Ser179
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Home > Phosphorylation Site Page: > Ser179  -  RAP1B (cow)

Site Information
PGKARKKssCQLL__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451799

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 ) , MEF (fibroblast) ( 1 ) , NCI-H1299 (pulmonary) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 )
Treatments:
H-89 ( 2 ) , NKH_477 ( 2 )

Downstream Regulation
Effects of modification on RAP1B:
activity, inhibited ( 2 ) , intracellular localization ( 2 )
Effects of modification on biological processes:
cell motility, induced ( 2 )
Inhibit interaction with:
RASSF5 (human) ( 2 )

References 

1

Takahashi M, Li Y, Dillon TJ, Stork PJ (2017) Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. J Biol Chem 292, 1449-1461
28003362   Curated Info

2

Takahashi M, et al. (2013) Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration. J Biol Chem 288, 27712-23
23946483   Curated Info