Ser136
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Home > Phosphorylation Site Page: > Ser136  -  BAD (mouse)

Site Information
PFRGRsRsAPPNLWA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447862

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 52 , 78 , 79 , 80 , 82 ) , electrophoretic mobility shift ( 74 , 79 , 81 , 82 ) , immunoprecipitation ( 18 , 37 , 77 ) , mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 , 9 , 10 , 11 , 14 , 15 , 16 , 17 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 39 , 40 ) , mutation of modification site ( 8 , 13 , 41 , 44 , 52 , 53 , 54 , 56 , 58 , 59 , 63 , 66 , 68 , 70 , 74 , 79 , 80 , 82 ) , peptide sequencing ( 82 ) , phospho-antibody ( 8 , 12 , 18 , 27 , 37 , 38 , 41 , 43 , 44 , 45 , 47 , 49 , 50 , 52 , 53 , 54 , 55 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 81 ) , phosphoamino acid analysis ( 42 ) , phosphopeptide mapping ( 78 , 82 ) , western blotting ( 8 , 12 , 18 , 27 , 37 , 38 , 41 , 42 , 43 , 44 , 52 , 53 , 54 , 57 , 58 , 60 , 63 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 )
Disease tissue studied:
anthrax infection ( 16 ) , breast cancer ( 41 ) , leukemia ( 12 , 53 ) , T cell leukemia ( 53 ) , liver cancer ( 37 ) , ovarian cancer ( 63 ) , prostate cancer ( 38 , 43 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 1 , 2 , 6 ) , 'brain, embryonic' [BAG1 (mouse)] ( 46 ) , 'brain, hippocampus' ( 18 ) , 'fat, brown' ( 17 ) , 293 (epithelial) [Akt1 (human)] ( 79 ) , 293 (epithelial) [BAD (mouse)] ( 79 ) , 293 (epithelial) [Kit (human)] ( 79 ) , 293 (epithelial) [PIK3CA (human)] ( 79 ) , 293 (epithelial) ( 27 , 44 , 66 , 70 , 72 , 77 , 81 ) , 32D (myeloid) [BCR-ABL1 (human), transfection] ( 73 ) , 32D (myeloid) ( 73 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 29 ) , 32Dcl3 (myeloid) ( 29 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 49 , 58 , 81 ) , 3T3 (fibroblast) ( 42 , 76 ) , 3T3-L1 (fibroblast) ( 30 , 31 ) , BaF3 ('B lymphocyte, precursor') ( 47 ) , BHK-21 (fibroblast) [Akt1 (human)] ( 79 ) , BHK-21 (fibroblast) [BAD (mouse)] ( 79 ) , BHK-21 (fibroblast) [Kit (human)] ( 79 ) , BHK-21 (fibroblast) [PIK3CA (human)] ( 79 ) , BLMVEC (endothelial) ( 54 ) , brain ( 10 , 11 , 17 , 20 ) , BW ( 49 ) , C2C12 (myoblast) ( 40 ) , CEF ( 68 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 59 ) , CHO-K1 (fibroblast) ( 70 ) , COS (fibroblast) ( 52 , 56 , 59 , 66 ) , D1 (T lymphocyte) ( 53 ) , Dede (fibroblast) ( 74 ) , DU 145 (prostate cell) ( 38 ) , FDCP-1 (myeloid) ( 13 , 52 , 78 ) , fibroblast-embryo [BAG1 (mouse)] ( 46 ) , fibroblast-lung ( 21 , 22 , 23 , 24 , 25 , 32 , 33 , 34 , 35 , 36 ) , FL5.12 (lymphoid) [BAD (mouse)] ( 82 ) , FL5.12 (lymphoid) ( 58 , 67 ) , heart ( 7 , 17 ) , HEK293-A (epithelial) ( 41 ) , HEK293T (epithelial) ( 71 ) , HeLa (cervical) ( 56 ) , Hepa 1-6 (epithelial) ( 39 ) , HepG2 (hepatic) ( 37 ) , HL-1 (myocyte) [Akt1 (mouse), knockdown, stable lentiviral expression of Akt1 shRNA] ( 3 ) , HL-1 (myocyte) [Akt2 (mouse), knockdown, stable lentiviral expression of Akt2 shRNA] ( 3 ) , HL-1 (myocyte) ( 3 ) , kidney ( 17 ) , liver ( 5 , 17 , 28 ) , LNCaP (prostate cell) ( 43 , 61 ) , lung ( 17 , 60 ) , M1 (myeloid) ( 12 ) , macrophage-bone marrow ( 19 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 19 ) , macrophage-peritoneum ( 9 ) , mammary gland ( 65 ) , MCF-7 (breast cell) ( 41 ) , MDA-MB-231 (breast cell) ( 41 ) , MEF (fibroblast) ( 8 , 27 , 41 ) , MEF (fibroblast) [NRas (mouse), homozygous knockout] ( 75 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 14 ) , MMC (mesangial) ( 57 ) , mpkCCD (renal) ( 26 ) , neuron-'brain, hippocampus' ( 50 ) , NHMC (mesangial) ( 57 ) , pancreas ( 17 ) , PC3 (prostate cell) ( 38 , 64 ) , spleen ( 16 , 17 ) , SW626 (ovarian) ( 63 ) , T lymphocyte-blood ( 45 ) , T lymphocyte-spleen ( 15 ) , T lymphocyte-thymus ( 53 ) , testis ( 17 ) , U2OS (bone cell) [Akt1 (human)] ( 79 ) , U2OS (bone cell) [BAD (mouse)] ( 79 ) , U2OS (bone cell) [GR (human)] ( 55 ) , U2OS (bone cell) [Kit (human)] ( 79 ) , U2OS (bone cell) [PIK3CA (human)] ( 79 )

Upstream Regulation
Regulatory protein:
ASK1 (human) ( 27 ) , BAG1 (mouse) ( 46 ) , BCR-ABL1 (human) ( 73 ) , BRAF (mouse) ( 46 ) , ERK5 (human) ( 54 ) , FLT3 (human) ( 47 ) , FLT3 (mouse) ( 29 ) , GILZ (human) ( 12 ) , GRB10 (mouse) ( 41 ) , IKKB (mouse) ( 8 ) , Kit (human) ( 79 ) , MCF2 (human) ( 42 ) , MEK5 (human) ( 54 ) , NRas (mouse) ( 75 ) , Pim1 (human) ( 38 ) , RAF1 (mouse) ( 41 ) , TCL1A (mouse) ( 71 )
Putative in vivo kinases:
Akt1 (mouse) ( 53 , 63 , 64 , 74 , 80 , 81 ) , Pim1 (human) ( 44 ) , Pim2 (human) ( 44 ) , Pim3 (human) ( 44 ) , PKACA (mouse) ( 74 )
Kinases, in vitro:
Akt1 (human) ( 51 , 69 , 71 , 72 , 79 ) , Akt1 (mouse) ( 74 , 80 , 81 ) , p90RSK (human) ( 51 ) , PAK1 (human) ( 76 ) , Pim1 (human) ( 44 ) , Pim1 (mouse) ( 52 ) , Pim3 (mouse) ( 44 ) , PKACA (cow) ( 66 , 72 ) , PKACA (human) ( 49 ) , PKACA (mouse) ( 62 , 74 )
Putative upstream phosphatases:
PPP2CA (mouse) ( 58 )
Treatments:
aphidicolin ( 49 ) , bisindolylmaleimide ( 77 ) , Ca(2+) ( 64 ) , calyculin_A ( 58 , 73 ) , cAMP_analog ( 37 , 70 ) , cantharidin ( 73 ) , ciclosporin ( 73 ) , cigarette_smoke ( 60 ) , colforsin ( 44 , 70 , 72 ) , EGF ( 64 , 72 ) , EGTA ( 64 ) , FL ( 47 ) , fostriecin ( 58 ) , glucose ( 57 ) , Go_6976 ( 77 ) , Go_6983 ( 77 ) , IBMX ( 70 , 72 ) , IGF-1 ( 57 , 72 , 74 ) , IL-2 ( 45 ) , IL-3 ( 47 , 52 , 67 , 80 , 82 ) , IL-3_withdrawal ( 58 , 73 ) , IL-7 ( 53 ) , insulin ( 2 , 6 , 27 ) , laminar flow ( 54 ) , LY294002 ( 53 , 57 , 80 , 81 ) , lycopene ( 60 ) , MK-2206 ( 2 , 6 ) , nocodazole ( 49 ) , okadaic_acid ( 49 , 58 ) , PD98059 ( 77 , 81 ) , PDGF ( 81 ) , phorbol_ester ( 37 , 72 , 77 , 82 ) , rapamycin ( 81 ) , SCF ( 79 ) , serum ( 42 , 54 ) , serum_withdrawal ( 52 ) , staurosporine ( 37 , 49 , 82 ) , taxol ( 49 , 63 ) , TNF ( 8 , 75 ) , wortmannin ( 27 , 50 , 57 , 63 , 79 , 80 , 81 )

Downstream Regulation
Effects of modification on BAD:
activity, induced ( 54 ) , activity, inhibited ( 79 ) , intracellular localization ( 8 , 73 ) , molecular association, regulation ( 18 , 37 , 48 , 58 , 66 , 68 , 73 , 74 , 76 ) , phosphorylation ( 44 )
Effects of modification on biological processes:
apoptosis, altered ( 47 , 53 , 74 ) , apoptosis, inhibited ( 8 , 13 , 54 , 59 , 61 , 66 , 68 , 70 , 73 , 75 , 76 , 81 , 82 ) , cell growth, altered ( 68 )
Induce interaction with:
14-3-3 beta (human) ( 44 , 76 ) , 14-3-3 beta (mouse) ( 58 , 68 , 73 , 74 ) , 14-3-3 theta (mouse) ( 18 ) , 14-3-3 zeta (human) ( 66 ) , PKACA (human) ( 37 ) , PKCA (human) ( 37 ) , PPP2CA (human) ( 37 )
Inhibit interaction with:
Bcl-2 (human) ( 76 ) , Bcl-xL (human) ( 44 , 76 ) , JNK1 (human) ( 48 )

References 

1

Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36
27681418   Curated Info

2

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

3

Reinartz M, Raupach A, Kaisers W, Gödecke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. J Proteome Res 13, 4232-45
25162660   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

6

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

7

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

8

Yan J, et al. (2013) Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell 152, 304-15
23332762   Curated Info

9

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

10

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

11

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

12

Joha S, et al. (2012) GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells. Oncogene 31, 1419-30
21804606   Curated Info

13

Hojabrpour P, et al. (2012) CaMKII-γ mediates phosphorylation of BAD at Ser170 to regulate cytokine-dependent survival and proliferation. Biochem J 442, 139-49
22103330   Curated Info

14

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

15

Navarro MN, et al. (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12, 352-61
21399638   Curated Info

16

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

17

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

18

Kim YS, et al. (2010) Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death. Epilepsy Res 92, 30-40
20813501   Curated Info

19

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

20

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

21

Guo A (2010) CST Curation Set: 9813; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

22

Guo A (2010) CST Curation Set: 9810; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

23

Guo A (2010) CST Curation Set: 9809; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

24

Guo A (2010) CST Curation Set: 9811; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

25

Guo A (2010) CST Curation Set: 9812; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

26

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

27

Seong HA, Jung H, Ichijo H, Ha H (2010) Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. J Biol Chem 285, 2397-414
19920149   Curated Info

28

Guo A (2009) CST Curation Set: 8486; Year: 2009; Biosample/Treatment: tissue, liver/Metformin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

29

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

30

Guo A (2009) CST Curation Set: 7450; Year: 2009; Biosample/Treatment: cell line, 3T3-L1/control; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

31

Guo A (2009) CST Curation Set: 7451; Year: 2009; Biosample/Treatment: cell line, 3T3-L1/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

32

Guo A (2009) CST Curation Set: 6843; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

33

Guo A (2009) CST Curation Set: 6840; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

34

Guo A (2009) CST Curation Set: 6839; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

35

Guo A (2009) CST Curation Set: 6841; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

36

Guo A (2009) CST Curation Set: 6842; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

37

Roy SS, et al. (2009) Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell 33, 377-88
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38

Hu XF, et al. (2009) PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis. J Clin Invest 119, 362-75
19147983   Curated Info

39

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

40

Possemato A (2008) CST Curation Set: 5237; Year: 2008; Biosample/Treatment: cell line, C2C12/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

41

Kebache S, et al. (2007) Grb10 and active Raf-1 kinase promote Bad-dependent cell survival. J Biol Chem 282, 21873-83
17535812   Curated Info

42

Morley S, et al. (2007) Requirement for Akt-mediated survival in cell transformation by the dbl oncogene. Cell Signal 19, 211-8
16916597   Curated Info

43

Chao OS, Clément MV (2006) Epidermal growth factor and serum activate distinct pathways to inhibit the BH3 only protein BAD in prostate carcinoma LNCaP cells. Oncogene 25, 4458-69
16767165   Curated Info

44

Macdonald A, et al. (2006) Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol 7, 1
16403219   Curated Info

45

Li L, et al. (2005) CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106, 3068-73
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46

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16116448   Curated Info

47

Yang X, et al. (2005) The FLT3 Internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112. Cancer Res 65, 7338-47
16103085   Curated Info

48

Sunayama J, Tsuruta F, Masuyama N, Gotoh Y (2005) JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol 170, 295-304
16009721   Curated Info

49

Hashimoto A, Hirose K, Iino M (2005) BAD detects coincidence of G2/M phase and growth factor deprivation to regulate apoptosis. J Biol Chem 280, 26225-32
15901741   Curated Info

50

Watson K, Fan GH (2005) Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways. Mol Pharmacol 67, 757-65
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51

Klumpp S, et al. (2004) Protein kinase CK2 phosphorylates BAD at threonine-117. Neurochem Int 45, 747-52
15234118   Curated Info

52

Aho TL, et al. (2004) Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett 571, 43-9
15280015   Curated Info

53

Li WQ, et al. (2004) Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. J Biol Chem 279, 29160-6
15123689   Curated Info

54

Pi X, Yan C, Berk BC (2004) Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res 94, 362-9
14670836   Curated Info

55

Yan B, et al. (2003) The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem 278, 45358-67
12954615   Curated Info

56

Zhou GL, et al. (2003) Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol 23, 8058-69
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57

Kang BP, et al. (2003) IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose. Am J Physiol Renal Physiol 285, F1013-24
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58

Chiang CW, et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol 23, 6350-62
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59

Cotteret S, Jaffer ZM, Beeser A, Chernoff J (2003) p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol 23, 5526-39
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60

Liu C, et al. (2003) Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res 63, 3138-44
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61

Taghiyev AF, et al. (2003) Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP. Mol Cancer Res 1, 500-7
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62

Donovan N, Becker EB, Konishi Y, Bonni A (2002) JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 277, 40944-9
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63

Mabuchi S, et al. (2002) Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel. J Biol Chem 277, 33490-500
12087097   Curated Info

64

Tran NL, Adams DG, Vaillancourt RR, Heimark RL (2002) Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J Biol Chem 277, 32905-14
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65

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66

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67

Hirai I, Wang HG (2001) Survival-factor-induced phosphorylation of Bad results in its dissociation from Bcl-x(L) but not Bcl-2. Biochem J 359, 345-52
11583580   Curated Info

68

Maslyar DJ, Aoki M, Vogt PK (2001) The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3. Oncogene 20, 5087-92
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69

Virdee K, Parone PA, Tolkovsky AM (2000) Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival Curr Biol 10, R883
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70

Virdee K, Parone PA, Tolkovsky AM (2000) Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival. Curr Biol 10, 1151-4
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71

Laine J, et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell 6, 395-407
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72

Lizcano JM, Morrice N, Cohen P (2000) Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J 349, 547-57
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73

Salomoni P, Condorelli F, Sweeney SM, Calabretta B (2000) Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects. Blood 96, 676-84
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74

Datta SR, et al. (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6, 41-51
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75

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76

Schürmann A, et al. (2000) p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20, 453-61
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77

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78

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79

Blume-Jensen P, Janknecht R, Hunter T (1998) The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol 8, 779-82
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80

del Peso L, et al. (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-9
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81

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82

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