Ser438
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Home > Phosphorylation Site Page: > Ser438  -  Kv4.2 (rat)

Site Information
ARIRAAKsGSANAYM   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2906103

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 , 2 ) , CHO (fibroblast) ( 4 ) , COS (fibroblast) ( 4 ) , neuron-'brain, hippocampus' ( 3 ) , oocyte ( 4 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 2 , 4 )
Kinases, in vitro:
CAMK2A (human) ( 4 )
Treatments:
KN-62 ( 2 ) , light ( 3 ) , PG 97-269 ( 1 ) , TBS ( 1 , 2 )

Downstream Regulation
Effects of modification on Kv4.2:
protein stabilization ( 4 )
Effects of modification on biological processes:
neural plasticity ( 1 )

References 

1

Caulino-Rocha A, Rodrigues NC, Ribeiro JA, Cunha-Reis D (2022) Endogenous VIP VPAC Receptor Activation Modulates Hippocampal Theta Burst Induced LTP: Transduction Pathways and GABAergic Mechanisms. Biology (Basel) 11
35625355   Curated Info

2

Rodrigues NC, et al. (2021) Hippocampal CA1 theta burst-induced LTP from weaning to adulthood: Cellular and molecular mechanisms in young male rats revisited. Eur J Neurosci 54, 5272-5292
34251729   Curated Info

3

Labno A, Warrier A, Wang S, Zhang X (2014) Local plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2. PLoS One 9, e84086
24404150   Curated Info

4

Varga AW, et al. (2004) Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. J Neurosci 24, 3643-54
15071113   Curated Info