Ser366
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Home > Phosphorylation Site Page: > Ser366  -  GRB14 (human)

Site Information
GCSsQSIsPMRsIsE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 29576856

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , mass spectrometry (in vitro) ( 1 ) , microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 ) , liver cancer ( 4 )
Relevant cell line - cell type - tissue:
breast ( 2 , 3 ) , COS7 (fibroblast) ( 1 , 4 ) , HepG2 (hepatic) ( 4 ) , S.cerevisiae ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3A (human) ( 1 ) , GSK3B (human) ( 4 )
Kinases, in vitro:
CK2A1 (human) ( 4 ) , GSK3A (human) ( 1 ) , GSK3B (human) ( 1 , 4 )
Treatments:
GSK-3_inhibitor_IX ( 4 ) , insulin ( 4 ) , ischemia ( 3 )

Downstream Regulation
Effects of modification on GRB14:
molecular association, regulation ( 1 , 4 ) , phosphorylation ( 4 )
Inhibit interaction with:
INSR (human) ( 1 , 4 )

References 

1

Taira J, et al. (2017) Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor. J Biochem 162, 113-122
28130417   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Taira J, Higashimoto Y (2014) Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor. J Biochem 155, 353-60
24535599   Curated Info

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