Thr308
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Site Information
kDGAtMKtFCGtPEy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447856
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 257 , 266 , 296 , 316 , 322 , 343 , 369 ) , flow cytometry ( 288 ) , immunoprecipitation ( 20 , 22 , 34 , 45 , 50 , 56 , 70 , 95 , 98 , 105 , 116 , 123 , 151 , 167 , 180 , 196 , 355 ) , mass spectrometry ( 8 , 33 , 40 , 70 , 82 , 83 , 84 , 97 , 102 , 107 , 108 , 124 , 125 , 126 , 127 , 163 , 164 , 165 , 168 , 172 , 182 , 183 , 214 ) , microscopy-colocalization with upstream kinase ( 326 ) , mutation of modification site ( 4 , 5 , 8 , 19 , 34 , 70 , 91 , 178 , 180 , 195 , 205 , 213 , 216 , 230 , 257 , 268 , 276 , 290 , 296 , 322 , 326 , 331 , 348 , 353 , 358 , 367 , 369 ) , peptide sequencing ( 31 , 370 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 52 , 53 , 54 , 55 , 56 , 59 , 60 , 61 , 62 , 64 , 66 , 68 , 70 , 71 , 74 , 75 , 81 , 86 , 89 , 92 , 95 , 98 , 99 , 103 , 105 , 106 , 109 , 111 , 114 , 116 , 119 , 120 , 121 , 122 , 123 , 129 , 130 , 131 , 136 , 138 , 139 , 140 , 142 , 143 , 148 , 149 , 150 , 151 , 152 , 153 , 155 , 156 , 157 , 160 , 161 , 162 , 166 , 167 , 169 , 171 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 181 , 184 , 185 , 186 , 187 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 210 , 211 , 212 , 213 , 216 , 218 , 219 , 220 , 221 , 223 , 224 , 225 , 226 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 248 , 249 , 250 , 251 , 252 , 253 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 318 , 319 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 330 , 331 , 332 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 349 , 350 , 351 , 352 , 353 , 355 , 356 , 357 , 358 , 359 , 360 , 361 , 362 , 364 , 365 , 371 , 372 ) , phosphoamino acid analysis ( 158 , 369 ) , phosphopeptide mapping ( 322 , 369 ) , western blotting ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 37 , 39 , 40 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 52 , 53 , 54 , 55 , 56 , 59 , 60 , 61 , 62 , 64 , 66 , 68 , 70 , 74 , 75 , 81 , 86 , 89 , 91 , 92 , 95 , 98 , 99 , 103 , 105 , 106 , 109 , 111 , 114 , 116 , 119 , 120 , 121 , 122 , 123 , 129 , 130 , 131 , 136 , 138 , 139 , 140 , 142 , 143 , 148 , 149 , 150 , 151 , 152 , 153 , 155 , 156 , 157 , 158 , 160 , 161 , 162 , 166 , 167 , 169 , 171 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 184 , 185 , 186 , 187 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 210 , 211 , 212 , 213 , 216 , 218 , 219 , 220 , 221 , 223 , 224 , 225 , 226 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 250 , 251 , 252 , 253 , 255 , 259 , 265 , 267 , 269 , 271 , 272 , 273 , 275 , 277 , 279 , 280 , 282 , 283 , 285 , 287 , 289 , 293 , 295 , 296 , 298 , 299 , 302 , 303 , 304 , 307 , 308 , 310 , 313 , 315 , 321 , 322 , 324 , 326 , 327 , 328 , 329 , 331 , 332 , 333 , 335 , 338 , 342 , 351 , 352 , 353 , 355 , 356 , 357 , 358 , 359 , 360 , 361 , 362 , 364 , 365 , 370 , 371 , 372 )
Disease tissue studied:
adrenal cancer ( 252 ) , pheochromocytoma ( 252 ) , bone cancer ( 81 , 173 , 187 , 190 , 210 , 233 , 248 , 277 , 321 ) , Ewing's sarcoma ( 210 ) , osteosarcoma ( 248 ) , brain cancer ( 40 , 58 , 129 , 143 , 156 , 173 , 184 , 234 , 239 , 251 , 266 , 357 , 372 ) , astrocytoma ( 266 ) , glioblastoma ( 40 , 58 , 129 , 143 , 173 , 234 , 239 , 251 , 357 ) , glioblastoma multiforme ( 70 , 129 , 184 ) , glioma ( 40 , 58 , 70 , 129 , 143 , 173 , 184 , 234 , 239 , 251 , 357 ) , Schwannoma ( 156 , 372 ) , breast cancer ( 4 , 13 , 20 , 34 , 36 , 48 , 52 , 61 , 70 , 89 , 106 , 111 , 138 , 140 , 142 , 143 , 167 , 173 , 174 , 186 , 190 , 194 , 200 , 202 , 205 , 206 , 249 , 267 , 269 , 272 , 303 , 327 ) , breast adenocarcinoma ( 89 , 190 ) , HER2 positive breast cancer ( 33 ) , luminal A breast cancer ( 33 ) , luminal B breast cancer ( 33 ) , breast cancer, triple negative ( 33 , 61 , 89 , 190 ) , cervical cancer ( 282 , 298 ) , cervical squamous cell carcinoma ( 298 ) , chondrosarcoma ( 248 ) , colorectal cancer ( 31 , 36 , 71 , 86 , 140 , 160 , 169 , 192 , 328 , 333 ) , colorectal carcinoma ( 31 , 36 , 71 , 86 , 140 , 160 , 169 , 192 , 328 , 333 ) , endometrial cancer ( 3 ) , endometrial adenocarcinoma ( 3 ) , liposarcoma ( 248 ) , gastric cancer ( 32 , 163 , 164 , 273 ) , gastric carcinoma ( 32 , 163 , 164 , 273 ) , kidney cancer ( 91 , 225 , 255 ) , leukemia ( 7 , 24 , 27 , 30 , 60 , 249 , 359 , 360 ) , acute myelogenous leukemia ( 24 , 27 , 30 , 249 , 359 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 249 , 360 ) , chronic lymphocytic leukemia ( 7 ) , chronic myelogenous leukemia ( 24 ) , T cell leukemia ( 7 ) , liver cancer ( 46 , 49 , 50 , 56 , 207 , 237 , 271 ) , liver adenocarcinoma ( 49 ) , hepatocellular carcinoma ( 28 , 46 , 56 ) , lung cancer ( 10 , 15 , 18 , 38 , 82 , 83 , 84 , 109 , 138 , 165 , 173 , 192 , 293 , 347 ) , non-small cell lung cancer ( 10 , 15 , 18 , 21 , 38 , 82 , 84 , 165 , 347 ) , non-small cell lung adenocarcinoma ( 10 , 15 , 18 , 38 , 82 , 83 , 84 , 165 ) , non-small cell large cell lung carcinoma ( 15 , 18 , 84 ) , non-small cell squamous cell lung carcinoma ( 83 , 165 ) , lymphoma ( 19 , 24 , 66 , 121 , 175 , 244 , 249 , 287 , 313 ) , B cell lymphoma ( 5 , 19 ) , Burkitt's lymphoma ( 287 ) , non-Hodgkin's lymphoma ( 19 ) , mantle cell lymphoma ( 19 ) , PEL ( 66 , 121 ) , T cell lymphoma ( 244 ) , malignant fibrous histiocytoma ( 248 ) , neuroblastoma ( 123 , 196 , 234 , 240 ) , ovarian cancer ( 22 , 35 , 140 , 143 , 153 , 156 , 162 , 218 , 303 , 327 ) , ovarian epithelial carcinoma ( 218 ) , pancreatic cancer ( 11 , 21 , 37 , 42 , 95 , 192 , 275 ) , pancreatic carcinoma ( 11 , 37 , 42 , 95 , 192 , 275 ) , pancreatic islet cell cancer ( 21 ) , multiple myeloma ( 9 ) , prostate cancer ( 8 , 50 , 98 , 99 , 105 , 120 , 140 , 143 , 150 , 176 , 190 , 191 , 204 , 206 , 242 , 245 , 253 , 333 , 358 , 361 ) , Kaposi's sarcoma ( 121 ) , melanoma skin cancer ( 177 , 205 ) , fibrosarcoma of soft tissue ( 59 , 333 ) , leiomyosarcoma ( 248 ) , rhabdomyosarcoma ( 210 , 219 , 248 , 307 ) , type 2 diabetes ( 139 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 161 ) , 'macrophage, alveolar'-lung ( 350 ) , 'muscle, skeletal' ( 74 , 136 , 139 , 203 , 219 , 260 , 261 , 265 , 271 , 283 ) , 'muscle, smooth' ( 283 ) , 'neuron, dorsal root ganglion'-brain ( 289 ) , 'stem, embryonic' ( 103 , 155 ) , 'stem, mesenchymal' ( 12 ) , 1-LN (prostate cell) ( 98 ) , 22Rv1 (prostate cell) ( 204 ) , 293 (epithelial) ( 45 , 95 , 119 , 150 , 151 , 157 , 171 , 173 , 181 , 184 , 193 , 199 , 213 , 216 , 230 , 232 , 243 , 252 , 256 , 257 , 258 , 270 , 272 , 280 , 290 , 305 , 310 , 315 , 326 , 329 , 330 , 341 , 344 , 349 , 351 , 364 , 370 ) , 293 (epithelial) [IRS1 (human)] ( 223 ) , 293E (epithelial) ( 321 ) , 293T (epithelial) ( 23 , 34 , 54 , 122 , 180 , 195 , 226 , 268 , 269 , 274 , 333 , 334 ) , 3T3 (fibroblast) ( 50 , 197 , 212 , 216 , 257 , 362 , 367 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 296 , 314 , 324 , 337 ) , 661W ( 152 ) , 786-O (renal) ( 91 ) , A2780 (ovarian) ( 143 , 218 ) , A375 (melanocyte) ( 177 ) , A431 (epithelial) ( 221 , 280 ) , A549 (pulmonary) ( 10 , 15 , 18 , 109 , 173 , 192 , 274 , 293 ) , adipocyte ( 371 ) , adipocyte-adipose tissue ( 29 ) , adipose tissue ( 44 ) , AGS (gastric) ( 32 ) , AML10 (myeloid) ( 30 ) , AML11 (myeloid) ( 30 ) , aorta ( 338 ) , artery-heart ( 246 ) , Aspc1 (pancreatic) ( 42 ) , BAEC (endothelial) ( 199 , 243 , 335 ) , BaF3 ('B lymphocyte, precursor') ( 27 ) , BC3 (B lymphocyte) ( 66 ) , BEAS-2B (epithelial) ( 39 ) , Ben-Men-1 ( 372 ) , BeWo ( 185 ) , BeWo31 ( 185 ) , bile-duct cell-bile-ducts ( 300 ) , Bon1 (pancreatic) ( 21 ) , BPH-1 (epithelial) ( 150 ) , brain ( 234 ) , breast ( 33 ) , breast cell-breast ( 292 ) , BT-474 (breast cell) ( 36 , 89 , 138 , 269 , 281 ) , BT-549 (breast cell) ( 61 , 89 ) , BTIC-12 (glial) ( 58 ) , BTIC-48 (glial) ( 58 ) , C2C12 (myoblast) ( 259 , 283 , 307 ) , C2C12 (myoblast) [SPRY2 (human), transfection] ( 259 ) , C33-A (cervical) ( 282 ) , C4-2 (prostate cell) ( 176 ) , Calu-3 (pulmonary) ( 82 ) , Capan1 (pancreatic) ( 37 ) , CCLP1 (hepatic) ( 300 ) , CD18/HPAF (pancreatic) ( 37 ) , CH27 (squamous) ( 337 ) , CHO (fibroblast) ( 25 , 257 , 285 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 314 ) , CHO (fibroblast) [EPOR (human)] ( 230 ) , CHO (fibroblast) [INSR (human), transfection] ( 353 ) , COS (fibroblast) ( 197 , 200 , 289 , 296 , 322 , 333 , 341 , 345 , 349 , 355 , 365 , 369 ) , CTL-EN (T lymphocyte) ( 302 ) , DF1 (fibroblast) ( 233 ) , DLBCL (B lymphocyte) ( 5 ) , DLD1 (intestinal) ( 169 , 263 ) , DM4 (melanocyte) ( 177 ) , DU 145 (prostate cell) ( 98 , 221 , 361 ) , EA.hy 926 (endothelial) ( 340 ) , embryo ( 233 ) , endothelial-vein ( 348 ) , epithelial-lens ( 148 ) , erythroblast ( 359 ) , ES (stem) ( 252 ) , fibroblast-embryo ( 178 ) , fibroblast-foreskin ( 70 ) , FL5.12 (lymphoid) ( 212 ) , GI-101A (breast cell) ( 303 , 327 ) , glial-brain ( 40 ) , GM0637 (fibroblast) ( 276 ) , GM08391 (fibroblast) ( 276 ) , GM09607 (fibroblast) ( 276 ) , GRANTA-519 (B lymphocyte) ( 19 ) , H2009 (pulmonary) ( 62 ) , HaCaT (keratinocyte) ( 26 , 158 , 312 , 346 ) , HAEC (endothelial) ( 208 , 338 ) , HAK-1A (hepatic) ( 28 ) , HAK-1B (hepatic) ( 28 ) , HBL-100 (breast cell) ( 89 ) , HCC1428 (breast cell) ( 13 ) , HCC15 (pulmonary) ( 83 ) , HCC1500 (breast cell) ( 13 ) , HCC78 (pulmonary) ( 84 ) , HCC827 (pulmonary) ( 82 ) , HCCLM3 (hepatic) ( 46 ) , HCN-2 ('neuron, cortical') ( 179 ) , HCT116 (intestinal) ( 31 , 36 , 86 , 169 , 192 , 263 ) , HCT15 (intestinal) ( 71 ) , HEI-193 (Schwann) ( 156 , 372 ) , HeLa (cervical) ( 17 , 50 , 68 , 70 , 116 , 119 , 130 , 131 , 166 , 182 , 183 , 221 , 228 , 230 , 241 , 274 , 280 , 297 , 304 ) , hematopoietic progenitor-bone marrow ( 236 ) , Hep3B (hepatic) ( 300 ) , hepatocyte-liver ( 4 , 299 ) , HepG2 (hepatic) ( 50 , 207 , 237 , 261 , 271 ) , HEY (ovarian) ( 303 , 327 ) , HGC-27 (gastric) ( 32 ) , HL60 (myeloid) ( 24 , 60 , 309 , 316 , 343 ) , HPB-ALL (T lymphocyte) ( 313 ) , HS294T (melanocyte) ( 177 ) , HT-29 (intestinal) ( 140 , 268 , 274 , 311 , 328 ) , HT1080 (fibroblast) ( 59 , 290 , 333 ) , HuCCT1 (hepatic) ( 300 ) , HUES-1 ('stem, embryonic') ( 16 ) , HUES-7 ('stem, embryonic') ( 16 ) , HUES-9 ('stem, embryonic') ( 16 ) , Huh7 (hepatic) ( 207 ) , HUT-78 (T lymphocyte) ( 244 ) , HUVEC (endothelial) ( 47 , 193 , 285 , 294 , 318 , 331 , 343 , 345 ) , IGROV1 (ovarian) ( 162 ) , IMR32 (neural crest) ( 234 ) , JB (epithelial) ( 295 ) , JEKO-1 (B lymphocyte) ( 19 ) , Jurkat (T lymphocyte) ( 7 , 102 , 124 , 125 , 126 , 127 , 168 , 172 , 214 , 244 , 264 , 286 , 288 , 313 , 337 ) , K562 (erythroid) ( 24 ) , KB (squamous) ( 298 ) , KELLY (neural crest) ( 234 ) , keratinocyte ( 4 ) , KG-1 (myeloid) ( 249 ) , kidney [KLK1 (human)] ( 225 ) , KLE (endometrial) ( 3 ) , L3.6p1 (pancreatic) ( 37 ) , L6 (myoblast) ( 223 , 260 , 370 ) , LAN-1 (neural crest) ( 196 ) , liver ( 6 , 271 ) , LN-Z308 (glial) ( 239 ) , LN229 (glial) ( 129 ) , LNCaP (prostate cell) ( 99 , 143 , 190 , 204 , 242 , 245 , 358 , 361 ) , LOU-NH91 (squamous) ( 83 ) , lung ( 82 , 83 , 84 ) , mammary gland ( 336 ) , MCF-10A (breast cell) ( 140 , 202 , 327 ) , MCF-10A (breast cell) [GAB2 (human), transfection] ( 200 ) , MCF-7 (breast cell) ( 13 , 20 , 70 , 89 , 106 , 167 , 173 , 190 , 194 , 205 , 206 , 221 , 249 , 272 ) , MCF-7 (breast cell) [CYP19A1 (human)] ( 267 ) , MDA-MB-231 (breast cell) ( 4 , 34 , 48 , 52 , 89 , 140 , 142 , 143 , 174 , 186 , 194 , 206 ) , MDA-MB-361 (breast cell) ( 89 ) , MDA-MB-435 (breast cell) ( 89 , 111 ) , MDA-MB-453 (breast cell) ( 89 ) , MDA-MB-468 (breast cell) ( 89 , 190 ) , MEF (fibroblast) ( 45 , 50 , 70 , 131 , 171 , 180 ) , MEF (fibroblast) [Etk (human), heterozygous knockout] ( 92 ) , MEF (fibroblast) [HRas (human)] ( 250 ) , MEF (fibroblast) [IGF1R (mouse)] ( 303 ) , MEF (fibroblast) [p70S6K (mouse), homozygous knockout] ( 155 ) , MEF (fibroblast) [TSC22D2 (human)] ( 221 ) , MEL624 (melanocyte) ( 177 ) , mesangial ( 279 ) , MeWo (melanocyte) ( 177 ) , MHCC97-L (hepatic) ( 46 ) , MIA PaCa (pancreatic) ( 221 ) , MIA PaCa-2 (pancreatic) ( 192 ) , MKN-45 (gastric) ( 163 , 164 , 273 ) , MOLT-4 (T lymphocyte) ( 244 ) , mononuclear ( 238 ) , mononuclear-blood ( 7 ) , MSN (neuron) ( 291 ) , muscle ( 262 ) , MV4-11 (macrophage) ( 27 , 30 ) , NB-4 (myeloid) ( 249 ) , NCI-H157 (pulmonary) ( 268 ) , NCI-H1650 (pulmonary) ( 82 ) , NCI-H1703 (squamous) ( 83 , 165 ) , NCI-H1781 (pulmonary) ( 84 ) , NCI-H1975 (pulmonary) ( 15 , 18 , 38 , 82 ) , NCI-H2073 (pulmonary) ( 83 ) , NCI-H2106 (pulmonary) ( 82 ) , NCI-H2228 (pulmonary) ( 84 ) , NCI-H2342 (pulmonary) ( 83 ) , NCI-H292 (pulmonary) ( 138 ) , NCI-H3122 (pulmonary) ( 84 ) , NCI-H3255 (pulmonary) ( 97 ) , NCI-H345 (pulmonary) ( 284 ) , NCI-H460 (pulmonary) ( 15 , 18 , 221 ) , NCI-H510 (pulmonary) ( 284 ) , NCI-H661 (pulmonary) ( 84 ) , NCI-H69 (pulmonary) ( 284 ) , NCI-H727 (epithelial) ( 21 ) , neuron-'brain, hippocampus' ( 161 ) , neutrophil ( 224 , 308 , 342 , 343 , 351 ) , NL-17 (intestinal) ( 333 ) , NSCLC (pulmonary) ( 347 ) , OAW28 (ovarian) ( 22 ) , OCI-ly7 (B lymphocyte) ( 53 ) , OCI/AML3 (myeloid) ( 30 ) , OK (renal) ( 220 ) , oocyte ( 114 ) , ovary ( 153 ) , OVCAR3 (ovarian) ( 22 , 162 ) , OVCAR5 (ovarian) ( 162 ) , PAE (endothelial) ( 45 , 345 ) , PANC-1 (pancreatic) ( 42 , 192 ) , pancreas ( 42 , 275 ) , PC-12 (chromaffin) ( 252 ) , PC3 (prostate cell) ( 8 , 50 , 98 , 105 , 120 , 140 , 143 , 176 , 191 , 206 , 221 , 253 , 274 , 333 , 361 ) , platelet-blood ( 231 , 301 , 332 , 356 ) , pp126 (keratinocyte) ( 323 ) , QGP-1 (endocrine) ( 21 ) , RAMOS (B lymphocyte) ( 287 ) , Rh1 (bone cell) ( 210 ) , Rh13 (muscle cell) ( 307 ) , Rh18 (muscle cell) ( 210 , 307 ) , Rh30 (muscle cell) ( 210 , 219 , 307 ) , Rh4 (muscle cell) ( 307 ) , Rh41 ( 210 ) , Rh5 (muscle cell) ( 307 ) , RPMI-8226 (plasma cell) ( 9 ) , RWP1 (pancreatic) ( 95 ) , Saos-2 (bone cell) ( 256 ) , SB2 (melanocyte) ( 177 ) , SCC12 (keratinocyte) ( 339 ) , Schwann ( 195 ) , SG231 (hepatic) ( 300 ) , SH-SY5Y (neural crest) ( 123 , 234 , 240 , 305 ) , SHEP (neuron) ( 234 , 291 ) , SK-HEP-1 (endothelial) ( 49 ) , SK-MEL2 (melanocyte) ( 177 ) , SK-MEL28 (melanocyte) ( 43 ) , SK-MEL5 (melanocyte) ( 177 ) , SK-N-MC (neural crest) ( 291 ) , SKBr3 (breast cell) ( 89 , 138 , 281 ) , SKBR7 (breast cell) ( 34 ) , skin ( 26 , 177 ) , SKNBE (neural crest) ( 234 ) , SKNSH (neural crest) ( 234 ) , SKOV-3 (ovarian) ( 35 , 140 , 156 , 162 , 322 ) , SKRC-44 (renal) ( 255 ) , SMMC7721 (hepatocyte) ( 49 ) , SRB-1 (squamous) ( 312 ) , SU-DHL-2 (B lymphocyte) ( 53 ) , Su.86.86 (pancreatic) ( 11 , 42 ) , SUM149 (breast cell) ( 36 ) , SW48 (intestinal) ( 71 ) , SW620 (intestinal) ( 71 ) , SY5Y (neuron) ( 306 ) , T lymphocyte-blood ( 229 ) , T47D (breast cell) ( 13 , 20 , 70 , 89 , 303 ) , T84 (intestinal) ( 160 ) , T98G (glial) ( 70 , 129 ) , TF-1 (erythroid) ( 249 , 360 ) , THP1 (myeloid) ( 24 , 352 ) , U-937 (myeloid) ( 24 , 175 , 249 , 313 ) , U251 (glial) ( 239 , 251 ) , U2OS (bone cell) ( 81 , 173 , 187 , 190 , 233 , 277 ) , U2OS (bone cell) [GR (human)] ( 321 ) , U373 MG (glial) ( 184 ) , U87MG (glial) ( 143 , 173 , 234 , 251 , 266 , 357 ) , UACC-257 (melanocyte) ( 177 ) , UCSD-354L (melanocyte) ( 177 ) , UT-7 (myeloid) [EPO (human), transfection] ( 359 ) , VSMC-aorta ( 149 ) , WI-38 (fibroblast) ( 190 ) , WiDr (epithelial) ( 31 ) , WM-1552 (melanocyte) ( 177 ) , WM1799 (melanocyte) ( 177 ) , WM2664 (melanocyte) ( 177 ) , WM3211 (melanocyte) ( 177 ) , WM35 (melanocyte) ( 177 , 205 ) , WM46 (melanocyte) ( 177 ) , WM793 ( 140 ) , ZR-75-1 (breast cell) ( 89 )

Upstream Regulation
Regulatory protein:
Ack (human) ( 46 ) , ADRA1B (human) ( 320 ) , Akt1 (human) ( 106 , 114 , 140 , 181 , 197 , 211 , 329 , 357 ) , Akt2 (human) ( 181 , 197 ) , AMIGO2 (human) ( 47 ) , BAP28 (human) ( 42 ) , Bcr (human) ( 5 ) , beclin 1 (human) ( 48 ) , BRAF (human) ( 177 ) , Brk (human) ( 105 , 150 ) , CA9 (human) ( 255 ) , CAMKK1 (human) ( 329 ) , CD133 (human) ( 54 ) , CDK1 (human) ( 16 ) , CHKA (human) ( 194 ) , CHKB (human) ( 194 ) , CSF2RB (human) ( 302 ) , CYP3A5 (human) ( 56 ) , DDIT4 (human) ( 270 ) , DDIT4L (human) ( 270 ) , DYRK2 (human) ( 20 ) , Epac1 (human) ( 98 ) , ERK1 (human) ( 230 ) , ERK2 (human) ( 230 ) , Etk (human) ( 92 ) , FKBP5 (human) ( 3 ) , FRK (human) ( 187 ) , GAB2 (human) ( 200 ) , GRB2 (human) ( 149 ) , HER2 (human) ( 89 ) , HER3 (human) ( 162 ) , HRas (human) ( 140 , 278 , 320 , 362 ) , HSP90A (human) ( 213 ) , IEX-1 (human) ( 230 ) , IKKB (human) ( 203 ) , IL2RA (human) ( 229 ) , ILK (human) ( 206 , 251 , 304 , 310 , 361 ) , INPP4B (human) ( 31 ) , INPP5E (human) ( 334 ) , KLK1 (human) ( 225 ) , KRas (human) ( 278 ) , LIMS1 (human) ( 304 ) , LKB1 (human) ( 228 ) , LYN (human) ( 209 ) , MEK1 (human) ( 327 ) , MINK (human) ( 34 ) , MST2 (human) ( 156 ) , mTOR (human) ( 114 , 181 , 208 ) , MYO6 (human) ( 10 ) , NRas (human) ( 177 ) , OSBPL9 (human) ( 232 ) , P130Cas (human) ( 88 ) , p53 (human) ( 190 ) , PAK1 (human) ( 241 ) , PAK1 (rat) ( 197 ) , PAK2 (human) ( 197 , 241 ) , PDK1 (human) ( 171 , 213 , 326 ) , PDK1 (mouse) ( 283 , 353 ) , PHLDA3 (human) ( 190 ) , PHLPP (human) ( 140 , 227 ) , PHLPP2 (human) ( 140 , 227 ) , PIK3CA (human) ( 140 , 202 , 238 ) , PIK3CG (human) ( 289 ) , PIK3R1 (human) ( 8 ) , PINK1 (human) ( 133 ) , PKCB (human) ( 238 ) , PKCT (mouse) ( 91 ) , PKN1 (human) ( 353 ) , PKN2 (human) ( 353 , 355 ) , PPP1CA (human) ( 148 ) , PPP1R2 (human) ( 240 ) , PPP2CA (human) ( 166 , 212 ) , PPP2R2A (human) ( 24 , 37 , 39 ) , PPP2R5B (human) ( 230 ) , PRICKLE1 (human) ( 34 ) , PTEN (human) ( 61 , 233 , 357 , 361 , 362 ) , PTPRJ (human) ( 193 ) , PTPRK (human) ( 54 ) , PXN iso2 (human) ( 169 ) , RAC1 (human) ( 197 ) , Raptor (human) ( 181 ) , RICTOR (human) ( 181 , 191 ) , RRas (human) ( 140 ) , SHIP (human) ( 286 ) , SHIP-2 (human) ( 140 ) , SHIP-2 (mouse) ( 357 ) , SHPS1 (human) ( 149 ) , SPRY2 (human) ( 259 ) , Src (human) ( 211 , 320 ) , ST3GAL5 (human) ( 60 ) , ST8SIA1 (human) ( 60 ) , TACC3 (human) ( 49 ) , TIMP1 (human) ( 62 ) , TRAF6 (human) ( 180 ) , ULK1 (human) ( 226 ) , USP49 (human) ( 11 ) , ZFP57 (human) ( 59 )
Putative in vivo kinases:
AXL (human) ( 25 ) , IKKE (human) ( 118 ) , Mer (human) ( 25 ) , PDK1 (human) ( 50 , 149 , 328 , 333 ) , PRKD1 (human) ( 326 ) , TBK1 (human) ( 135 ) , Tyro3 (human) ( 25 )
Kinases, in vitro:
PDK1 (human) ( 254 , 274 , 333 , 363 , 368 ) , PKCA (human) ( 356 ) , PKCB (human) ( 356 )
Putative upstream phosphatases:
PPP2CA (human) ( 42 , 186 ) , PTEN (human) ( 22 )
Phosphatases, in vitro:
PPP2CA (human) ( 212 ) , PTEN (human) ( 22 )
Treatments:
1-methyladenine ( 114 ) , 2-deoxyglucose ( 298 ) , 4-DAMP ( 99 ) , 4-HT ( 174 , 211 , 326 ) , 5-cholesten-5-beta-ol ( 158 ) , 8-CPT-2Me-cAMP ( 98 ) , 8-Rp-cAMP ( 246 ) , 9cRA ( 174 ) , actinomycin_D ( 155 ) , activin ( 103 ) , ADA ( 224 ) , adiponectin ( 186 , 228 ) , adriamycin ( 180 ) , afatinib ( 38 ) , AG1024 ( 303 ) , AG1296 ( 303 ) , AG1478 ( 133 , 158 , 280 , 303 ) , Akt-I-1 ( 166 , 220 , 282 ) , Akt-I-1,2 ( 282 ) , Akt_inhibitor_VIII ( 151 ) , alpelisib ( 21 ) , alpha-mangostin ( 142 ) , amino_acids ( 260 , 321 ) , angiotensin ( 294 ) , anti-Akt1 ( 269 ) , anti-CD3/CD28 ( 229 ) , anti-E-cadherin ( 323 ) , anti-HER2 ( 281 ) , anti-HLA ( 208 ) , anti-ICAM-2 ( 337 ) , anti-IgM ( 19 , 238 ) , anti-integrin_alpha9beta1 ( 140 ) , anti-PDGFR ( 303 ) , apelin ( 285 ) , arachidonic_acid ( 343 ) , atiprimod ( 237 ) , AZD8055 ( 173 ) , BAPTA-AM ( 253 , 301 , 356 ) , BAR501 ( 63 ) , BCI-121 ( 23 ) , BDNF ( 58 ) , bisindolylmaleimide ( 238 , 356 ) , BQ-123 ( 280 ) , BQ-788 ( 280 ) , bradykinin ( 345 ) , bumetanide ( 235 ) , C2-ceramide ( 353 ) , C6-ceramide ( 35 , 360 ) , caffeine ( 295 ) , calyculin_A ( 140 , 231 , 235 , 246 , 253 , 360 ) , cAMP_analog ( 195 ) , cangrelor ( 301 ) , carbachol ( 99 ) , CAY10399 ( 224 ) , CCCP ( 305 ) , celecoxib ( 300 , 328 ) , cell_adhesion ( 175 ) , CGS_21680 ( 224 ) , cholesterol ( 158 ) , cholesterol_oxidase ( 158 ) , ciclosporin ( 129 , 253 ) , cisplatin ( 180 ) , colforsin ( 195 , 224 , 246 , 349 ) , collagen ( 332 ) , collagen XIX (NC1 domain) ( 43 ) , compound_7 ( 134 ) , conditioned medium ( 30 ) , convulxin ( 332 ) , CTGF ( 279 ) , culturing_of_cells ( 161 , 238 ) , CXCL12 ( 238 , 241 ) , cyclic_stretch ( 280 ) , cycloheximide ( 116 ) , dactolisib ( 202 ) , dasatinib ( 140 ) , decorin ( 340 ) , deoxygenation ( 75 ) , depolarization ( 240 ) , derivative-2 ( 66 ) , dexamethasone ( 174 ) , DMSO ( 202 , 211 ) , dronabinol ( 244 ) , duvelisib ( 30 ) , EF24 ( 218 ) , EGF ( 4 , 10 , 35 , 133 , 150 , 156 , 200 , 227 , 242 , 245 , 255 , 283 , 295 , 303 , 311 , 349 ) , EGTA ( 99 ) , englerin_A ( 91 ) , ephrin_A1 ( 140 , 184 ) , Epo ( 230 , 359 ) , erbstatin ( 338 ) , erlotinib ( 55 ) , estrogen_deprivation ( 267 ) , ethanol ( 140 , 323 ) , exercise training ( 139 ) , fasting ( 74 ) , FGF2 ( 103 , 259 ) , fibronectin ( 86 ) , Filipin ( 158 ) , fingolimod ( 24 , 27 , 313 ) , FL ( 27 ) , fluid_shear_stress ( 335 ) , FMK-MEA ( 71 ) , fMLP ( 224 , 342 , 343 ) , FTI277 ( 278 ) , ganglioside ( 339 ) , gefitinib ( 55 , 97 ) , genistein ( 338 ) , GF109203X ( 285 , 301 ) , GH ( 74 ) , ghrelin ( 117 ) , glabridin ( 109 ) , glucose ( 201 ) , glucose_starvation ( 223 ) , GM-CSF ( 360 ) , Go_6976 ( 356 ) , growth_factor_withdrawal ( 152 ) , GSK2334470 ( 9 , 13 , 50 ) , H-89 ( 224 , 320 ) , H2O2 ( 151 , 152 , 171 , 199 , 235 ) , heat_shock ( 296 , 305 ) , hepatitis C virus expression ( 6 ) , heregulin ( 103 ) , HGF ( 32 , 56 , 69 , 86 , 299 ) , high-fat diet ( 371 ) , HNMPA(AM)3 ( 179 ) , HU-210 ( 317 ) , hypotonic_buffer ( 235 ) , hypoxia ( 185 ) , hypoxia/reoxygenation ( 254 ) , ibrutinib ( 7 , 53 ) , IC87114 ( 224 ) , ICAM-2 ( 337 ) , idelalisib ( 19 ) , IFN-gamma ( 160 ) , IGF-1 ( 48 , 103 , 147 , 149 , 167 , 180 , 210 , 216 , 235 , 258 , 272 , 303 , 304 , 305 , 322 , 347 , 370 ) , IGF-2 ( 59 , 307 ) , IgG ( 323 ) , IL-13 ( 328 ) , IL-1a ( 94 ) , IL-1b ( 180 , 329 ) , IL-3 ( 212 ) , IL-6 ( 261 ) , imatinib ( 140 ) , insulin ( 29 , 116 , 122 , 136 , 139 , 151 , 166 , 181 , 189 , 207 , 221 , 223 , 226 , 228 , 259 , 260 , 261 , 262 , 268 , 271 , 276 , 283 , 294 , 298 , 305 , 314 , 315 , 319 , 321 , 324 , 330 , 338 , 341 , 344 , 353 , 370 , 371 ) , ionomycin ( 99 , 329 ) , IP(6) ( 176 ) , IQA ( 264 ) , isoproterenol ( 320 ) , isosilybin_B ( 204 ) , K252a ( 279 ) , KCl ( 235 ) , KHS101 ( 49 ) , KN-93 ( 99 ) , KP-372-1 ( 249 ) , KP-392 ( 361 ) , LAM ( 352 ) , laminin-1 ( 86 ) , leptin ( 338 ) , linoleic_acid ( 78 ) , losartan ( 280 , 294 ) , LPA ( 303 , 327 ) , LPS ( 44 , 180 , 350 ) , LY294002 ( 69 , 103 , 116 , 140 , 158 , 166 , 167 , 194 , 201 , 216 , 221 , 230 , 236 , 238 , 242 , 244 , 245 , 246 , 257 , 264 , 268 , 280 , 297 , 299 , 301 , 309 , 316 , 317 , 320 , 323 , 326 , 327 , 332 , 338 , 346 , 347 , 350 , 353 , 354 , 356 , 357 , 360 ) , LY333531 ( 238 ) , major_basic_protein ( 308 ) , mastoparan ( 317 ) , methyl-beta-cyclodextrin ( 158 ) , MG132 ( 243 ) , MK-2206 ( 24 , 58 ) , Mn(2+) ( 140 ) , N6-benzoyl-cAMP ( 98 ) , NAC ( 152 ) , naltrindole ( 284 ) , neuregulin ( 162 , 195 ) , neurotrophin-3 ( 58 ) , NGF ( 252 , 306 ) , nicotine ( 293 ) , NS398 ( 273 ) , okadaic_acid ( 42 , 78 , 114 , 116 , 119 , 140 , 152 , 166 , 175 , 186 , 243 , 253 , 268 , 313 , 360 ) , OSU-03012 ( 40 , 219 ) , OSU-T315 ( 372 ) , ouabain ( 220 ) , PAR1-activating_peptide ( 301 ) , PAR4-activating_peptide ( 301 ) , PD0325901 ( 71 ) , PD168393 ( 280 ) , PD98059 ( 140 , 257 , 316 , 327 , 342 ) , PDGF ( 169 , 197 , 216 , 295 , 296 , 303 , 334 , 367 ) , PDK1_inhibitor_3 ( 143 ) , pemetrexed ( 15 , 18 , 36 ) , PGE2 ( 224 ) , phorbol_ester ( 64 , 235 , 236 , 238 , 301 , 315 , 321 , 344 , 356 ) , PI-103 ( 202 ) , PIK-93 ( 202 ) , PIK90 ( 202 ) , pimenta doica ( 52 ) , PKC_inhibitor_myristoylated ( 285 ) , PLS-123 ( 53 ) , PLTP ( 179 ) , PP-110 ( 202 ) , PP1 ( 257 ) , PP2 ( 140 , 193 , 320 ) , PP242 ( 9 , 71 , 147 , 155 , 189 ) , PP30 ( 189 ) , PTP1B_inhibitor ( 122 ) , PTX ( 280 , 285 , 327 ) , PUGNAc ( 106 ) , QLT0254 ( 275 ) , racepinefrine ( 99 , 136 ) , rapamycin ( 28 , 71 , 140 , 147 , 155 , 173 , 205 , 210 , 228 , 257 , 285 , 298 , 321 , 354 ) , resveratrol ( 151 ) , retinoic_acid ( 155 , 174 ) , rimonabant ( 317 ) , Ro31-8220 ( 236 ) , salicylate ( 315 , 354 ) , sardomozide ( 196 ) , SB203580 ( 327 , 351 ) , SCF ( 236 ) , scratch wound ( 75 ) , selenite ( 253 ) , serum ( 180 , 184 , 197 , 202 , 212 , 221 , 239 , 245 , 256 , 295 , 347 , 361 ) , serum_starvation ( 230 ) , serum_withdrawal ( 250 ) , SH-5 ( 238 ) , SH-6 ( 239 , 285 ) , sildenafil ( 15 , 18 ) , silmitasertib ( 120 ) , simvastatin ( 158 ) , SiO2 @AM/CN ( 17 ) , siRNA ( 193 , 197 , 203 , 206 , 209 , 218 , 227 , 232 , 241 , 304 ) , sonolisib ( 57 ) , sorafenib ( 15 , 36 ) , sorbitol ( 235 ) , SP600125 ( 254 , 315 ) , sphingosine_1-phosphate ( 303 , 327 ) , starvation_medium ( 103 ) , staurosporine ( 272 , 333 , 344 ) , STO-609 ( 99 ) , Su11274 ( 69 ) , SU6656 ( 211 ) , tamoxifen ( 174 , 211 ) , tautomycetin ( 166 ) , tautomycin ( 140 ) , TBB ( 264 ) , temsirolimus ( 145 ) , TGF-alpha ( 4 ) , TGF-beta ( 8 ) , thrombin ( 301 , 332 , 356 ) , TNF ( 160 , 203 , 207 , 235 , 280 , 315 ) , Torin1 ( 64 , 111 ) , TPO ( 230 , 356 ) , U0126 ( 64 , 220 , 244 , 298 ) , UCN-01 ( 291 , 333 ) , UV ( 346 ) , V-100 ( 254 ) , valproic_acid ( 22 ) , vanadate ( 213 , 235 , 322 , 341 ) , VEGF ( 47 ) , virus infection ( 207 , 256 , 324 ) , wortmannin ( 158 , 199 , 224 , 257 , 280 , 285 , 296 , 298 , 307 , 311 , 316 , 317 , 321 , 327 , 332 , 335 , 338 , 342 , 347 , 349 , 350 , 353 , 355 , 370 )

Downstream Regulation
Effects of modification on Akt1:
activity, induced ( 281 , 288 , 305 , 323 , 347 , 352 , 369 ) , enzymatic activity, induced ( 50 , 178 , 197 , 201 , 256 , 296 , 301 , 309 , 311 , 316 , 346 , 362 , 367 , 368 , 370 ) , intracellular localization ( 153 , 197 , 216 , 305 , 357 ) , molecular association, regulation ( 8 , 197 , 256 , 369 ) , phosphorylation ( 114 , 353 ) , protein conformation ( 216 )
Effects of modification on biological processes:
apoptosis, altered ( 149 ) , apoptosis, inhibited ( 347 , 355 ) , carcinogenesis, induced ( 177 ) , cell cycle regulation ( 281 ) , cell growth, altered ( 160 , 212 ) , cell growth, induced ( 31 , 58 ) , cell motility, altered ( 197 , 331 ) , cytoskeletal reorganization ( 348 ) , transcription, altered ( 346 )
Induce interaction with:
PAK1 (human) ( 197 ) , PDK1 (human) ( 197 ) , PPP2CA (human) ( 256 ) , TGFBR3 (human) ( 8 ) , TRAF6 (human) ( 8 )

Disease / Diagnostics Relevance
Relevant diseases:
chronic lymphocytic leukemia ( 238 ) , neuroblastoma ( 234 ) , ovarian cancer ( 153 ) , pancreatic cancer ( 42 ) , Kaposi's sarcoma ( 121 ) , melanoma skin cancer ( 177 ) , rhabdomyosarcoma ( 219 ) , diabetes mellitus ( 225 ) , type 2 diabetes ( 139 , 265 )

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Rikova K, Hall B (2013) CST Curation Set: 20738, 21165, 30164, 30165, 30166; Year: 2013; Biosample/Treatment: cell line, H1650, HCC827, H1975, Calu-3, H2106; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
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Rikova K, Hall B (2013) CST Curation Set: 20739, 21166, 30167, 30168, 30169; Year: 2013; Biosample/Treatment: cell line, H2342, H2073, Lou-NH91, HCC15, H1703; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
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Rikova K, Hall B (2013) CST Curation Set: 20740, 21167, 30170, 30171, 30172; Year: 2013; Biosample/Treatment: cell line, H2228, H3122, HCC78, H661, H1781; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
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