Thr308
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Site Information
KDGAtMKtFCGtPEy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447856

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 121 , 188 , 197 ) , flow cytometry ( 25 , 38 , 103 ) , immunoassay ( 18 , 71 ) , immunoprecipitation ( 35 , 38 , 49 , 57 , 70 , 113 , 199 ) , mass spectrometry ( 39 , 41 , 62 , 64 ) , mutation of modification site ( 21 , 70 , 93 , 159 , 165 , 168 , 188 , 190 , 191 , 199 ) , phospho-antibody ( 11 , 12 , 15 , 16 , 17 , 18 , 19 , 20 , 22 , 24 , 25 , 27 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 177 , 178 , 179 , 180 , 182 , 183 , 184 , 185 , 186 , 187 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 ) , phosphoamino acid analysis ( 136 ) , phosphopeptide mapping ( 197 ) , western blotting ( 11 , 12 , 15 , 16 , 17 , 19 , 20 , 22 , 24 , 27 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , 45 , 47 , 48 , 49 , 50 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 141 , 142 , 143 , 144 , 146 , 147 , 148 , 149 , 150 , 157 , 158 , 160 , 163 , 164 , 165 , 167 , 168 , 170 , 174 , 177 , 179 , 180 , 183 , 185 , 186 , 187 , 189 , 190 , 195 , 196 , 197 , 198 , 199 )
Disease tissue studied:
bone cancer ( 76 ) , glioma ( 22 ) , breast cancer ( 20 , 37 , 87 , 196 ) , breast adenocarcinoma ( 87 ) , colorectal cancer ( 76 , 93 ) , colorectal carcinoma ( 76 , 93 ) , kidney cancer ( 59 ) , leukemia ( 65 ) , liver cancer ( 44 , 122 ) , hepatocellular carcinoma ( 44 ) , lung cancer ( 93 ) , non-small cell lung cancer ( 93 ) , neuroblastoma ( 39 , 183 ) , pancreatic cancer ( 93 ) , pancreatic carcinoma ( 93 ) , multiple myeloma ( 179 ) , fibrosarcoma of soft tissue ( 179 , 190 ) , schizophrenia ( 170 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 47 ) , 'brain, cerebral cortex' ( 146 , 170 ) , 'brain, embryonic' [BAG1 (mouse)] ( 153 ) , 'brain, hippocampus' ( 102 , 146 ) , 'brain, nucleus accumbens' ( 40 ) , 'brain, striatum' ( 146 , 155 ) , 'fat, brown'-'fat, brown' ( 96 ) , 'muscle, skeletal' ( 17 , 30 , 57 , 80 , 95 , 96 , 114 , 118 , 126 , 127 , 132 , 139 , 140 , 163 , 173 ) , 'muscle, skeletal' [CAMKK1 (mouse)] ( 133 ) , 'muscle, skeletal' [DNAPK (mouse), homozygous knockout] ( 123 ) , 'muscle, skeletal' [RICTOR (mouse), homozygous knockout] ( 112 , 129 ) , 'neuron, cortical' ( 66 ) , 'neuron, cortical'-brain ( 39 , 180 , 182 ) , 'neuron, hippocampal' ( 66 ) , 'neuron, striatal' ( 27 ) , 'neuron, superior cervical ganglion' ( 125 ) , 'renal, podocyte' ( 92 ) , 'stem, embryonic' ( 126 ) , 'stem, mesenchymal' ( 69 ) , 293 (epithelial) ( 35 , 56 , 71 , 85 , 101 , 105 , 148 , 175 , 191 , 197 , 199 ) , 32D (myeloid) ( 57 ) , 3T3 (fibroblast) [INSR (human)] ( 197 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 157 , 159 , 161 , 184 , 185 , 189 , 191 , 192 , 194 ) , 3T3 (fibroblast) ( 24 , 94 , 108 , 109 , 116 , 136 , 187 ) , 3T3-L1 (fibroblast) ( 104 , 149 ) , 4T1 (breast cell) ( 196 ) , 786-O (renal) ( 59 ) , A431 (epithelial) ( 93 ) , A549 (pulmonary) ( 93 ) , adipocyte ( 137 ) , adipocyte-adipose tissue ( 56 ) , adipose tissue ( 17 , 57 , 126 , 158 ) , adipose tissue [DNAPK (mouse), homozygous knockout] ( 123 ) , adipose tissue [RICTOR (mouse), homozygous knockout] ( 112 ) , alpha-TC6 (pancreatic) ( 19 ) , AS-B634 ( 20 ) , AV12 ('neuron, neostriatal') ( 164 ) , B lymphocyte [BCAP (mouse), homozygous knockout] ( 128 ) , B lymphocyte [CD19 (mouse), homozygous knockout] ( 128 ) , B lymphocyte-spleen ( 98 ) , B9 (fibroblast) ( 179 ) , BJMC3879luc2 ( 87 ) , BLMVEC (endothelial) ( 168 ) , BMMC (mast) ( 86 ) , brain ( 58 , 64 , 144 ) , breast [PDK1 (mouse), homozygous knockout] ( 37 ) , C141 (epidermal) ( 188 ) , C2C12 (myoblast) [LIN28A (mouse), transfection] ( 75 ) , C2C12 (myoblast) ( 11 , 16 , 57 , 73 , 111 , 121 , 134 ) , CD4+ (T lymphocyte) ( 15 , 25 ) , CD8+ (T lymphocyte) ( 25 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 195 ) , CHO (fibroblast) [Tau iso8 (human)] ( 143 ) , COS (fibroblast) ( 171 , 178 , 191 ) , CTL-EN (T lymphocyte) ( 130 ) , DLD1 (intestinal) ( 93 ) , E14tg2a ('stem, embryonic') ( 160 ) , embryo ( 64 ) , endothelial ( 124 ) , endothelial-aorta ( 166 ) , epithelial ( 99 ) , epithelial [PIK3R1 (mouse), homozygous knockout] ( 89 ) , ES (stem) ( 48 , 78 , 167 ) , fibroblast ( 21 , 33 ) , fibroblast-embryo [BAG1 (mouse)] ( 153 ) , GD25 (fibroblast) ( 177 ) , GSCs (glial) ( 22 ) , HaCaT (keratinocyte) ( 34 ) , HCCLM3 (hepatic) ( 44 ) , HCT116 (intestinal) ( 76 ) , HCT15 (intestinal) ( 93 ) , heart ( 12 , 62 , 126 , 131 , 172 ) , heart [DNAPK (human), transfection] ( 123 ) , heart [PDHK4 (mouse), homozygous knockout] ( 63 ) , HEK293T (epithelial) ( 113 , 186 , 198 ) , HeLa (cervical) ( 70 , 76 , 83 , 93 , 171 ) , hepatocyte ( 85 ) , hepatocyte-liver ( 122 ) , hepatocyte-liver [TSC1 (mouse), homozygous knockout] ( 79 ) , HepG2 (hepatic) ( 122 , 199 ) , HT-22 (neuron) ( 182 ) , HT-4 (neuron) ( 182 ) , HUVEC (endothelial) ( 124 , 137 ) , JB (epithelial) ( 193 ) , keratinocyte ( 147 ) , keratinocyte-skin ( 145 ) , keratinocyte-skin [IGF1 (mouse)] ( 148 ) , L6 (myoblast) ( 94 ) , liver ( 17 , 57 , 64 , 71 , 84 , 85 , 96 , 106 , 126 , 150 , 163 ) , liver [DNAPK (mouse), homozygous knockout] ( 123 ) , liver [RICTOR (mouse), homozygous knockout] ( 112 ) , lung ( 124 ) , lymphocyte ( 15 , 38 , 41 , 170 ) , lymphocyte-spleen ( 32 , 43 ) , M1 (myeloid) ( 65 ) , macrophage-bone marrow ( 36 , 135 , 174 ) , mast-bone marrow ( 159 ) , MCF-7 (breast cell) ( 20 ) , MEF (fibroblast) [BAG4 (mouse), homozygous knockout] ( 77 ) , MEF (fibroblast) [DEDD (mouse), homozygous knockout] ( 117 ) , MEF (fibroblast) [DNAPK (mouse), homozygous knockout] ( 123 ) , MEF (fibroblast) [IGF1R (mouse)] ( 151 , 156 ) , MEF (fibroblast) [Sin1 (mouse), homozygous knockout] ( 119 ) , MEF (fibroblast) [TMEM55B (mouse), homozygous knockout] ( 115 ) , MEF (fibroblast) ( 35 , 46 , 57 , 59 , 68 , 82 , 83 , 97 , 101 , 105 , 120 , 121 , 138 , 141 , 142 ) , MHCC97-L (hepatic) ( 44 ) , MIA PaCa-2 (pancreatic) ( 93 ) , MLO-Y4 (osteoblast) ( 58 ) , MPC-11 (B lymphocyte) ( 179 ) , myeloid ( 135 ) , myoblast ( 127 , 165 ) , myocyte-heart ( 53 , 54 , 81 ) , N1E-115 (neuron) ( 39 ) , NCI-H1299 (pulmonary) ( 93 ) , Neuro-2a (neuron) ( 183 ) , neuron ( 18 ) , neutrophil ( 55 , 67 ) , NMuMG (epithelial) ( 49 , 196 ) , osteoclast ( 135 ) , pancreas ( 117 ) , PaTu (pancreatic) ( 93 ) , PC3 (prostate cell) ( 191 ) , placenta ( 45 ) , platelet-blood ( 31 , 74 , 169 ) , preadipocyte ( 137 ) , prostate ( 107 ) , SF9 ( 192 ) , skin ( 34 , 162 ) , Swiss 3T3 (fibroblast) ( 186 ) , SYF (fibroblast) ( 91 ) , T lymphocyte ( 103 ) , T lymphocyte-blood ( 110 ) , T lymphocyte-lymph node [PKCT (mouse), homozygous knockout] ( 90 ) , T lymphocyte-spleen [PKCT (mouse), homozygous knockout] ( 90 ) , thymocyte ( 15 ) , U2OS (bone cell) ( 76 ) , UOK-101 (renal) ( 59 ) , uterus ( 154 ) , WEHI-164 (fibroblast) ( 190 )

Upstream Regulation
Regulatory protein:
14-3-3 zeta (mouse) ( 113 ) , Akt2 (mouse) ( 139 ) , Akt3 (mouse) ( 74 ) , APPL (human) ( 57 ) , ASK1 (human) ( 105 ) , ASK1 (mouse) ( 105 ) , ATG5 (mouse) ( 24 ) , BAG1 (mouse) ( 153 ) , BAG4 (mouse) ( 77 ) , BCAP (mouse) ( 128 ) , Brk (human) ( 91 ) , CAMKK1 (mouse) ( 133 ) , caveolin-1 (mouse) ( 78 ) , Cbl-b (human) ( 15 ) , CD19 (mouse) ( 128 ) , CDC42 iso1 (human) ( 136 ) , CDH1 (human) ( 22 ) , CLK2 (human) ( 85 ) , DICER1 (mouse) ( 43 ) , DNAPK (mouse) ( 123 ) , DRP1 (human) ( 11 ) , EGFR (human) ( 22 ) , ERK5 (human) ( 168 ) , FOXO1A (mouse) ( 59 , 137 ) , GILZ (human) ( 65 ) , GPX1 (mouse) ( 163 ) , GRB10 (human) ( 56 ) , ICAM1 (mouse) ( 166 ) , IL6R (human) ( 22 ) , ILK (human) ( 69 ) , ILK (mouse) ( 127 , 174 ) , IRS1 (human) ( 19 , 54 , 57 ) , IRS2 (human) ( 19 , 54 , 57 ) , ITGB1 (mouse) ( 118 ) , JNK1 (mouse) ( 81 ) , K17 (mouse) ( 145 ) , LIMS1 (human) ( 93 ) , LIMS1 (mouse) ( 93 ) , LIN28A (mouse) ( 75 ) , MCF2 (human) ( 136 ) , MEK5 (human) ( 168 ) , Met (human) ( 22 ) , mTOR (mouse) ( 73 ) , Musashi-1 (mouse) ( 42 ) , NFkB-p100 (mouse) ( 35 ) , p70S6K (mouse) ( 73 ) , PDGFRA (human) ( 22 ) , PDHK4 (mouse) ( 63 ) , PDK1 (human) ( 195 ) , PDK1 (mouse) ( 37 , 125 , 126 , 167 ) , PGGT1B (mouse) ( 36 ) , PHB (human) ( 111 ) , PIK3CA (mouse) ( 68 ) , PIK3CG (human) ( 67 ) , PIK3R1 (mouse) ( 89 ) , PKCI (mouse) ( 181 ) , PKCT (mouse) ( 121 ) , PLCB2 (human) ( 67 ) , PPP2CA (human) ( 12 ) , PPP2CA (mouse) ( 116 ) , PPP2CB (mouse) ( 116 ) , PPP2R5B (human) ( 85 ) , PPP2R5B (mouse) ( 116 ) , PPP5C (human) ( 12 ) , PTEN (mouse) ( 39 , 48 , 50 , 120 , 144 ) , RAC1 (human) ( 136 ) , RAP1B (mouse) ( 40 ) , Raptor (mouse) ( 73 ) , RHEB (mouse) ( 73 , 134 ) , RHOA (human) ( 136 , 196 ) , RICTOR (human) ( 101 , 112 ) , RICTOR (mouse) ( 59 , 96 , 101 ) , ROCK1 (mouse) ( 114 ) , SCD (mouse) ( 158 ) , SH3BP2 (mouse) ( 135 ) , SHP-2 (mouse) ( 184 ) , SIGLEC7 (mouse) ( 55 ) , Sin1 (mouse) ( 119 , 141 ) , SMO (mouse) ( 33 ) , syndecan-4 (mouse) ( 124 ) , TCL1A (mouse) ( 198 ) , TMCC3 (human) ( 20 ) , TMEM55B (mouse) ( 115 ) , TSC1 (mouse) ( 79 ) , TSC2 (mouse) ( 134 , 142 , 167 ) , TTC3 (human) ( 109 ) , ZAP70 (human) ( 15 )
Putative in vivo kinases:
ERK1 (mouse) ( 180 ) , P38A (mouse) ( 165 ) , PDK1 (mouse) ( 108 , 121 ) , PIK3CA (human) ( 18 )
Kinases, in vitro:
PDK1 (human) ( 189 , 199 ) , PDK1 (mouse) ( 175 )
Putative upstream phosphatases:
PPP2CA (human) ( 27 , 85 ) , PTEN (mouse) ( 192 )
Phosphatases, in vitro:
PPP2CA (mouse) ( 195 )
Treatments:
acadesine ( 122 ) , acetic acid ( 24 ) , activin ( 179 ) , adiponectin ( 45 , 57 , 134 ) , Akt_inhibitor_VIII ( 58 , 67 ) , alpha-mangostin ( 87 ) , AM251 ( 80 ) , amino_acids ( 94 ) , anti-CD28 ( 110 ) , anti-CD3 ( 15 , 32 , 89 , 90 ) , anti-CD3/CD28 ( 43 ) , anti-IgB ( 128 ) , anti-IgM ( 98 ) , anti-ITGAL ( 110 ) , apomorphine ( 155 ) , AS252424 ( 86 ) , atorvastatin ( 131 ) , axatomy ( 51 ) , BAPTA-AM ( 169 , 187 ) , BDNF ( 39 ) , butaprost ( 86 ) , BX795 ( 24 , 119 ) , BX912 ( 24 ) , calphostin_C ( 69 ) , calyculin_A ( 195 ) , cangrelor ( 169 ) , catalase ( 188 ) , CC260 ( 16 ) , cholera_toxin ( 164 ) , cocaine ( 180 ) , colforsin ( 156 , 194 ) , copanlisib ( 24 ) , culturing_of_cells ( 66 ) , dactolisib ( 59 ) , doconexent ( 183 ) , EGF ( 39 , 77 , 91 , 115 , 141 , 164 , 184 , 194 ) , Epo ( 152 ) , estradiol ( 149 , 154 ) , exercise ( 127 ) , exercise training ( 54 ) , fasting ( 85 , 106 ) , FGF1 ( 182 ) , FGF2 ( 124 , 141 ) , fibrinogen ( 55 ) , fMLP ( 67 ) , fostriecin ( 155 ) , GDNF ( 125 ) , GF109203X ( 169 ) , glucose ( 81 ) , GM-CSF ( 113 , 130 ) , Go_6976 ( 69 , 90 ) , GSK2334470 ( 24 ) , H2O2 ( 188 ) , haloperidol ( 170 ) , high-fat diet ( 56 , 57 , 63 ) , HU-210 ( 80 ) , hypoxia ( 81 ) , hypoxia/reoxygenation ( 81 ) , IBMX ( 156 ) , IC87114 ( 86 ) , ifenprodil ( 27 ) , IgE ( 159 ) , IGF-1 ( 53 , 144 , 147 , 148 , 167 , 190 , 199 ) , IL-22 ( 99 ) , IL-6 ( 99 , 179 ) , IL-7 ( 25 ) , inflammation ( 99 ) , insulin ( 11 , 16 , 17 , 19 , 20 , 39 , 49 , 52 , 54 , 56 , 57 , 63 , 69 , 75 , 79 , 80 , 81 , 84 , 85 , 94 , 95 , 96 , 100 , 104 , 105 , 111 , 112 , 114 , 116 , 118 , 119 , 120 , 121 , 126 , 129 , 132 , 133 , 134 , 136 , 138 , 141 , 157 , 161 , 163 , 164 , 167 , 172 , 175 , 185 , 186 , 187 , 189 , 192 , 193 , 195 , 197 ) , ionizing_radiation ( 123 ) , ipatasertib ( 51 ) , ischemia ( 81 ) , KN-62 ( 95 ) , KU-0063794 ( 41 , 69 ) , L803-mts ( 150 ) , laminar flow ( 168 ) , levamfetamine ( 155 ) , LIF ( 160 ) , linoleic_acid ( 161 ) , long-term_potentiation ( 102 ) , low_cell_density ( 46 ) , LPA ( 186 ) , LPS ( 36 ) , lupeol ( 162 ) , LY294002 ( 69 , 89 , 138 , 144 , 152 , 155 , 165 , 169 , 182 , 186 , 193 , 196 , 197 ) , M-CSF ( 135 ) , meal feeding ( 79 ) , mechanical stress ( 58 , 69 ) , memantine ( 146 ) , metamfetamine ( 27 ) , methyl-beta-cyclodextrin ( 78 ) , miR-143 ( 84 ) , miRNA ( 43 ) , MK-2206 ( 51 ) , muscle contraction ( 95 , 139 ) , NAC ( 188 ) , neurotensin ( 164 ) , normal chow diet ( 57 ) , NVP-BKM120 ( 24 ) , okadaic_acid ( 85 , 155 , 190 ) , palmitate ( 94 , 121 ) , PAR1-activating_peptide ( 169 ) , PAR4-activating_peptide ( 169 ) , PD98059 ( 182 , 193 , 197 ) , PDGF ( 104 , 121 , 141 , 199 ) , PGE2 ( 86 , 92 ) , phorbol_ester ( 67 , 147 , 151 , 162 , 169 ) , physostigmine ( 146 ) , pictilisib ( 24 ) , PIK90 ( 119 ) , pilocarpine ( 146 ) , piroxicam ( 89 ) , PP242 ( 119 ) , progesterone ( 154 ) , PTX ( 86 , 164 ) , PUGNAc ( 100 , 185 ) , QL9_peptide ( 110 ) , quinpirole ( 180 ) , rapamycin ( 41 , 53 , 75 , 79 , 86 , 94 , 101 , 119 , 129 , 134 , 138 , 148 , 157 , 167 ) , refeeding ( 85 , 106 ) , SB202190 ( 193 ) , SB203580 ( 165 ) , serum ( 58 , 75 , 101 , 136 , 141 ) , serum_starvation ( 39 , 75 , 141 ) , serum_withdrawal ( 165 ) , siRNA ( 116 , 125 ) , SKF38393 ( 180 ) , skin aging ( 34 ) , SP600125 ( 81 ) , sphingomyelinase ( 38 ) , sphingosine_1-phosphate ( 50 ) , SR48527 ( 164 ) , SR49711 ( 164 ) , staurosporine ( 183 ) , sulprostone ( 86 ) , TGF-beta ( 43 , 179 , 196 ) , Theophylline ( 131 ) , thrombin ( 74 , 169 ) , TNF ( 142 , 190 ) , Torin1 ( 86 ) , triciribine ( 99 ) , troglitazone ( 143 , 148 ) , U0126 ( 35 , 125 , 131 , 156 , 180 , 182 ) , UV ( 181 , 188 , 193 ) , UVB ( 34 ) , vanadate ( 179 ) , VAT-R ( 17 ) , VPS34-IN1 ( 24 ) , wortmannin ( 39 , 52 , 86 , 94 , 100 , 105 , 136 , 148 , 180 , 186 , 198 ) , Y27632 ( 40 )

Downstream Regulation
Effects of modification on Akt1:
activity, induced ( 190 ) , enzymatic activity, induced ( 21 , 66 , 73 , 169 , 191 , 199 ) , molecular association, regulation ( 70 , 85 ) , phosphorylation ( 85 , 88 ) , protein degradation ( 70 ) , ubiquitination ( 70 )
Effects of modification on biological processes:
apoptosis, altered ( 66 , 191 ) , apoptosis, inhibited ( 115 ) , carcinogenesis, induced ( 20 , 22 ) , cell differentiation, induced ( 73 ) , cell growth, altered ( 99 , 115 ) , cell growth, induced ( 22 , 78 ) , cell motility, induced ( 20 ) , cytoskeletal reorganization ( 115 ) , neural plasticity ( 66 ) , RNA splicing, induced ( 32 ) , signaling pathway regulation ( 24 , 66 , 73 , 96 , 124 ) , transcription, altered ( 17 ) , translation, induced ( 18 )
Induce interaction with:
CHIP (human) ( 70 ) , PPP2CA (human) ( 85 ) , PPP2R5B (mouse) ( 85 )

Disease / Diagnostics Relevance
Relevant diseases:
colonic inflamation ( 89 )

References 

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