Thr308

Site Information
kDGAtMKtFCGtPEy SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 447856
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 120 , 259 , 268 , 298 , 318 , 324 , 345 , 371 ) , flow cytometry ( 290 ) , immunoassay ( 117 , 134 , 139 ) , immunoprecipitation ( 22 , 24 , 36 , 47 , 52 , 58 , 72 , 96 , 99 , 107 , 115 , 118 , 120 , 125 , 137 , 153 , 156 , 169 , 182 , 198 , 357 ) , mass spectrometry ( 10 , 35 , 42 , 72 , 83 , 84 , 85 , 98 , 103 , 109 , 110 , 126 , 127 , 128 , 129 , 165 , 166 , 167 , 170 , 174 , 184 , 185 , 216 ) , mass spectrometry (in vitro) ( 120 ) , microscopy-colocalization with upstream kinase ( 328 ) , mutation of modification site ( 1 , 6 , 7 , 10 , 21 , 36 , 72 , 75 , 81 , 91 , 92 , 120 , 180 , 182 , 197 , 207 , 215 , 218 , 232 , 259 , 270 , 278 , 292 , 298 , 324 , 328 , 333 , 350 , 355 , 360 , 368 , 369 , 371 ) , peptide sequencing ( 33 , 372 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 57 , 58 , 61 , 62 , 63 , 64 , 66 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 82 , 87 , 90 , 93 , 95 , 96 , 97 , 99 , 100 , 102 , 104 , 105 , 106 , 107 , 108 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 161 , 162 , 163 , 164 , 168 , 169 , 171 , 173 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 183 , 186 , 187 , 188 , 189 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 212 , 213 , 214 , 215 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 225 , 226 , 227 , 228 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 250 , 251 , 252 , 253 , 254 , 255 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 320 , 321 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 330 , 331 , 332 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349 , 351 , 352 , 353 , 354 , 355 , 357 , 358 , 359 , 360 , 361 , 362 , 363 , 364 , 366 , 367 , 373 , 374 ) , phosphoamino acid analysis ( 160 , 371 ) , phosphopeptide mapping ( 324 , 371 ) , western blotting ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 37 , 39 , 41 , 42 , 44 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 57 , 58 , 61 , 62 , 63 , 64 , 66 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 82 , 87 , 90 , 92 , 93 , 94 , 95 , 96 , 97 , 99 , 100 , 102 , 104 , 105 , 106 , 107 , 108 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 168 , 169 , 171 , 173 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 186 , 187 , 188 , 189 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 212 , 213 , 214 , 215 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 225 , 226 , 227 , 228 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 252 , 253 , 254 , 255 , 257 , 261 , 267 , 269 , 271 , 273 , 274 , 275 , 277 , 279 , 281 , 282 , 284 , 285 , 287 , 289 , 291 , 295 , 297 , 298 , 300 , 301 , 304 , 305 , 306 , 309 , 310 , 312 , 315 , 317 , 323 , 324 , 326 , 328 , 329 , 330 , 331 , 333 , 334 , 335 , 337 , 340 , 344 , 353 , 354 , 355 , 357 , 358 , 359 , 360 , 361 , 362 , 363 , 364 , 366 , 367 , 372 , 373 , 374 )
Disease tissue studied:	adrenal cancer ( 254 ) , pheochromocytoma ( 254 ) , bone cancer ( 82 , 102 , 137 , 161 , 175 , 189 , 192 , 212 , 219 , 235 , 250 , 279 , 323 ) , Ewing's sarcoma ( 69 , 212 ) , osteosarcoma ( 250 ) , brain cancer ( 42 , 60 , 117 , 131 , 145 , 158 , 175 , 186 , 236 , 241 , 253 , 268 , 359 , 374 ) , astrocytoma ( 268 ) , glioblastoma ( 42 , 60 , 117 , 131 , 145 , 175 , 236 , 241 , 253 , 359 ) , glioblastoma multiforme ( 72 , 131 , 186 ) , glioma ( 42 , 60 , 72 , 117 , 131 , 145 , 175 , 186 , 236 , 241 , 253 , 359 ) , Schwannoma ( 158 , 374 ) , breast cancer ( 3 , 6 , 15 , 22 , 36 , 38 , 50 , 54 , 63 , 72 , 74 , 75 , 90 , 108 , 113 , 115 , 117 , 120 , 136 , 140 , 142 , 144 , 145 , 148 , 161 , 169 , 175 , 176 , 188 , 192 , 196 , 202 , 204 , 207 , 208 , 251 , 269 , 271 , 274 , 305 , 329 ) , breast adenocarcinoma ( 3 , 75 , 90 , 115 , 161 , 192 ) , HER2 positive breast cancer ( 35 ) , luminal A breast cancer ( 35 ) , luminal B breast cancer ( 35 ) , breast cancer, triple negative ( 35 , 63 , 75 , 90 , 115 , 117 , 192 ) , cervical cancer ( 136 , 284 , 300 ) , cervical squamous cell carcinoma ( 300 ) , chondrosarcoma ( 250 ) , colorectal cancer ( 3 , 33 , 38 , 73 , 87 , 112 , 120 , 136 , 137 , 142 , 162 , 171 , 194 , 330 , 335 ) , colorectal carcinoma ( 3 , 33 , 38 , 73 , 87 , 112 , 120 , 136 , 137 , 142 , 162 , 171 , 194 , 330 , 335 ) , endometrial cancer ( 5 , 147 ) , endometrial adenocarcinoma ( 5 , 147 ) , liposarcoma ( 250 ) , gastric cancer ( 34 , 165 , 166 , 275 ) , gastric carcinoma ( 34 , 165 , 166 , 275 ) , gestational cancer ( 143 ) , gestational trophoblastic choriocarcinoma ( 143 ) , kidney cancer ( 92 , 227 , 257 ) , leukemia ( 9 , 26 , 29 , 32 , 62 , 106 , 251 , 361 , 362 ) , acute myelogenous leukemia ( 26 , 29 , 32 , 251 , 361 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 251 , 362 ) , chronic lymphocytic leukemia ( 9 ) , chronic myelogenous leukemia ( 26 ) , T cell leukemia ( 9 , 106 ) , liver cancer ( 48 , 51 , 52 , 58 , 156 , 209 , 239 , 273 ) , liver adenocarcinoma ( 51 ) , hepatocellular carcinoma ( 30 , 48 , 58 , 137 , 156 ) , lung cancer ( 3 , 12 , 17 , 20 , 40 , 83 , 84 , 85 , 111 , 120 , 137 , 140 , 167 , 175 , 194 , 295 , 349 ) , non-small cell lung cancer ( 3 , 12 , 17 , 20 , 23 , 40 , 83 , 85 , 120 , 137 , 167 , 349 ) , non-small cell lung adenocarcinoma ( 3 , 12 , 17 , 20 , 40 , 83 , 84 , 85 , 137 , 167 ) , non-small cell large cell lung carcinoma ( 17 , 20 , 85 ) , non-small cell squamous cell lung carcinoma ( 84 , 167 ) , lymphoma ( 21 , 26 , 68 , 79 , 106 , 123 , 177 , 246 , 251 , 289 , 315 ) , B cell lymphoma ( 7 , 21 , 106 ) , Burkitt's lymphoma ( 289 ) , non-Hodgkin's lymphoma ( 21 , 106 ) , mantle cell lymphoma ( 21 , 106 ) , PEL ( 68 , 123 ) , T cell lymphoma ( 246 ) , malignant fibrous histiocytoma ( 250 ) , neuroblastoma ( 125 , 135 , 198 , 236 , 242 ) , ovarian cancer ( 24 , 37 , 117 , 136 , 142 , 145 , 155 , 158 , 164 , 220 , 305 , 329 ) , ovarian epithelial carcinoma ( 220 ) , pancreatic cancer ( 13 , 23 , 39 , 44 , 96 , 148 , 194 , 277 ) , pancreatic carcinoma ( 13 , 39 , 44 , 96 , 148 , 194 , 277 ) , pancreatic islet cell cancer ( 23 ) , multiple myeloma ( 11 ) , prostate cancer ( 10 , 52 , 79 , 99 , 100 , 105 , 107 , 122 , 136 , 142 , 145 , 152 , 178 , 192 , 193 , 206 , 208 , 244 , 247 , 255 , 335 , 360 , 363 ) , Kaposi's sarcoma ( 123 ) , melanoma skin cancer ( 179 , 207 ) , fibrosarcoma of soft tissue ( 61 , 335 ) , leiomyosarcoma ( 147 , 250 ) , rhabdomyosarcoma ( 212 , 221 , 250 , 309 ) , type 2 diabetes ( 141 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 75 ) , 'brain, hippocampus' ( 163 ) , 'macrophage, alveolar'-lung ( 352 ) , 'muscle, skeletal' ( 76 , 78 , 80 , 138 , 141 , 146 , 205 , 221 , 262 , 263 , 267 , 273 , 285 ) , 'muscle, smooth' ( 285 ) , 'neuron, dorsal root ganglion'-brain ( 291 ) , 'stem, embryonic' ( 104 , 157 ) , 'stem, mesenchymal' ( 14 ) , 1-LN (prostate cell) ( 99 ) , 22Rv1 (prostate cell) ( 206 ) , 293 (epithelial) [IRS1 (human)] ( 225 ) , 293 (epithelial) ( 2 , 47 , 74 , 94 , 96 , 117 , 119 , 121 , 152 , 153 , 159 , 173 , 175 , 183 , 186 , 195 , 201 , 215 , 218 , 232 , 234 , 245 , 254 , 258 , 259 , 260 , 272 , 274 , 282 , 292 , 307 , 312 , 317 , 328 , 331 , 332 , 343 , 346 , 351 , 353 , 366 , 368 , 372 ) , 293E (epithelial) ( 112 , 323 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 298 , 316 , 326 , 339 ) , 3T3 (fibroblast) ( 52 , 120 , 199 , 214 , 218 , 259 , 364 , 369 ) , 661W ( 154 ) , 786-O (renal) ( 92 ) , A2780 (ovarian) ( 136 , 145 , 220 ) , A375 (melanocyte) ( 179 ) , A431 (epithelial) ( 223 , 282 ) , A549 (pulmonary) ( 12 , 17 , 20 , 111 , 137 , 175 , 194 , 276 , 295 ) , A673 (muscle cell) ( 69 ) , adipocyte ( 373 ) , adipocyte-adipose tissue ( 31 ) , adipose tissue ( 46 ) , AGS (gastric) ( 34 ) , AML10 (myeloid) ( 32 ) , AML11 (myeloid) ( 32 ) , AN3-CA (endometrial) ( 147 ) , aorta ( 340 ) , artery-heart ( 248 ) , Aspc1 (pancreatic) ( 44 ) , BAEC (endothelial) ( 201 , 245 , 337 ) , BaF3 ('B lymphocyte, precursor') ( 29 ) , BC3 (B lymphocyte) ( 68 ) , BEAS-2B (epithelial) ( 41 ) , Ben-Men-1 ( 374 ) , BeWo31 ( 187 ) , BeWo ( 187 ) , bile-duct cell-bile-ducts ( 302 ) , Bon1 (pancreatic) ( 23 ) , BPH-1 (epithelial) ( 152 ) , brain ( 236 ) , breast ( 35 ) , breast cell-breast ( 294 ) , BT-20 (breast cell) ( 117 ) , BT-474 (breast cell) ( 3 , 38 , 90 , 136 , 140 , 148 , 271 , 283 ) , BT-549 (breast cell) ( 63 , 90 ) , BTIC-12 (glial) ( 60 ) , BTIC-48 (glial) ( 60 ) , BxPC-3 (pancreatic) ( 148 ) , C2C12 (myoblast) [SPRY2 (human), transfection] ( 261 ) , C2C12 (myoblast) ( 261 , 285 , 309 ) , C33-A (cervical) ( 136 , 284 ) , C4-2 (prostate cell) ( 178 ) , Calu-1 (squamous) ( 137 ) , Calu-3 (pulmonary) ( 83 ) , Capan1 (pancreatic) ( 39 ) , CCLP1 (hepatic) ( 302 ) , CD18/HPAF (pancreatic) ( 39 ) , CH27 (squamous) ( 339 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 316 ) , CHO (fibroblast) [EPOR (human)] ( 232 ) , CHO (fibroblast) [INSR (human), transfection] ( 355 ) , CHO (fibroblast) ( 27 , 259 , 287 , 368 ) , CHO-K1 (fibroblast) ( 75 ) , COS (fibroblast) ( 199 , 202 , 291 , 298 , 324 , 335 , 343 , 347 , 351 , 357 , 367 , 371 ) , COS7 (fibroblast) ( 146 , 217 ) , CTL-EN (T lymphocyte) ( 304 ) , CWR22Rv1 (prostate cell) ( 105 ) , DF1 (fibroblast) ( 235 ) , DLBCL (B lymphocyte) ( 7 ) , DLD1 (intestinal) ( 137 , 171 , 265 ) , DM4 (melanocyte) ( 179 ) , DU 145 (prostate cell) ( 99 , 223 , 363 ) , EA.hy 926 (endothelial) ( 342 ) , embryo ( 235 ) , endothelial-vein ( 350 ) , epithelial-lens ( 150 ) , erythroblast ( 361 ) , ES (stem) ( 254 ) , fibroblast-embryo ( 94 , 180 ) , fibroblast-foreskin ( 72 ) , FL5.12 (lymphoid) ( 214 ) , GI-101A (breast cell) ( 305 , 329 ) , glial-brain ( 42 ) , GM00637 (lymphoblast) ( 278 ) , GM08391 (fibroblast) ( 278 ) , GM09607 (fibroblast) ( 278 ) , GRANTA-519 (B lymphocyte) ( 21 ) , H2009 (pulmonary) ( 64 ) , HaCaT (keratinocyte) ( 28 , 160 , 314 , 348 ) , HAEC (endothelial) ( 210 , 340 ) , HAK-1A (hepatic) ( 30 ) , HAK-1B (hepatic) ( 30 ) , HBL-100 (breast cell) ( 90 ) , HCC (hepatic) ( 137 ) , HCC1428 (breast cell) ( 15 ) , HCC15 (pulmonary) ( 84 ) , HCC1500 (breast cell) ( 15 ) , HCC44 (pulmonary) ( 137 ) , HCC78 (pulmonary) ( 85 ) , HCC827 (pulmonary) ( 83 ) , HCCLM3 (hepatic) ( 48 ) , HCN-2 ('neuron, cortical') ( 181 ) , HCT116 (intestinal) ( 3 , 33 , 38 , 87 , 120 , 136 , 137 , 171 , 194 , 265 ) , HCT15 (intestinal) ( 73 ) , heart ( 146 , 161 ) , HEC-50B (endometrial) ( 147 ) , HEI-193 (Schwann) ( 158 , 374 ) , HEK293T (epithelial) ( 25 , 36 , 56 , 81 , 114 , 124 , 137 , 146 , 182 , 197 , 228 , 270 , 271 , 276 , 335 , 336 ) , HeLa (cervical) ( 1 , 19 , 52 , 70 , 72 , 75 , 102 , 118 , 120 , 121 , 132 , 133 , 134 , 146 , 168 , 184 , 185 , 219 , 223 , 230 , 232 , 243 , 276 , 282 , 299 , 306 ) , hematopoietic progenitor-bone marrow ( 238 ) , Hep 3B2.1-7 (hepatic) ( 302 ) , hepatocyte ( 94 ) , hepatocyte-liver ( 6 , 97 , 301 ) , HepG2 (hepatic) ( 52 , 209 , 239 , 263 , 273 ) , HEY (ovarian) ( 305 , 329 ) , HGC-27 (gastric) ( 34 ) , HL60 (myeloid) ( 26 , 62 , 311 , 318 , 345 ) , HLMVECs ( 71 ) , HPB-ALL (T lymphocyte) ( 315 ) , HS294T (melanocyte) ( 179 ) , HT-29 (intestinal) ( 112 , 142 , 270 , 276 , 313 , 330 ) , HT1080 (fibroblast) ( 61 , 292 , 335 ) , hTERT-RPE1 (epithelial) ( 102 ) , HuCCT1 (hepatic) ( 302 ) , HUES-1 ('stem, embryonic') ( 18 ) , HUES-7 ('stem, embryonic') ( 18 ) , HUES-9 ('stem, embryonic') ( 18 ) , Huh7 (hepatic) ( 156 , 209 ) , HUT-78 (T lymphocyte) ( 246 ) , HUVEC (endothelial) ( 49 , 148 , 195 , 287 , 296 , 320 , 333 , 345 , 347 ) , IGROV1 (ovarian) ( 164 ) , IMR32 (neural crest) ( 236 ) , Ishikawa (endometrial) ( 147 ) , JB (epithelial) ( 297 ) , JEG-3 (uterine) ( 143 ) , JEKO-1 (B lymphocyte) ( 21 , 106 ) , Jurkat (T lymphocyte) ( 9 , 103 , 106 , 126 , 127 , 128 , 129 , 170 , 174 , 216 , 246 , 266 , 288 , 290 , 315 , 339 ) , K562 (erythroid) ( 26 ) , KB (squamous) ( 300 ) , KELLY (neural crest) ( 236 ) , keratinocyte ( 6 ) , KG-1 (myeloid) ( 251 ) , kidney [KLK1 (human)] ( 227 ) , KLE (endometrial) ( 5 , 147 ) , KM20 ( 112 ) , KPL-1 (breast cell) ( 136 ) , L3.6p1 (pancreatic) ( 39 ) , L6 (myoblast) ( 80 , 225 , 262 , 368 , 372 ) , LAN-1 (neural crest) ( 198 ) , leukocyte-blood ( 81 ) , liver ( 8 , 146 , 273 ) , LN-Z308 (glial) ( 241 ) , LN229 (glial) ( 131 ) , LNCaP (prostate cell) ( 100 , 145 , 192 , 206 , 244 , 247 , 360 , 363 ) , LOU-NH91 (squamous) ( 84 ) , LS-513 (intestinal) ( 136 ) , lung ( 83 , 84 , 85 , 161 ) , mammary gland ( 338 ) , MCF-10A (breast cell) [GAB2 (human), transfection] ( 202 ) , MCF-10A (breast cell) ( 74 , 142 , 204 , 329 ) , MCF-7 (breast cell) [CYP19A1 (human)] ( 269 ) , MCF-7 (breast cell) ( 3 , 15 , 22 , 72 , 74 , 90 , 108 , 136 , 169 , 175 , 192 , 196 , 207 , 208 , 223 , 251 , 274 ) , MDA-MB-231 (breast cell) ( 3 , 6 , 36 , 50 , 54 , 90 , 115 , 120 , 136 , 142 , 144 , 145 , 176 , 188 , 196 , 208 ) , MDA-MB-361 (breast cell) ( 3 , 90 , 161 ) , MDA-MB-435 (breast cell) ( 90 , 113 ) , MDA-MB-453 (breast cell) ( 90 ) , MDA-MB-468 (breast cell) ( 75 , 90 , 115 , 192 ) , MEF (fibroblast) ( 47 , 52 , 72 , 112 , 120 , 133 , 137 , 146 , 173 , 182 ) , MEF (fibroblast) [Etk (human), heterozygous knockout] ( 93 ) , MEF (fibroblast) [HRas (human)] ( 252 ) , MEF (fibroblast) [IGF1R (mouse)] ( 305 ) , MEF (fibroblast) [p70S6K (mouse), homozygous knockout] ( 157 ) , MEF (fibroblast) [TSC22D2 (human)] ( 223 ) , MEL624 (melanocyte) ( 179 ) , mesangial ( 281 ) , MeWo (melanocyte) ( 179 ) , MHCC97-L (hepatic) ( 48 ) , MIA PaCa (pancreatic) ( 223 ) , MIA PaCa-2 (pancreatic) ( 194 ) , MKN-45 (gastric) ( 165 , 166 , 275 ) , MOLT-4 (T lymphocyte) ( 246 ) , monocyte-blood ( 130 ) , mononuclear ( 240 ) , mononuclear-blood ( 9 ) , MSN (neuron) ( 293 ) , muscle ( 264 ) , MV4-11 (macrophage) ( 29 , 32 ) , N1 ( 4 ) , NB-4 (myeloid) ( 251 ) , NCI-H1299 (pulmonary) ( 120 ) , NCI-H157 (pulmonary) ( 120 , 270 ) , NCI-H1650 (pulmonary) ( 83 ) , NCI-H1703 (squamous) ( 84 , 167 ) , NCI-H1781 (pulmonary) ( 85 ) , NCI-H1975 (pulmonary) ( 3 , 17 , 20 , 40 , 83 ) , NCI-H1993 (pulmonary) ( 137 ) , NCI-H2073 (pulmonary) ( 84 , 137 ) , NCI-H2106 (pulmonary) ( 83 ) , NCI-H2228 (pulmonary) ( 85 ) , NCI-H2342 (pulmonary) ( 84 ) , NCI-H292 (pulmonary) ( 140 ) , NCI-H3122 (pulmonary) ( 85 ) , NCI-H3255 (pulmonary) ( 98 ) , NCI-H345 (pulmonary) ( 286 ) , NCI-H358 (pulmonary) ( 137 ) , NCI-H441 (pulmonary) ( 137 ) , NCI-H460 (pulmonary) ( 17 , 20 , 223 ) , NCI-H510 (pulmonary) ( 286 ) , NCI-H661 (pulmonary) ( 85 ) , NCI-H69 (pulmonary) ( 286 ) , NCI-H727 (epithelial) ( 23 ) , neuron-'brain, hippocampus' ( 163 ) , neutrophil ( 226 , 310 , 344 , 345 , 353 ) , NL-17 (intestinal) ( 335 ) , NSCLC (pulmonary) ( 349 ) , OAW28 (ovarian) ( 24 ) , OCI-ly7 (B lymphocyte) ( 55 ) , OCI/AML3 (myeloid) ( 32 ) , OK (renal) ( 222 ) , oocyte ( 91 , 116 ) , ovary ( 155 ) , OVCAR3 (ovarian) ( 24 , 164 ) , OVCAR5 (ovarian) ( 164 ) , PAE (endothelial) ( 47 , 347 ) , PANC-1 (pancreatic) ( 44 , 194 ) , pancreas ( 44 , 277 ) , PC-12 (chromaffin) ( 254 ) , PC3 (prostate cell) ( 10 , 52 , 79 , 99 , 107 , 122 , 136 , 142 , 145 , 178 , 193 , 208 , 223 , 255 , 276 , 335 , 363 ) , platelet-blood ( 233 , 303 , 334 , 358 ) , pp126 (keratinocyte) ( 325 ) , QGP-1 (endocrine) ( 23 ) , RAMOS (B lymphocyte) ( 289 ) , Rh1 (bone cell) ( 212 ) , Rh13 (muscle cell) ( 309 ) , Rh18 (muscle cell) ( 212 , 309 ) , Rh30 ('muscle, skeletal') ( 212 , 221 , 309 ) , Rh4 (muscle cell) ( 309 ) , Rh41 ( 212 ) , Rh5 (muscle cell) ( 309 ) , RPMI-8266 (plasma cell) ( 11 ) , RWP1 (pancreatic) ( 96 ) , Saos-2 (bone cell) ( 258 ) , SB2 (melanocyte) ( 179 ) , SCC12 (keratinocyte) ( 341 ) , Schwann ( 197 ) , SG231 (hepatic) ( 302 ) , SH-SY5Y (neural crest) ( 125 , 135 , 236 , 242 , 307 , 308 ) , SHEP (neuron) ( 236 , 293 ) , SK-HEP-1 (endothelial) ( 51 ) , SK-LU-1 (pulmonary) ( 137 ) , SK-MEL2 (melanocyte) ( 179 ) , SK-MEL28 (melanocyte) ( 45 ) , SK-MEL5 (melanocyte) ( 179 ) , SK-N-BE(2) (neural crest) ( 236 ) , SK-N-MC (neural crest) ( 293 ) , SKBr3 (breast cell) ( 90 , 140 , 283 ) , SKBR7 (breast cell) ( 36 ) , skin ( 28 , 179 ) , SKNSH (neural crest) ( 236 ) , SKOV-3 (ovarian) ( 37 , 117 , 142 , 158 , 164 , 324 ) , SKRC-44 (renal) ( 257 ) , SKUT-1 ( 147 ) , SMMC7721 (hepatocyte) ( 51 ) , SRB-1 (squamous) ( 314 ) , SU-DHL-2 (B lymphocyte) ( 55 ) , Su.86.86 (pancreatic) ( 13 , 44 ) , SUM149 (breast cell) ( 38 ) , SW1463 (intestinal) ( 136 ) , SW48 (intestinal) ( 73 ) , SW620 (intestinal) ( 73 ) , T lymphocyte-blood ( 231 ) , T47D (breast cell) ( 15 , 22 , 72 , 90 , 136 , 305 ) , T84 (intestinal) ( 162 ) , T98G (glial) ( 72 , 131 ) , TF-1 (erythroid) ( 251 , 362 ) , THP1 (myeloid) ( 26 , 354 ) , U-251 MG (glial) ( 241 , 253 ) , U-937 (myeloid) ( 26 , 79 , 177 , 251 , 315 ) , U2OS (bone cell) [GR (human)] ( 323 ) , U2OS (bone cell) ( 82 , 102 , 137 , 161 , 175 , 189 , 192 , 219 , 235 , 279 ) , U373 MG (glial) ( 186 ) , U87MG (glial) ( 117 , 145 , 175 , 236 , 253 , 268 , 359 ) , UACC-257 (melanocyte) ( 179 ) , UCSD-354L (melanocyte) ( 179 ) , UT-7 (myeloid) [EPO (human), transfection] ( 361 ) , VSMC-aorta ( 151 ) , WI-38 (fibroblast) ( 192 ) , WiDr (epithelial) ( 33 ) , WM-1552 (melanocyte) ( 179 ) , WM1799 (melanocyte) ( 179 ) , WM2664 (melanocyte) ( 179 ) , WM3211 (melanocyte) ( 179 ) , WM35 (melanocyte) ( 179 , 207 ) , WM46 (melanocyte) ( 179 ) , WM793 ( 142 ) , ZR-75-1 (breast cell) ( 90 )

Upstream Regulation
Regulatory protein:	Ack (human) ( 48 ) , ADRA1B (human) ( 322 ) , Akt1 (human) ( 108 , 116 , 142 , 183 , 199 , 213 , 331 , 359 ) , Akt2 (human) ( 183 , 199 ) , AMIGO2 (human) ( 49 ) , AMPKA1 (human) ( 3 ) , APPL (mouse) ( 97 ) , BAP28 (human) ( 44 ) , Bcr (human) ( 7 ) , beclin 1 (human) ( 50 ) , BRAF (human) ( 179 ) , Brk (human) ( 107 , 152 ) , CA9 (human) ( 257 ) , CAMKK1 (human) ( 331 ) , CAMKK2 (human) ( 3 ) , CD133 (human) ( 56 ) , CDK1 (human) ( 18 ) , CHKA (human) ( 196 ) , CHKB (human) ( 196 ) , CIP2A (human) ( 74 ) , CSF2RB (human) ( 304 ) , CYP3A5 (human) ( 58 ) , DDIT4 (human) ( 2 , 272 ) , DDIT4L (human) ( 272 ) , DYRK2 (human) ( 22 ) , Epac1 (human) ( 99 ) , ERK1 (human) ( 232 ) , ERK2 (human) ( 232 ) , Etk (human) ( 93 ) , FKBP5 (human) ( 5 ) , FRK (human) ( 189 ) , GAB2 (human) ( 202 ) , GRB2 (human) ( 151 ) , GRP78 (human) ( 143 ) , GSK3A (human) ( 115 ) , HER2 (human) ( 90 ) , HER3 (human) ( 164 ) , HRas (human) ( 142 , 280 , 322 , 364 ) , HSP90A (human) ( 215 ) , IEX-1 (human) ( 232 ) , IKKB (human) ( 205 ) , IKKE (human) ( 120 ) , IL24 (human) ( 53 ) , IL2RA (human) ( 231 ) , ILK (human) ( 208 , 253 , 306 , 312 , 363 ) , INPP4B (human) ( 33 ) , INPP5E (human) ( 336 ) , IRAK4 (human) ( 95 ) , IRS2 (human) ( 94 ) , KLK1 (human) ( 227 ) , KRas (human) ( 137 , 280 ) , LIMS1 (human) ( 306 ) , LKB1 (human) ( 230 ) , LYN (human) ( 211 ) , MEK1 (human) ( 329 ) , Met (human) ( 71 ) , MINK (human) ( 36 ) , MST2 (human) ( 158 ) , mTOR (human) ( 116 , 183 , 210 ) , MYO6 (human) ( 12 ) , NRas (human) ( 179 ) , OSBPL9 (human) ( 234 ) , P130Cas (human) ( 89 ) , p300 (human) ( 146 ) , p53 (human) ( 192 ) , PAK1 (human) ( 243 ) , PAK1 (rat) ( 199 ) , PAK2 (human) ( 199 , 243 ) , PCAF (human) ( 146 ) , PCTP (human) ( 94 ) , PDK1 (human) ( 120 , 137 , 173 , 215 , 328 ) , PDK1 (mouse) ( 285 , 355 ) , PHLDA3 (human) ( 192 ) , PHLPP (human) ( 112 , 142 , 229 ) , PHLPP2 (human) ( 112 , 142 , 229 ) , PIK3CA (human) ( 142 , 204 , 240 ) , PIK3CG (human) ( 291 ) , PIK3R1 (human) ( 10 , 120 ) , PIK3R2 (human) ( 71 ) , PINK1 (human) ( 135 ) , PKACA (mouse) ( 97 ) , PKCB (human) ( 240 ) , PKCT (mouse) ( 92 ) , PKN1 (human) ( 355 ) , PKN2 (human) ( 355 , 357 ) , PLD2 (human) ( 217 ) , PPP1CA (human) ( 150 ) , PPP1R2 (human) ( 242 ) , PPP2CA (human) ( 112 , 168 , 214 ) , PPP2R2A (human) ( 26 , 39 , 41 ) , PPP2R5B (human) ( 232 ) , PRICKLE1 (human) ( 36 ) , PTEN (human) ( 63 , 136 , 235 , 359 , 363 , 364 ) , PTPRJ (human) ( 195 ) , PTPRK (human) ( 56 ) , PXN iso2 (human) ( 171 ) , RAC1 (human) ( 199 ) , Raptor (human) ( 74 , 183 ) , RHEBL1 (human) ( 16 ) , RICTOR (human) ( 137 , 183 , 193 ) , RMP (human) ( 219 ) , RRas (human) ( 142 ) , SHIP (human) ( 288 ) , SHIP-2 (human) ( 142 ) , SHIP-2 (mouse) ( 359 ) , SHP-1 (human) ( 119 ) , SHPS1 (human) ( 151 ) , Sin1 (human) ( 137 ) , SIRT1 (human) ( 75 , 146 ) , SIRT2 (human) ( 75 ) , SKP2 (human) ( 3 ) , SPRY2 (human) ( 261 ) , Src (human) ( 213 , 322 ) , ST3GAL5 (human) ( 62 ) , ST8SIA1 (human) ( 62 ) , TACC3 (human) ( 51 ) , THEM2 (human) ( 94 ) , TIMP1 (human) ( 64 ) , TRAF6 (human) ( 182 ) , ULK1 (human) ( 228 ) , USP49 (human) ( 13 ) , ZFP57 (human) ( 61 )
Putative in vivo kinases:	AXL (human) ( 27 ) , IKKE (human) ( 120 ) , Mer (human) ( 27 ) , PDK1 (human) ( 52 , 136 , 151 , 330 , 335 ) , PIK3CA (human) ( 94 ) , PRKD1 (human) ( 328 ) , TBK1 (human) ( 137 ) , Tyro3 (human) ( 27 )
Kinases, in vitro:	IKKE (human) ( 120 ) , PDK1 (human) ( 256 , 276 , 335 , 365 , 370 ) , PKCA (human) ( 358 ) , PKCB (human) ( 358 ) , TBK1 (human) ( 137 )
Putative upstream phosphatases:	PPP2CA (human) ( 44 , 188 ) , PTEN (human) ( 24 )
Phosphatases, in vitro:	PPP2CA (human) ( 214 ) , PTEN (human) ( 24 )
Treatments:	1-methyladenine ( 116 ) , 2-deoxyglucose ( 300 ) , 4-DAMP ( 100 ) , 4-HT ( 176 , 213 , 328 ) , 5-cholesten-5-beta-ol ( 160 ) , 8-CPT-2Me-cAMP ( 99 ) , 8-Rp-cAMP ( 248 ) , 9cRA ( 176 ) , A-443654 ( 156 ) , actinomycin_D ( 157 ) , activin ( 104 ) , ADA ( 226 ) , adiponectin ( 188 , 230 ) , adriamycin ( 182 ) , afatinib ( 40 ) , AG1024 ( 305 ) , AG1296 ( 305 ) , AG1478 ( 135 , 160 , 282 , 305 ) , AGK2 ( 75 ) , Akt-I-1 ( 168 , 222 , 284 ) , Akt-I-1,2 ( 284 ) , Akt_inhibitor_VIII ( 135 , 153 ) , alpelisib ( 23 ) , alpha-mangostin ( 144 ) , amino_acids ( 262 , 323 ) , androstanolone ( 105 ) , angiotensin ( 296 ) , anti-Akt1 ( 271 ) , anti-CD3/CD28 ( 231 ) , anti-E-cadherin ( 325 ) , anti-HER2 ( 283 ) , anti-HLA ( 210 ) , anti-ICAM-2 ( 339 ) , anti-IgM ( 21 , 240 ) , anti-integrin_alpha9beta1 ( 142 ) , anti-PDGFR ( 305 ) , apelin ( 287 ) , API-2 ( 120 ) , arachidonic_acid ( 345 ) , atiprimod ( 239 ) , AZD8055 ( 175 ) , BAPTA-AM ( 255 , 303 , 358 ) , BAR501 ( 65 ) , BCI-121 ( 25 ) , BDNF ( 60 ) , bisindolylmaleimide ( 240 , 358 ) , BQ-123 ( 282 ) , BQ-788 ( 282 ) , bradykinin ( 347 ) , bumetanide ( 237 ) , C2-ceramide ( 355 ) , C6-ceramide ( 37 , 362 ) , caffeine ( 297 ) , calyculin_A ( 142 , 233 , 237 , 248 , 255 , 362 ) , cAMP_analog ( 197 ) , cangrelor ( 303 ) , carbachol ( 100 ) , CAY10399 ( 226 ) , CCCP ( 307 ) , celastrol ( 79 ) , celecoxib ( 302 , 330 ) , cell_adhesion ( 177 ) , CGS_21680 ( 226 ) , cholesterol ( 160 ) , cholesterol_oxidase ( 160 ) , ciclosporin ( 131 , 255 ) , cisplatin ( 182 ) , colforsin ( 197 , 226 , 248 , 351 ) , collagen ( 334 ) , collagen XIX (NC1 domain) ( 45 ) , compound_7 ( 136 ) , compound_C ( 3 ) , conditioned medium ( 32 ) , convulxin ( 334 ) , CTGF ( 281 ) , culturing_of_cells ( 163 , 240 ) , CXCL12 ( 240 , 243 ) , cyclic_stretch ( 282 ) , cycloheximide ( 118 ) , dactolisib ( 106 , 204 ) , dasatinib ( 142 ) , decorin ( 342 ) , deoxygenation ( 77 ) , depolarization ( 242 ) , derivative-2 ( 68 ) , dexamethasone ( 176 ) , DMSO ( 204 , 213 ) , doxycycline ( 2 ) , dronabinol ( 246 ) , duvelisib ( 32 ) , EF24 ( 220 ) , EGF ( 3 , 6 , 12 , 37 , 75 , 112 , 115 , 135 , 137 , 152 , 158 , 202 , 229 , 244 , 247 , 257 , 285 , 297 , 305 , 313 , 351 ) , EGTA ( 100 ) , englerin_A ( 92 ) , ephrin_A1 ( 142 , 186 ) , Epo ( 232 , 361 ) , erbstatin ( 340 ) , erlotinib ( 57 ) , estrogen_deprivation ( 269 ) , ethanol ( 142 , 325 ) , exercise ( 78 ) , exercise training ( 141 ) , fasting ( 76 , 78 ) , FGF2 ( 104 , 261 ) , fibronectin ( 87 ) , Filipin ( 160 ) , fingolimod ( 26 , 29 , 315 ) , FL ( 29 ) , fluid_shear_stress ( 337 ) , FMK-MEA ( 73 ) , fMLP ( 226 , 344 , 345 ) , FTI277 ( 280 ) , ganglioside ( 341 ) , gefitinib ( 57 , 98 ) , genistein ( 340 ) , GF109203X ( 287 , 303 ) , GH ( 76 ) , ghrelin ( 119 ) , glabridin ( 111 ) , glucose ( 137 , 203 ) , glucose_starvation ( 3 , 225 ) , GM-CSF ( 362 ) , Go_6976 ( 358 ) , growth_factor_withdrawal ( 154 ) , GSK2334470 ( 11 , 15 , 52 ) , GSK690693 ( 120 ) , H-89 ( 226 , 322 ) , H2O2 ( 3 , 153 , 154 , 173 , 201 , 237 ) , heat_shock ( 298 , 307 ) , hepatitis C virus expression ( 8 ) , heregulin ( 104 ) , HGF ( 34 , 58 , 71 , 87 , 301 ) , high-fat diet ( 119 , 373 ) , HNMPA(AM)3 ( 181 ) , HU-210 ( 319 ) , hypotonic_buffer ( 237 ) , hypoxia ( 3 , 187 ) , hypoxia/reoxygenation ( 256 ) , ibrutinib ( 9 , 55 ) , IC87114 ( 226 ) , ICAM-2 ( 339 ) , idelalisib ( 21 ) , IFN-gamma ( 162 ) , IGF-1 ( 3 , 50 , 104 , 105 , 149 , 151 , 169 , 182 , 212 , 218 , 237 , 260 , 274 , 305 , 306 , 307 , 324 , 349 , 372 ) , IGF-2 ( 61 , 309 ) , IgG ( 325 ) , IL-13 ( 330 ) , IL-1a ( 95 ) , IL-1b ( 182 , 331 ) , IL-3 ( 214 ) , IL-6 ( 263 ) , imatinib ( 142 ) , insulin ( 31 , 75 , 80 , 94 , 97 , 112 , 118 , 120 , 124 , 137 , 138 , 141 , 153 , 156 , 168 , 183 , 191 , 209 , 223 , 225 , 228 , 230 , 261 , 262 , 263 , 264 , 270 , 273 , 278 , 285 , 296 , 300 , 307 , 316 , 317 , 321 , 323 , 326 , 332 , 340 , 343 , 346 , 355 , 372 , 373 ) , ionomycin ( 100 , 331 ) , IP(6) ( 178 ) , IQA ( 266 ) , isoproterenol ( 322 ) , isosilybin_B ( 206 ) , K252a ( 281 ) , KCl ( 237 ) , KHS101 ( 51 ) , KN-93 ( 100 ) , KP-372-1 ( 251 ) , KP-392 ( 363 ) , KU-0063794 ( 79 ) , LAM ( 354 ) , laminin-1 ( 87 ) , leptin ( 340 ) , linoleic_acid ( 80 ) , losartan ( 282 , 296 ) , low_glucose ( 146 ) , LPA ( 305 , 329 ) , LPS ( 46 , 130 , 137 , 182 , 352 ) , LY294002 ( 2 , 71 , 75 , 95 , 102 , 104 , 118 , 120 , 137 , 142 , 160 , 168 , 169 , 196 , 203 , 217 , 218 , 223 , 232 , 238 , 240 , 244 , 246 , 247 , 248 , 259 , 266 , 270 , 282 , 299 , 301 , 303 , 311 , 318 , 319 , 322 , 325 , 328 , 329 , 334 , 340 , 348 , 349 , 352 , 355 , 356 , 358 , 359 , 362 ) , LY333531 ( 240 ) , major_basic_protein ( 310 ) , mastoparan ( 319 ) , meal feeding ( 78 ) , methyl-beta-cyclodextrin ( 160 ) , MG132 ( 245 ) , MK-2206 ( 26 , 60 , 102 , 120 ) , Mn(2+) ( 142 ) , N6-benzoyl-cAMP ( 99 ) , NAC ( 154 ) , naltrindole ( 286 ) , neuregulin ( 164 , 197 ) , neurotrophin-3 ( 60 ) , NGF ( 254 , 308 ) , nicotinamide ( 75 , 146 ) , nicotine ( 295 ) , NS398 ( 275 ) , okadaic_acid ( 44 , 116 , 118 , 121 , 142 , 154 , 168 , 177 , 188 , 245 , 255 , 270 , 315 , 362 ) , oleic_acid ( 80 ) , OSI-027 ( 106 ) , OSU-03012 ( 42 , 221 ) , OSU-T315 ( 374 ) , ouabain ( 222 ) , PAR1-activating_peptide ( 303 ) , PAR4-activating_peptide ( 303 ) , PD0325901 ( 73 ) , PD168393 ( 282 ) , PD98059 ( 142 , 259 , 318 , 329 , 344 ) , PDGF ( 3 , 171 , 199 , 218 , 297 , 298 , 305 , 336 , 369 ) , PDK1_inhibitor_3 ( 145 ) , pemetrexed ( 17 , 20 , 38 ) , perifosine ( 120 ) , PF-04691502 ( 117 ) , PGE2 ( 226 ) , phorbol_ester ( 66 , 237 , 238 , 240 , 303 , 317 , 323 , 346 , 358 ) , PI-103 ( 135 , 204 ) , pictilisib ( 94 ) , PIK-93 ( 204 ) , PIK90 ( 204 ) , pimenta doica ( 54 ) , PKC_inhibitor_myristoylated ( 287 ) , PKI-402 ( 161 ) , PLS-123 ( 55 ) , PLTP ( 181 ) , PP-110 ( 204 ) , PP1 ( 259 ) , PP2 ( 142 , 195 , 322 ) , PP242 ( 11 , 73 , 149 , 157 , 191 ) , PP30 ( 191 ) , PTP1B_inhibitor ( 124 ) , PTX ( 282 , 287 , 329 ) , PUGNAc ( 108 ) , QLT0254 ( 277 ) , racepinefrine ( 100 , 138 ) , rapamycin ( 30 , 73 , 94 , 106 , 112 , 130 , 142 , 149 , 157 , 175 , 207 , 212 , 230 , 259 , 287 , 300 , 323 , 356 ) , resveratrol ( 146 , 153 ) , retinoic_acid ( 157 , 176 ) , rimonabant ( 319 ) , Ro31-8220 ( 238 ) , salicylate ( 317 , 356 ) , sardomozide ( 198 ) , SB203580 ( 329 , 353 ) , SCF ( 238 ) , scratch wound ( 77 ) , selenite ( 255 ) , serum ( 4 , 102 , 182 , 186 , 199 , 204 , 214 , 223 , 241 , 247 , 258 , 297 , 349 , 363 ) , serum_starvation ( 134 , 232 ) , serum_withdrawal ( 252 ) , SH-5 ( 240 ) , SH-6 ( 241 , 287 ) , sildenafil ( 17 , 20 ) , silmitasertib ( 122 , 148 ) , simvastatin ( 160 ) , SiO2 @AM/CN ( 19 ) , siRNA ( 120 , 137 , 195 , 199 , 205 , 208 , 211 , 220 , 229 , 234 , 243 , 306 ) , sonolisib ( 59 ) , sorafenib ( 17 , 38 ) , sorbitol ( 237 ) , SP600125 ( 79 , 256 , 317 ) , sphingosine_1-phosphate ( 305 , 329 ) , sphingosylphosphorylcholine ( 16 ) , starvation_medium ( 104 ) , staurosporine ( 79 , 274 , 335 , 346 ) , STO-609 ( 3 , 100 ) , Su11274 ( 71 ) , SU6656 ( 213 ) , tamoxifen ( 176 , 213 ) , tautomycetin ( 168 ) , tautomycin ( 142 ) , TBB ( 266 ) , temsirolimus ( 147 ) , TGF-alpha ( 6 ) , TGF-beta ( 10 ) , thapsigargin ( 97 ) , thrombin ( 303 , 334 , 358 ) , TNF ( 162 , 205 , 209 , 237 , 282 , 317 ) , Torin1 ( 66 , 113 , 114 ) , TPO ( 232 , 358 ) , tunicamycin ( 143 ) , U0126 ( 66 , 222 , 246 , 300 ) , UCN-01 ( 156 , 293 , 335 ) , UV ( 348 ) , V-100 ( 256 ) , valproic_acid ( 24 ) , vanadate ( 215 , 237 , 324 , 343 ) , VEGF ( 49 ) , virus infection ( 137 , 209 , 258 , 326 ) , wortmannin ( 79 , 94 , 120 , 135 , 160 , 201 , 226 , 259 , 282 , 287 , 298 , 300 , 309 , 313 , 318 , 319 , 323 , 329 , 334 , 337 , 340 , 344 , 349 , 351 , 352 , 355 , 357 , 372 )

Downstream Regulation
Effects of modification on Akt1:	activity, induced ( 91 , 283 , 290 , 307 , 325 , 349 , 354 , 371 ) , enzymatic activity, induced ( 52 , 75 , 94 , 120 , 134 , 180 , 199 , 203 , 258 , 298 , 303 , 311 , 313 , 318 , 348 , 364 , 369 , 370 , 372 ) , intracellular localization ( 155 , 161 , 199 , 218 , 307 , 359 ) , molecular association, regulation ( 10 , 199 , 258 , 371 ) , phosphorylation ( 116 , 137 , 146 , 355 ) , protein conformation ( 218 )
Effects of modification on biological processes:	apoptosis, altered ( 151 ) , apoptosis, inhibited ( 117 , 137 , 148 , 349 , 357 ) , carcinogenesis, induced ( 3 , 120 , 137 , 148 , 179 ) , cell cycle regulation ( 148 , 283 ) , cell growth, altered ( 162 , 214 ) , cell growth, induced ( 33 , 60 , 95 , 117 , 148 ) , cell growth, inhibited ( 161 ) , cell motility, altered ( 199 , 333 ) , cell motility, induced ( 3 , 71 , 148 ) , cytoskeletal reorganization ( 350 ) , signaling pathway regulation ( 71 , 80 , 117 , 137 , 148 , 368 ) , transcription, altered ( 348 ) , transcription, induced ( 81 )
Induce interaction with:	PAK1 (human) ( 199 ) , PDK1 (human) ( 199 ) , PPP2CA (human) ( 258 ) , TGFBR3 (human) ( 10 ) , TRAF6 (human) ( 10 )

Disease / Diagnostics Relevance
Relevant diseases:	HNSCC ( 139 ) , chronic lymphocytic leukemia ( 240 ) , neuroblastoma ( 236 ) , ovarian cancer ( 155 ) , pancreatic cancer ( 44 ) , Kaposi's sarcoma ( 123 ) , melanoma skin cancer ( 179 ) , rhabdomyosarcoma ( 221 ) , diabetes mellitus ( 227 ) , type 2 diabetes ( 141 , 267 )

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83	Rikova K, Hall B (2013) CST Curation Set: 20738, 21165, 30164, 30165, 30166; Year: 2013; Biosample/Treatment: cell line, H1650, HCC827, H1975, Calu-3, H2106; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P Curated Info
84	Rikova K, Hall B (2013) CST Curation Set: 20739, 21166, 30167, 30168, 30169; Year: 2013; Biosample/Treatment: cell line, H2342, H2073, Lou-NH91, HCC15, H1703; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P Curated Info
85	Rikova K, Hall B (2013) CST Curation Set: 20740, 21167, 30170, 30171, 30172; Year: 2013; Biosample/Treatment: cell line, H2228, H3122, HCC78, H661, H1781; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P Curated Info
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103	Mulhern D (2012) CST Curation Set: 13939; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Curated Info
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110	Rikova K (2011) CST Curation Set: 13131; Year: 2011; Biosample/Treatment: cell line, MGH-9/unknown; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
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126	Guo A (2011) CST Curation Set: 11885; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Curated Info
127	Guo A (2011) CST Curation Set: 11890; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Curated Info
128	Guo A (2011) CST Curation Set: 11891; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Curated Info
129	Guo A (2011) CST Curation Set: 11892; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Curated Info
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165	Moritz A (2010) CST Curation Set: 9280; Year: 2010; Biosample/Treatment: cell line, MKN-45/DMSO &'\|\|' Su11274; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
166	Moritz A (2010) CST Curation Set: 9235; Year: 2010; Biosample/Treatment: cell line, MKN-45/calyculin_A & pervanadate; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
167	Moritz A (2010) CST Curation Set: 9241; Year: 2010; Biosample/Treatment: cell line, NCI-H1703/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
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170	Moritz A (2010) CST Curation Set: 8838; Year: 2010; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
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174	Moritz A (2010) CST Curation Set: 8865; Year: 2010; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
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184	Zhou J (2009) CST Curation Set: 7592; Year: 2009; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Curated Info
185	Zhou J (2009) CST Curation Set: 7591; Year: 2009; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Curated Info
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