Thr1114
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Home > Phosphorylation Site Page: > Thr1114  -  HIPK2 (human)

Site Information
APAALGStGTVAHLV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 28847906

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATM (human) ( 1 )
Putative in vivo kinases:
AMPKA2 (human) ( 1 )
Kinases, in vitro:
AMPKA1 (human) ( 1 )
Treatments:
cycloheximide ( 1 ) , ionizing_radiation ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on HIPK2:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein stabilization ( 1 )
Inhibit interaction with:
PPM1D (human) ( 1 )

References 

1

Choi DW, et al. (2013) WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation. Mol Cell 51, 374-85
23871434   Curated Info