 (human) ( 1 )

References 

1

Bitomsky N, et al. (2013) Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proc Natl Acad Sci U S A 110, E4203-12
24145406   Curated Info