Ser473
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Site Information
RPHFPQFsysAsGtA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447855

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 230 , 665 , 688 , 766 , 770 , 822 , 837 , 862 , 881 ) , electrophoretic mobility shift ( 183 , 851 , 877 ) , flow cytometry ( 11 , 283 , 437 , 548 , 747 ) , immunoassay ( 3 , 7 , 115 , 133 , 134 , 178 , 182 , 204 , 258 , 273 , 287 , 305 ) , immunoprecipitation ( 8 , 17 , 30 , 34 , 36 , 39 , 45 , 53 , 54 , 55 , 77 , 87 , 94 , 100 , 116 , 142 , 170 , 178 , 192 , 199 , 208 , 218 , 223 , 228 , 230 , 242 , 248 , 253 , 267 , 271 , 274 , 278 , 295 , 299 , 366 , 437 , 440 , 445 , 451 , 454 , 461 , 482 , 489 , 534 , 855 , 906 ) , mass spectrometry ( 8 , 18 , 94 , 122 , 142 , 167 , 198 , 205 , 212 , 213 , 214 , 234 , 291 , 292 , 293 , 294 , 319 , 320 , 323 , 324 , 325 , 326 , 327 , 338 , 339 , 346 , 347 , 348 , 349 , 354 , 355 , 356 , 357 , 358 , 359 , 360 , 372 , 373 , 378 , 379 , 389 , 391 , 394 , 395 , 396 , 397 , 398 , 404 , 408 , 413 , 416 , 435 , 572 ) , mass spectrometry (in vitro) ( 230 , 296 ) , microscopy-colocalization with upstream kinase ( 499 , 508 , 829 , 841 , 845 ) , mutation of modification site ( 2 , 8 , 13 , 14 , 16 , 17 , 18 , 29 , 53 , 55 , 95 , 142 , 146 , 150 , 160 , 162 , 172 , 179 , 181 , 183 , 230 , 267 , 274 , 371 , 429 , 437 , 440 , 455 , 481 , 484 , 505 , 507 , 509 , 529 , 568 , 571 , 579 , 636 , 665 , 686 , 695 , 696 , 709 , 715 , 741 , 750 , 765 , 770 , 815 , 829 , 837 , 845 , 855 , 861 , 893 , 903 , 904 , 910 , 913 , 923 , 924 , 926 ) , peptide sequencing ( 43 , 51 , 112 , 393 , 427 , 927 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 79 , 81 , 82 , 83 , 84 , 85 , 87 , 89 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 103 , 104 , 105 , 106 , 107 , 108 , 110 , 111 , 114 , 115 , 116 , 117 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 129 , 130 , 131 , 133 , 134 , 135 , 137 , 138 , 139 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 157 , 158 , 159 , 160 , 161 , 162 , 164 , 166 , 169 , 170 , 171 , 172 , 174 , 175 , 176 , 177 , 178 , 180 , 182 , 184 , 185 , 186 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 196 , 197 , 199 , 200 , 202 , 203 , 204 , 206 , 207 , 208 , 209 , 210 , 211 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 228 , 229 , 230 , 232 , 235 , 236 , 237 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 265 , 266 , 267 , 268 , 269 , 272 , 273 , 274 , 276 , 277 , 278 , 279 , 280 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 314 , 315 , 316 , 317 , 321 , 322 , 328 , 329 , 330 , 331 , 332 , 333 , 334 , 335 , 337 , 340 , 341 , 342 , 343 , 344 , 345 , 350 , 351 , 352 , 353 , 361 , 362 , 363 , 364 , 365 , 366 , 367 , 368 , 369 , 370 , 371 , 374 , 375 , 376 , 377 , 380 , 381 , 382 , 383 , 385 , 386 , 387 , 388 , 390 , 392 , 400 , 401 , 402 , 403 , 405 , 406 , 407 , 408 , 409 , 410 , 412 , 414 , 415 , 417 , 418 , 419 , 420 , 421 , 422 , 423 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 436 , 437 , 438 , 439 , 441 , 442 , 443 , 444 , 445 , 446 , 447 , 448 , 449 , 450 , 451 , 452 , 453 , 454 , 455 , 457 , 458 , 459 , 461 , 463 , 464 , 465 , 466 , 467 , 468 , 470 , 471 , 472 , 473 , 474 , 475 , 477 , 478 , 479 , 480 , 481 , 482 , 483 , 484 , 485 , 487 , 488 , 489 , 490 , 491 , 492 , 493 , 494 , 496 , 497 , 498 , 499 , 500 , 501 , 502 , 503 , 504 , 505 , 506 , 507 , 508 , 509 , 510 , 512 , 513 , 514 , 515 , 516 , 517 , 518 , 519 , 520 , 521 , 522 , 523 , 524 , 525 , 527 , 528 , 529 , 530 , 531 , 532 , 533 , 534 , 535 , 536 , 537 , 539 , 540 , 541 , 542 , 544 , 545 , 546 , 547 , 548 , 549 , 550 , 551 , 552 , 553 , 554 , 555 , 556 , 557 , 558 , 559 , 560 , 561 , 562 , 563 , 564 , 565 , 566 , 567 , 568 , 569 , 571 , 573 , 574 , 575 , 576 , 577 , 578 , 579 , 580 , 581 , 582 , 583 , 584 , 585 , 586 , 587 , 588 , 589 , 590 , 591 , 592 , 593 , 594 , 595 , 596 , 597 , 598 , 599 , 600 , 601 , 602 , 603 , 604 , 605 , 606 , 607 , 609 , 611 , 612 , 613 , 614 , 615 , 616 , 617 , 618 , 619 , 620 , 621 , 622 , 623 , 624 , 625 , 626 , 627 , 628 , 629 , 630 , 631 , 632 , 633 , 634 , 635 , 636 , 639 , 641 , 642 , 643 , 644 , 645 , 646 , 647 , 648 , 649 , 650 , 651 , 652 , 653 , 654 , 655 , 656 , 657 , 658 , 659 , 660 , 661 , 662 , 663 , 664 , 665 , 666 , 667 , 668 , 669 , 670 , 671 , 672 , 673 , 674 , 675 , 676 , 677 , 678 , 679 , 680 , 681 , 682 , 683 , 684 , 685 , 686 , 687 , 688 , 689 , 690 , 691 , 692 , 693 , 694 , 695 , 696 , 697 , 698 , 699 , 700 , 701 , 702 , 703 , 704 , 705 , 706 , 707 , 708 , 709 , 710 , 711 , 712 , 713 , 714 , 715 , 717 , 718 , 720 , 721 , 722 , 723 , 724 , 725 , 726 , 727 , 728 , 729 , 730 , 731 , 732 , 733 , 734 , 735 , 736 , 737 , 738 , 739 , 740 , 741 , 742 , 743 , 744 , 745 , 747 , 748 , 749 , 750 , 751 , 752 , 753 , 754 , 755 , 756 , 758 , 759 , 760 , 761 , 762 , 763 , 764 , 765 , 766 , 767 , 768 , 769 , 770 , 771 , 772 , 773 , 774 , 775 , 776 , 777 , 778 , 779 , 780 , 781 , 782 , 783 , 784 , 785 , 786 , 787 , 788 , 789 , 790 , 791 , 792 , 793 , 794 , 797 , 798 , 799 , 800 , 801 , 802 , 803 , 804 , 806 , 808 , 810 , 811 , 812 , 813 , 814 , 815 , 816 , 817 , 818 , 819 , 820 , 821 , 822 , 823 , 825 , 826 , 827 , 828 , 829 , 830 , 831 , 833 , 834 , 835 , 836 , 837 , 838 , 839 , 840 , 841 , 842 , 843 , 844 , 845 , 846 , 847 , 849 , 850 , 851 , 852 , 853 , 854 , 855 , 856 , 857 , 858 , 859 , 860 , 861 , 862 , 863 , 864 , 865 , 866 , 867 , 868 , 869 , 870 , 871 , 872 , 873 , 874 , 875 , 876 , 877 , 878 , 879 , 880 , 881 , 882 , 883 , 884 , 885 , 886 , 887 , 888 , 889 , 890 , 892 , 893 , 894 , 895 , 896 , 897 , 898 , 899 , 900 , 901 , 902 , 903 , 904 , 905 , 906 , 907 , 908 , 909 , 910 , 911 , 912 , 913 , 914 , 915 , 916 , 917 , 918 , 919 , 920 , 922 , 923 , 928 , 929 , 930 , 931 ) , phosphoamino acid analysis ( 231 , 281 , 384 , 511 , 855 ) , phosphopeptide mapping ( 837 ) , western blotting ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 79 , 81 , 82 , 83 , 84 , 85 , 87 , 89 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 103 , 104 , 105 , 106 , 107 , 108 , 110 , 111 , 112 , 114 , 115 , 116 , 117 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 129 , 130 , 131 , 133 , 134 , 135 , 137 , 138 , 139 , 141 , 142 , 143 , 144 , 145 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 157 , 158 , 159 , 160 , 161 , 162 , 164 , 166 , 169 , 170 , 171 , 172 , 174 , 175 , 176 , 177 , 178 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 191 , 192 , 193 , 194 , 196 , 197 , 199 , 200 , 202 , 203 , 204 , 206 , 207 , 208 , 209 , 210 , 211 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 228 , 229 , 230 , 231 , 232 , 235 , 236 , 237 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 266 , 267 , 268 , 269 , 271 , 272 , 273 , 274 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 284 , 286 , 288 , 289 , 290 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 314 , 315 , 317 , 321 , 322 , 328 , 329 , 330 , 331 , 332 , 333 , 334 , 335 , 337 , 341 , 342 , 343 , 344 , 345 , 350 , 351 , 352 , 353 , 361 , 362 , 363 , 364 , 365 , 366 , 367 , 368 , 369 , 370 , 371 , 374 , 375 , 376 , 377 , 380 , 381 , 382 , 383 , 384 , 385 , 386 , 387 , 388 , 390 , 392 , 393 , 400 , 401 , 402 , 403 , 405 , 406 , 407 , 408 , 409 , 412 , 414 , 417 , 418 , 419 , 420 , 421 , 422 , 423 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 436 , 437 , 438 , 439 , 440 , 441 , 442 , 443 , 444 , 445 , 446 , 447 , 448 , 450 , 451 , 452 , 453 , 454 , 455 , 457 , 459 , 461 , 463 , 464 , 465 , 466 , 467 , 468 , 470 , 471 , 472 , 473 , 474 , 475 , 478 , 479 , 480 , 481 , 482 , 483 , 484 , 485 , 487 , 488 , 489 , 490 , 491 , 492 , 493 , 494 , 496 , 497 , 498 , 499 , 500 , 501 , 502 , 503 , 504 , 505 , 506 , 507 , 508 , 509 , 510 , 511 , 512 , 513 , 514 , 515 , 516 , 517 , 518 , 519 , 520 , 521 , 522 , 523 , 524 , 525 , 527 , 528 , 529 , 530 , 531 , 532 , 533 , 534 , 535 , 536 , 537 , 539 , 540 , 541 , 542 , 544 , 545 , 546 , 547 , 549 , 550 , 551 , 552 , 553 , 554 , 555 , 556 , 557 , 558 , 560 , 561 , 562 , 563 , 564 , 565 , 567 , 568 , 569 , 571 , 573 , 574 , 575 , 576 , 577 , 578 , 579 , 580 , 581 , 582 , 583 , 584 , 585 , 586 , 587 , 588 , 589 , 591 , 592 , 593 , 594 , 595 , 596 , 597 , 598 , 599 , 600 , 601 , 602 , 603 , 604 , 605 , 606 , 607 , 609 , 611 , 612 , 613 , 614 , 615 , 616 , 617 , 618 , 619 , 621 , 622 , 623 , 624 , 625 , 626 , 627 , 628 , 630 , 631 , 632 , 633 , 634 , 635 , 636 , 639 , 641 , 642 , 643 , 644 , 645 , 647 , 648 , 649 , 650 , 651 , 652 , 655 , 656 , 657 , 658 , 659 , 660 , 661 , 663 , 666 , 668 , 669 , 671 , 679 , 680 , 684 , 686 , 687 , 690 , 691 , 692 , 695 , 697 , 699 , 701 , 703 , 704 , 705 , 706 , 707 , 708 , 709 , 710 , 713 , 714 , 717 , 718 , 720 , 721 , 725 , 726 , 727 , 729 , 730 , 732 , 733 , 734 , 735 , 736 , 738 , 739 , 741 , 743 , 749 , 750 , 751 , 758 , 759 , 760 , 761 , 764 , 766 , 767 , 768 , 769 , 770 , 772 , 774 , 775 , 778 , 779 , 780 , 781 , 783 , 784 , 785 , 788 , 789 , 790 , 791 , 792 , 793 , 797 , 798 , 799 , 801 , 803 , 804 , 806 , 808 , 810 , 812 , 814 , 815 , 817 , 819 , 820 , 821 , 823 , 826 , 828 , 829 , 830 , 831 , 833 , 834 , 835 , 837 , 838 , 839 , 840 , 842 , 843 , 845 , 846 , 847 , 849 , 850 , 852 , 854 , 855 , 856 , 860 , 861 , 863 , 864 , 865 , 867 , 868 , 870 , 872 , 875 , 878 , 887 , 888 , 890 , 893 , 899 , 900 , 903 , 904 , 905 , 906 , 907 , 908 , 909 , 910 , 911 , 912 , 913 , 914 , 915 , 916 , 917 , 918 , 919 , 923 , 927 , 928 , 929 , 930 , 931 )
Disease tissue studied:
ataxia-telangiectasia ( 322 ) , adrenal cancer ( 170 , 759 , 829 , 842 ) , pheochromocytoma ( 170 , 759 , 829 , 842 ) , bladder cancer ( 134 , 280 , 503 , 627 ) , bone cancer ( 86 , 161 , 180 , 202 , 278 , 369 , 387 , 414 , 450 , 463 , 521 , 542 , 587 , 699 ) , Ewing's sarcoma ( 521 ) , osteosarcoma ( 369 ) , brain cancer ( 36 , 45 , 52 , 98 , 110 , 193 , 258 , 260 , 276 , 302 , 315 , 350 , 367 , 370 , 381 , 414 , 417 , 444 , 455 , 588 , 589 , 605 , 612 , 650 , 651 , 666 , 688 , 736 , 750 , 762 , 862 , 899 , 911 , 931 ) , astrocytoma ( 688 , 862 ) , glioblastoma ( 36 , 45 , 52 , 98 , 110 , 258 , 260 , 276 , 302 , 315 , 350 , 367 , 414 , 455 , 588 , 589 , 605 , 612 , 650 , 651 , 666 , 736 , 750 , 762 , 899 , 911 ) , glioblastoma multiforme ( 142 , 193 , 258 , 260 , 315 , 381 , 444 , 612 , 650 , 762 ) , glioma ( 4 , 36 , 45 , 52 , 98 , 110 , 142 , 193 , 258 , 260 , 276 , 302 , 315 , 350 , 367 , 381 , 414 , 444 , 455 , 588 , 589 , 605 , 612 , 650 , 651 , 666 , 736 , 750 , 762 , 899 , 911 ) , medulloblastoma ( 417 ) , Schwannoma ( 370 , 931 ) , breast cancer ( 7 , 13 , 14 , 30 , 38 , 41 , 43 , 55 , 83 , 93 , 97 , 111 , 142 , 145 , 147 , 149 , 150 , 153 , 162 , 171 , 175 , 176 , 189 , 204 , 206 , 211 , 219 , 221 , 223 , 230 , 232 , 249 , 253 , 255 , 257 , 268 , 272 , 274 , 277 , 282 , 289 , 297 , 299 , 301 , 309 , 311 , 335 , 337 , 344 , 364 , 367 , 371 , 374 , 376 , 383 , 387 , 388 , 393 , 407 , 412 , 414 , 418 , 420 , 430 , 434 , 443 , 445 , 448 , 451 , 453 , 454 , 457 , 463 , 472 , 479 , 489 , 493 , 500 , 505 , 507 , 508 , 509 , 515 , 534 , 553 , 558 , 574 , 583 , 603 , 606 , 614 , 616 , 625 , 627 , 634 , 641 , 646 , 657 , 660 , 680 , 691 , 697 , 705 , 713 , 734 , 745 , 748 , 772 , 779 , 788 , 803 , 821 , 841 , 846 , 847 , 852 , 870 , 904 ) , breast adenocarcinoma ( 7 , 41 , 150 , 175 , 176 , 189 , 223 , 268 , 387 , 445 , 463 , 841 ) , breast cancer, triple negative ( 145 , 150 , 175 , 176 , 189 , 223 , 268 , 445 , 463 ) , cervical cancer ( 277 , 382 , 509 , 725 , 843 ) , cervical adenocarcinoma ( 509 , 843 ) , colorectal cancer ( 7 , 8 , 51 , 58 , 70 , 81 , 146 , 166 , 182 , 217 , 230 , 250 , 277 , 278 , 297 , 330 , 409 , 470 , 472 , 487 , 491 , 503 , 512 , 560 , 571 , 630 , 660 , 726 , 839 , 850 , 865 ) , colorectal carcinoma ( 7 , 8 , 51 , 58 , 70 , 81 , 146 , 166 , 182 , 217 , 230 , 250 , 277 , 278 , 297 , 330 , 409 , 470 , 472 , 487 , 491 , 503 , 512 , 560 , 571 , 630 , 660 , 726 , 839 , 850 , 865 ) , endometrial cancer ( 12 , 307 , 431 ) , endometrial adenocarcinoma ( 12 , 307 , 431 ) , gastric cancer ( 143 , 152 , 220 , 319 , 320 , 323 , 346 , 348 , 349 , 356 , 357 , 389 , 394 , 395 , 396 , 408 , 421 , 435 , 461 , 514 , 528 , 764 ) , gastric carcinoma ( 143 , 152 , 220 , 319 , 320 , 323 , 346 , 348 , 349 , 356 , 357 , 389 , 394 , 395 , 396 , 408 , 421 , 435 , 461 , 514 , 528 ) , gestational cancer ( 300 ) , gestational trophoblastic choriocarcinoma ( 300 ) , GIST ( 764 ) , HNSCC ( 196 ) , kidney cancer ( 10 , 177 , 181 , 430 , 471 , 661 ) , papillary kidney cancer ( 91 ) , leukemia ( 5 , 47 , 50 , 62 , 66 , 106 , 108 , 194 , 207 , 237 , 271 , 380 , 391 , 419 , 478 , 490 , 513 , 536 , 546 , 646 , 695 , 713 , 767 , 831 , 914 , 916 ) , acute lymphocytic leukemia ( 546 ) , acute myelogenous leukemia ( 47 , 50 , 194 , 380 , 478 , 513 , 536 , 646 , 713 , 914 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 106 , 490 , 646 , 916 ) , chronic lymphocytic leukemia ( 831 ) , chronic myelogenous leukemia ( 22 , 62 , 66 , 391 , 419 , 695 ) , T cell leukemia ( 5 , 207 , 237 , 271 ) , liver cancer ( 37 , 39 , 80 , 87 , 100 , 121 , 139 , 144 , 218 , 244 , 245 , 269 , 285 , 366 , 401 , 402 , 425 , 517 , 529 , 586 , 596 , 606 , 611 , 642 , 704 , 707 , 717 , 804 ) , hepatocellular carcinoma ( 48 , 80 , 100 , 130 , 139 , 245 , 278 , 366 ) , squamous cell carcinoma of the liver ( 244 , 402 ) , lung cancer ( 3 , 7 , 19 , 21 , 28 , 56 , 58 , 70 , 79 , 85 , 89 , 103 , 115 , 117 , 119 , 120 , 137 , 190 , 197 , 215 , 220 , 230 , 235 , 243 , 246 , 272 , 278 , 289 , 324 , 325 , 326 , 327 , 330 , 343 , 347 , 352 , 354 , 355 , 358 , 359 , 360 , 364 , 378 , 379 , 397 , 408 , 414 , 439 , 449 , 453 , 457 , 458 , 470 , 488 , 491 , 498 , 530 , 541 , 586 , 609 , 633 , 634 , 639 , 659 , 675 , 687 , 761 , 774 , 889 ) , non-small cell lung cancer ( 3 , 7 , 19 , 21 , 28 , 33 , 56 , 58 , 70 , 79 , 85 , 89 , 103 , 117 , 119 , 120 , 137 , 190 , 197 , 220 , 230 , 235 , 278 , 324 , 325 , 326 , 327 , 343 , 347 , 352 , 354 , 355 , 358 , 359 , 360 , 378 , 379 , 397 , 408 , 439 , 449 , 453 , 491 , 530 , 541 , 633 , 634 , 639 , 659 , 687 , 889 ) , non-small cell lung adenocarcinoma ( 3 , 7 , 19 , 21 , 28 , 56 , 58 , 79 , 85 , 89 , 117 , 119 , 120 , 137 , 190 , 220 , 278 , 326 , 327 , 347 , 354 , 355 , 358 , 359 , 360 , 397 , 408 ) , non-small cell large cell lung carcinoma ( 19 , 28 , 119 , 190 , 235 ) , non-small cell squamous cell lung carcinoma ( 326 , 327 , 347 , 397 , 408 , 491 ) , lymphoma ( 29 , 116 , 135 , 207 , 283 , 375 , 385 , 386 , 468 , 531 , 546 , 595 , 623 , 646 , 728 , 812 , 819 ) , anaplastic large cell lymphoma ( 283 , 375 , 546 ) , B cell lymphoma ( 16 , 29 , 116 , 207 , 595 , 819 ) , Burkitt's lymphoma ( 595 ) , Hodgkin's lymphoma ( 386 , 728 ) , non-Hodgkin's lymphoma ( 29 , 207 ) , mantle cell lymphoma ( 29 , 207 ) , PEL ( 135 ) , T cell lymphoma ( 283 , 375 , 385 , 623 ) , neuroblastoma ( 84 , 122 , 248 , 261 , 273 , 279 , 482 , 516 , 540 , 588 , 607 , 644 , 758 , 759 , 801 , 828 , 830 , 875 , 929 ) , ovarian cancer ( 34 , 57 , 71 , 123 , 124 , 153 , 242 , 251 , 277 , 297 , 340 , 363 , 370 , 390 , 477 , 544 , 563 , 591 , 594 , 668 , 757 , 779 , 846 , 868 ) , ovarian epithelial carcinoma ( 544 ) , pancreatic cancer ( 15 , 23 , 33 , 58 , 59 , 73 , 75 , 78 , 192 , 265 , 278 , 306 , 311 , 367 , 470 , 525 , 615 , 690 , 714 , 738 ) , pancreatic carcinoma ( 15 , 23 , 59 , 73 , 75 , 78 , 192 , 278 , 306 , 311 , 367 , 470 , 525 , 615 , 690 , 714 , 738 ) , pancreatic islet cell cancer ( 33 ) , multiple myeloma ( 20 , 67 ) , prostate cancer ( 18 , 45 , 87 , 94 , 101 , 116 , 199 , 200 , 208 , 236 , 244 , 251 , 256 , 272 , 273 , 277 , 297 , 310 , 334 , 345 , 416 , 427 , 453 , 463 , 464 , 465 , 466 , 472 , 506 , 515 , 539 , 618 , 626 , 632 , 645 , 656 , 718 , 750 , 753 , 768 , 792 , 865 , 913 , 917 , 930 ) , melanoma skin cancer ( 65 , 210 , 353 , 428 , 437 , 507 , 624 , 630 , 652 , 741 , 823 ) , small intestine cancer ( 764 ) , fibrosarcoma of soft tissue ( 107 , 288 , 330 , 501 , 503 , 838 , 865 ) , leiomyosarcoma ( 288 , 307 ) , rhabdomyosarcoma ( 44 , 159 , 521 , 545 , 790 ) , cancer, squamous cell carcinoma ( 182 , 196 , 244 , 314 , 382 ) , thyroid cancer ( 617 , 709 ) , anaplastic thyroid carcinoma ( 709 ) , follicular thyroid carcinoma ( 617 , 709 ) , papillary thyroid carcinoma ( 709 ) , diabetes mellitus ( 533 ) , type 2 diabetes ( 290 , 533 ) , hepatitis ( 510 ) , neurofibromatosis type 1 ( 406 ) , Parkinson's disease ( 426 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 150 ) , 'brain, caudate-putamen' ( 540 ) , 'brain, cerebellum' ( 417 ) , 'brain, cerebrum' ( 182 ) , 'brain, midbrain' ( 426 ) , 'hematopoietic progenitor, CD34+'-blood ( 281 ) , 'macrophage, alveolar'-lung ( 896 ) , 'muscle, skeletal' ( 151 , 155 , 158 , 284 , 290 , 303 , 496 , 502 , 533 , 545 , 550 , 613 , 649 , 653 , 670 , 673 , 684 , 693 , 694 , 703 , 704 , 730 ) , 'muscle, skeletal' [SGK1 (human), homozygous knockout] ( 729 ) , 'muscle, smooth' ( 730 ) , 'neuron, cortical'-brain ( 664 ) , 'neuron, dorsal root ganglion'-brain ( 749 ) , 'neuron, hippocampal'-brain ( 664 ) , 'stem, breast cancer' ( 148 ) , 'stem, embryonic' ( 203 , 368 ) , 'stem, mesenchymal' ( 24 ) , 'stem, prostate cancer' ( 35 ) , 1-LN (prostate cell) ( 199 ) , 1321N1 (glial) ( 884 ) , 201T ('epithelial, lung') ( 246 ) , 21T (breast cell) ( 367 ) , 22Rv1 (prostate cell) ( 506 ) , 293 (epithelial) [ADRB2 (human), transfection] ( 494 ) , 293 (epithelial) [MDM2 (human)] ( 750 ) , 293 (epithelial) [Raptor (human), transfection] ( 295 ) , 293 (epithelial) ( 7 , 77 , 92 , 106 , 149 , 157 , 182 , 187 , 192 , 193 , 229 , 252 , 267 , 321 , 332 , 334 , 377 , 392 , 405 , 410 , 414 , 423 , 430 , 437 , 438 , 441 , 442 , 444 , 455 , 457 , 459 , 473 , 474 , 492 , 511 , 520 , 527 , 540 , 547 , 554 , 579 , 582 , 585 , 600 , 621 , 634 , 642 , 648 , 662 , 665 , 667 , 677 , 689 , 700 , 705 , 721 , 738 , 745 , 768 , 784 , 786 , 806 , 845 , 854 , 857 , 874 , 882 , 894 , 900 , 902 , 918 , 923 , 927 ) , 293E (epithelial) ( 217 , 224 , 571 , 676 ) , 293GP (epithelial) ( 66 ) , 2C4 (fibroblast) ( 876 ) , 2fTGH (fibroblast) ( 876 ) , 32D (myeloid) ( 634 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 770 , 771 , 784 , 818 , 840 , 869 , 879 ) , 3T3 (fibroblast) [Src (human)] ( 609 ) , 3T3 (fibroblast) ( 87 , 180 , 193 , 230 , 437 , 484 , 524 , 541 , 660 , 665 , 843 , 924 ) , 3T3-L1 (fibroblast) ( 174 , 550 , 575 , 717 ) , 41M (ovarian) ( 591 ) , 769P (renal) ( 10 , 814 ) , 786-O (renal) ( 10 , 181 ) , A172 (glial) ( 110 , 589 , 681 ) , A2780 (ovarian) ( 277 , 544 , 754 ) , A293T ('renal, embryonic') ( 565 ) , A375 (melanocyte) ( 65 , 210 , 428 , 624 , 630 ) , A427 (pulmonary) ( 19 ) , A431 (epithelial) ( 58 , 352 , 552 , 702 , 721 ) , A498 (renal) ( 814 ) , A549 (pulmonary) [SRXN1 (human), transfection] ( 498 ) , A549 (pulmonary) ( 3 , 19 , 21 , 28 , 56 , 58 , 79 , 85 , 89 , 119 , 120 , 190 , 197 , 215 , 220 , 246 , 272 , 278 , 330 , 343 , 364 , 408 , 414 , 439 , 457 , 458 , 470 , 488 , 491 , 530 , 541 , 586 , 633 , 639 , 675 , 702 , 712 , 761 , 774 ) , ACE (endothelial) ( 833 ) , ACHN (renal) ( 814 ) , ACN ( 84 ) , adipocyte-adipose tissue ( 6 , 49 , 706 ) , adipose tissue ( 76 , 562 ) , AGS (gastric) [CCKBR (human), transfection] ( 421 ) , AGS (gastric) ( 143 , 461 , 528 ) , AML10 (myeloid) ( 50 ) , AML11 (myeloid) ( 50 ) , AN3-CA (endometrial) ( 307 ) , AR42J (pancreatic) ( 615 ) , artery-heart ( 635 ) , Aspc1 (pancreatic) ( 15 , 73 , 78 , 738 ) , astrocyte ( 127 ) , astrocyte [p16-INK4A (human), homozygous knockout] ( 193 ) , astrocyte-'brain, striatum' ( 808 ) , AT52RM (lymphoblastoid) ( 322 ) , AU565 (breast cell) ( 189 , 268 , 583 ) , B lymphocyte ( 595 , 831 ) , B lymphocyte-spleen ( 585 ) , BAEC (endothelial) ( 492 , 568 , 576 , 578 , 621 , 686 , 735 , 783 , 789 , 799 , 820 , 867 , 890 , 895 ) , BaF3 ('B lymphocyte, precursor') [EGFR (human)] ( 609 ) , BaF3 ('B lymphocyte, precursor') ( 3 , 47 , 66 , 317 ) , BC3 (B lymphocyte) ( 135 ) , BE (melanocyte) ( 741 ) , BEAS-2B (epithelial) ( 61 , 634 ) , BEL7402 (hepatic) ( 39 ) , Ben-Men-1 ( 931 ) , BeWo31 ( 446 ) , BeWo ( 446 ) , BG-1 ( 374 ) , BHK (fibroblast) [HRas (human)] ( 559 ) , BHK (fibroblast) [KRas (human)] ( 559 ) , BHK (fibroblast) [Sin1 (human)] ( 559 ) , BJ (fibroblast) ( 599 ) , blood ( 144 ) , Bon1 (pancreatic) ( 33 ) , bone marrow ( 170 , 766 ) , BPH-1 (epithelial) ( 334 ) , brain ( 258 , 588 ) , breast ( 7 , 420 , 680 ) , breast cell ( 186 ) , breast cell-breast ( 148 , 841 ) , BT-474 (breast cell) ( 7 , 14 , 43 , 111 , 153 , 176 , 268 , 277 , 289 , 311 , 367 , 558 , 583 , 697 , 722 , 852 ) , BT-549 (breast cell) ( 175 , 176 , 371 , 660 ) , BxPC-3 (pancreatic) ( 311 , 738 ) , C2C12 (myoblast) [SPRY2 (human), transfection] ( 669 ) , C2C12 (myoblast) ( 44 , 669 , 730 , 790 ) , C33-A (cervical) ( 277 , 725 ) , C4-2 (prostate cell) ( 427 ) , Caco-2 (intestinal) ( 630 ) , Caki-1 (renal) ( 471 , 814 ) , Calu-1 (squamous) ( 235 , 278 , 439 , 541 ) , CAMA-1 (breast cell) ( 41 ) , Caov-3 (ovarian) ( 591 ) , Capan1 (pancreatic) ( 59 , 738 ) , Capan2 (pancreatic) ( 68 ) , CCRF-CEM (T lymphocyte) ( 237 , 546 ) , CD18/HPAF (pancreatic) ( 59 ) , CEF ( 17 ) , cervix ( 182 ) , CFPAC-1 (pancreatic) ( 564 ) , CH27 (squamous) ( 869 ) , CHL (fibroblast) ( 888 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 818 , 923 ) , CHO (fibroblast) [EPOR (human)] ( 579 ) , CHO (fibroblast) [INSR (human), transfection] ( 903 ) , CHO (fibroblast) [MAS1 (human)] ( 593 ) , CHO (fibroblast) ( 40 , 376 , 550 , 665 , 732 , 801 ) , CHO-K1 (fibroblast) ( 150 ) , chondrocyte ( 422 ) , CL1-0 (pulmonary) ( 120 , 197 ) , CL1-5 (pulmonary) ( 56 ) , COLO-357 (pancreatic) ( 367 ) , colon ( 81 , 182 ) , COS (fibroblast) ( 484 , 493 , 565 , 568 , 615 , 655 , 686 , 692 , 724 , 749 , 770 , 815 , 829 , 834 , 837 , 842 , 865 , 874 , 885 , 894 , 895 , 897 , 904 , 906 , 919 , 926 ) , COS7 (fibroblast) ( 303 , 532 ) , CTL-EN (T lymphocyte) ( 778 ) , D425 ( 104 ) , Daoy ( 417 ) , DDT1-MF2 (myoblast) ( 864 ) , DF1 (fibroblast) ( 587 ) , DLBCL (B lymphocyte) ( 16 ) , DLD1 (intestinal) ( 8 , 250 , 278 , 409 , 503 , 660 , 682 ) , DM4 (melanocyte) ( 428 ) , DT40 (B lymphocyte) ( 595 ) , DU 145 (prostate cell) ( 199 , 273 , 453 , 465 , 472 , 552 , 792 , 859 , 880 , 917 ) , EA.hy 926 (endothelial) ( 129 , 873 , 907 ) , embryo ( 587 ) , endothelial-aorta ( 739 , 815 , 826 , 892 , 901 ) , endothelial-pulmonary artery ( 780 ) , endothelial-vein ( 744 , 835 , 893 ) , eosinophil ( 794 ) , epithelial ( 499 ) , epithelial-'kidney, tubule, proximal' ( 592 ) , epithelial-lens ( 328 ) , epithelial-prostate ( 645 ) , erythroblast ( 914 ) , ES (stem) ( 899 ) , ES2 (ovarian) ( 242 , 340 ) , ESC ( 452 ) , esophagus ( 182 ) , FaDu (squamous) ( 196 ) , Fao (hepatic) ( 550 ) , fibroblast ( 490 ) , fibroblast-embryo ( 183 , 187 , 429 ) , fibroblast-foreskin ( 142 , 774 ) , fibroblast-skin ( 727 ) , FL5.12 (lymphoid) ( 524 ) , Flow2000 ( 95 ) , Focus (hepatic) ( 130 ) , GBM39 (astrocyte) ( 193 ) , GI-101A (breast cell) ( 779 , 846 ) , GIST544 (gastric) ( 764 ) , GIST882 (gastric) ( 764 ) , glial ( 45 ) , glial-brain ( 98 ) , GM00637 (lymphoblast) ( 715 ) , GM07078 (lymphoblastoid) ( 322 ) , GM08391 (fibroblast) ( 715 ) , GM09607 (fibroblast) ( 715 ) , GRANTA-519 (B lymphocyte) ( 29 ) , GSCs (glial) ( 4 ) , GTL-16 (gastric) ( 408 ) , H19-7 (neuron) [IGF1R (human)] ( 681 ) , HaCaT (keratinocyte) ( 42 , 384 , 769 , 811 , 886 ) , HAEC (endothelial) ( 518 , 576 , 593 , 619 , 628 , 647 , 802 ) , HAK-1A (hepatic) ( 48 ) , HAK-1B (hepatic) ( 48 ) , HBEC3 (epithelial) ( 278 , 352 , 565 ) , HBL-100 (breast cell) ( 176 ) , HCC (hepatic) ( 278 ) , HCC1806 (breast cell) ( 145 ) , HCC1937 (breast cell) ( 534 ) , HCC44 (pulmonary) ( 278 ) , HCC827 (pulmonary) ( 3 , 119 ) , HCCLM3 (hepatic) ( 80 ) , HCN-2 ('neuron, cortical') ( 436 ) , HCT116 (intestinal) ( 7 , 8 , 51 , 58 , 70 , 81 , 166 , 182 , 230 , 277 , 278 , 330 , 409 , 470 , 472 , 491 , 503 , 512 , 682 , 839 ) , HCT15 (intestinal) ( 146 ) , HDMEC (endothelial) ( 286 ) , heart ( 303 , 387 , 475 ) , HEC-50B (endometrial) ( 307 ) , HEI-193 (Schwann) ( 370 , 931 ) , HEK293T (epithelial) ( 55 , 66 , 97 , 99 , 115 , 133 , 188 , 216 , 222 , 278 , 296 , 298 , 299 , 303 , 367 , 432 , 440 , 473 , 481 , 565 , 569 , 571 , 574 , 580 , 678 , 696 , 697 , 712 , 776 , 865 , 866 , 883 ) , HEL (erythroid) ( 490 ) , HeLa (cervical) ( 2 , 27 , 54 , 58 , 87 , 138 , 142 , 147 , 150 , 202 , 209 , 228 , 230 , 247 , 262 , 266 , 303 , 330 , 332 , 361 , 364 , 371 , 398 , 400 , 453 , 472 , 542 , 550 , 552 , 564 , 571 , 579 , 611 , 678 , 712 , 721 , 729 , 751 , 773 , 785 , 810 , 816 , 851 , 856 , 876 ) , HeLa S3 (cervical) ( 509 , 843 ) , hematopoietic progenitor-bone marrow ( 590 ) , Hepa 1-6 (epithelial) ( 218 ) , hepatocyte ( 187 , 425 ) , hepatocyte-liver ( 13 , 218 , 694 , 775 ) , HepG2 (hepatic) ( 37 , 39 , 87 , 144 , 218 , 269 , 285 , 401 , 425 , 517 , 529 , 575 , 586 , 596 , 606 , 611 , 673 , 704 , 707 , 737 , 804 , 858 ) , HEY (ovarian) ( 123 , 340 , 779 , 846 ) , HFF1 (fibroblast) ( 31 ) , HGS-396 ( 288 ) , HGS-446 ( 288 ) , HL60 (myeloid) ( 108 , 800 , 822 , 881 ) , HLMVECs ( 141 ) , HMEC (endothelial) ( 96 , 367 , 489 , 765 ) , HMVEC (endothelial) ( 672 , 836 ) , HN5 (squamous) ( 382 , 698 ) , HPAC (pancreatic) ( 75 ) , HPB-ALL (T lymphocyte) ( 812 ) , HPCA (prostate cell) ( 742 ) , HS294T (melanocyte) ( 428 ) , HSC (squamous) ( 244 , 402 ) , HSC-3 (squamous) ( 244 ) , HSC-4 (squamous) ( 244 ) , HT-29 (intestinal) ( 217 , 297 , 487 , 512 , 571 , 696 , 712 , 726 , 850 ) , HT1080 (fibroblast) ( 107 , 288 , 330 , 501 , 503 , 865 , 898 ) , hTERT-RPE1 (epithelial) ( 202 ) , HUES-1 ('stem, embryonic') ( 26 ) , HUES-7 ('stem, embryonic') ( 26 ) , HUES-9 ('stem, embryonic') ( 26 ) , Huh7 (hepatic) ( 139 , 245 , 366 , 517 , 642 ) , HUT-78 (T lymphocyte) ( 385 , 623 ) , HUVEC (endothelial) ( 82 , 125 , 126 , 311 , 341 , 362 , 403 , 467 , 474 , 480 , 483 , 503 , 509 , 577 , 597 , 604 , 619 , 631 , 663 , 672 , 686 , 732 , 763 , 774 , 781 , 782 , 791 , 825 , 861 , 872 , 878 , 879 , 881 , 885 , 907 , 908 , 910 , 928 ) , HUVEC (endothelial) [IRS1 (human)] ( 781 ) , IGROV1 (ovarian) ( 390 , 813 ) , IMR-90 (fibroblast) ( 8 , 197 , 599 ) , IMR32 (neural crest) ( 588 ) , IOSE-29 (ovarian) ( 813 ) , IOSE-398 (ovarian) ( 242 ) , IR983F (B lymphocyte) ( 819 ) , Ishikawa (endometrial) ( 307 , 431 ) , JAR (placental) ( 308 ) , JB (epithelial) ( 685 ) , JEG-3 (uterine) ( 300 ) , JEKO-1 (B lymphocyte) ( 29 , 207 ) , Jurkat (T lymphocyte) ( 5 , 167 , 205 , 207 , 271 , 291 , 292 , 293 , 294 , 331 , 338 , 339 , 372 , 373 , 385 , 404 , 413 , 546 , 572 , 581 , 623 , 683 , 733 , 740 , 747 , 812 , 819 , 855 , 869 , 912 ) , K562 (erythroid) ( 62 , 66 , 391 , 419 , 695 ) , Karpas-299 (T lymphocyte) ( 283 , 375 ) , Kasumi-1 (myeloid) ( 380 ) , KATO III (gastric) ( 408 , 435 ) , KCL22 (myeloid) ( 62 ) , KELLY (neural crest) ( 588 ) , keratinocyte ( 13 , 851 ) , keratinocyte-skin ( 798 ) , KG-1 (myeloid) ( 646 ) , kidney ( 430 , 471 ) , KLE (endometrial) ( 12 , 307 ) , KM-H2 (lymphoid) ( 728 ) , KPL-1 (breast cell) ( 277 ) , KPL-4 (breast cell) ( 189 ) , Ku-19-20 (renal) ( 814 ) , Kyse450 (squamous) ( 654 ) , L02 (hepatic) ( 121 , 172 , 231 ) , L1236 (lymphoid) ( 728 ) , L3.6p1 (pancreatic) ( 59 ) , L540 (lymphoid) ( 386 ) , L6 (myoblast) ( 158 , 550 , 670 , 849 , 927 ) , LAN-1 (neural crest) ( 482 ) , LCL (lymphoblastoid) ( 305 , 322 ) , Leio-177 ( 288 ) , leukocyte-blood ( 160 ) , liver ( 299 , 303 , 510 , 586 , 704 , 717 ) , LLC-PK1 (renal) ( 567 , 922 ) , LN-Z308 (glial) ( 605 ) , LN229 (glial) ( 45 , 52 , 258 , 260 , 350 , 650 ) , LNCaP (prostate cell) ( 94 , 101 , 116 , 200 , 256 , 272 , 310 , 345 , 416 , 463 , 472 , 506 , 539 , 618 , 626 , 632 , 750 , 760 , 768 , 814 , 913 , 917 , 930 ) , LS-513 (intestinal) ( 277 ) , lung ( 64 , 378 , 379 , 387 , 415 , 449 , 633 ) , lymphocyte-blood ( 11 , 22 , 855 ) , M-07e (myeloid) ( 767 ) , M059J (glial) ( 455 , 551 ) , M12 (B lymphocyte) ( 116 ) , M14-MEL (melanocyte) ( 652 ) , macrophage-blood ( 724 ) , macrophage-bone marrow ( 46 ) , mammary gland ( 660 ) , mast-bone marrow ( 585 ) , MCF-10A (breast cell) [GAB2 (human), transfection] ( 493 ) , MCF-10A (breast cell) ( 93 , 97 , 149 , 171 , 249 , 297 , 371 , 472 , 500 , 634 , 660 , 676 , 772 , 821 , 846 ) , MCF-7 (breast cell) [Akt1 (human)] ( 641 ) , MCF-7 (breast cell) [CYP19A1 (human)] ( 691 ) , MCF-7 (breast cell) [EGFR (human)] ( 641 ) , MCF-7 (breast cell) [MEK1 (human)] ( 641 ) , MCF-7 (breast cell) [Src (human)] ( 625 ) , MCF-7 (breast cell) ( 7 , 14 , 30 , 111 , 142 , 149 , 153 , 162 , 176 , 189 , 204 , 206 , 211 , 221 , 230 , 253 , 255 , 257 , 274 , 277 , 282 , 337 , 344 , 374 , 376 , 407 , 412 , 414 , 418 , 420 , 430 , 434 , 443 , 453 , 454 , 463 , 479 , 489 , 507 , 515 , 552 , 553 , 564 , 574 , 603 , 606 , 614 , 616 , 627 , 641 , 646 , 657 , 676 , 702 , 705 , 713 , 734 , 745 , 748 , 776 , 803 , 847 , 870 , 904 ) , MCF10A1 (epithelial) ( 53 , 148 , 175 , 257 ) , MDA-IBC-3 (breast cell) ( 189 ) , MDA-MB-231 (breast cell) ( 7 , 13 , 14 , 43 , 55 , 83 , 111 , 147 , 175 , 176 , 189 , 221 , 223 , 230 , 232 , 249 , 272 , 277 , 297 , 301 , 374 , 448 , 451 , 457 , 479 , 505 , 515 , 534 , 660 , 680 , 734 , 870 ) , MDA-MB-361 (breast cell) ( 7 , 176 , 369 , 387 , 852 ) , MDA-MB-435 (breast cell) ( 176 , 204 , 219 , 299 , 364 , 564 , 660 , 870 ) , MDA-MB-453 (breast cell) ( 176 , 472 , 564 , 852 ) , MDA-MB-468 (breast cell) ( 150 , 175 , 176 , 189 , 223 , 268 , 393 , 445 , 451 , 457 , 463 , 472 , 509 , 534 , 583 , 660 , 756 ) , MDAH2774 (ovarian) ( 564 ) , MDCK (epithelial) ( 856 , 860 ) , ME-180 (cervical) ( 382 ) , MEF (fibroblast) ( 7 , 77 , 87 , 142 , 164 , 216 , 217 , 230 , 258 , 266 , 278 , 303 , 405 , 440 , 455 , 540 , 541 , 551 , 571 , 660 ) , MEF (fibroblast) [BRCA1 (mouse), transgenic] ( 255 ) , MEF (fibroblast) [Etk (human), heterozygous knockout] ( 185 ) , MEF (fibroblast) [IGF1R (mouse)] ( 779 ) , MEF (fibroblast) [Myc (mouse)] ( 652 ) , MEF (fibroblast) [p70S6K (mouse), homozygous knockout] ( 368 ) , MEF (fibroblast) [RICTOR (human), homozygous knockout] ( 332 ) , MEF (fibroblast) [TSC22D2 (human)] ( 552 ) , MEL624 (melanocyte) ( 428 ) , melanocyte-skin [IKKB (mouse), homozygous knockout] ( 353 ) , mesangial ( 622 , 720 ) , mesenchymal ( 64 ) , MeWo (melanocyte) ( 428 , 624 ) , MFH-841 ( 288 ) , MFH-M ( 288 ) , MG63 (bone cell) ( 369 ) , MHCC97-L (hepatic) ( 80 ) , MIA PaCa (pancreatic) ( 552 ) , MIA PaCa-2 (pancreatic) ( 75 , 278 , 470 , 738 ) , microvessel endothelial ( 351 ) , MIN6 (pancreatic) ( 525 ) , MKN-45 (gastric) ( 198 , 319 , 320 , 323 , 346 , 348 , 349 , 356 , 357 , 389 , 394 , 395 , 396 , 528 ) , MKN-74 (gastric) ( 461 ) , ML-1 (myeloid) ( 617 ) , MOLT-4 (T lymphocyte) ( 623 ) , monocyte-blood ( 259 ) , mononuclear ( 433 , 602 ) , MPNST724 ( 288 ) , MRC5 (fibroblast) ( 85 , 503 ) , MSN (neuron) ( 755 ) , MTSV (epithelial) ( 710 ) , muscle ( 674 ) , Mv1Lu (pulmonary) ( 671 ) , MV4-11 (macrophage) ( 47 , 50 ) , myeloid ( 752 ) , myeloid-bone marrow ( 519 ) , myoblast ( 566 ) , myocyte-heart ( 643 , 658 , 793 , 887 ) , N1 ( 9 ) , NA (squamous) ( 244 ) , Namalwa (B lymphocyte) ( 595 ) , NB-4 (myeloid) ( 646 , 713 ) , NBS-ILB1 (fibroblast) ( 322 ) , NCI-H1299 (pulmonary) ( 70 , 119 , 197 , 230 , 439 , 491 , 639 ) , NCI-H157 (pulmonary) ( 70 , 230 , 235 , 439 , 453 , 541 , 696 ) , NCI-H1650 (pulmonary) ( 343 , 491 , 687 ) , NCI-H1666 (pulmonary) ( 633 ) , NCI-H1703 (squamous) ( 198 , 326 , 327 , 347 , 397 , 408 , 491 ) , NCI-H1781 (pulmonary) ( 634 ) , NCI-H1792 (pulmonary) ( 235 , 659 ) , NCI-H1819 (pulmonary) ( 352 ) , NCI-H1838 (pulmonary) ( 659 ) , NCI-H1975 (pulmonary) ( 3 , 7 , 28 , 137 , 190 , 343 , 687 ) , NCI-H1993 (pulmonary) ( 220 , 278 ) , NCI-H2073 (pulmonary) ( 278 ) , NCI-H23 (pulmonary) ( 197 , 491 ) , NCI-H292 (pulmonary) ( 190 , 243 , 289 ) , NCI-H3255 (pulmonary) ( 3 , 190 , 198 , 324 , 325 ) , NCI-H345 (pulmonary) ( 731 ) , NCI-H358 (pulmonary) ( 235 , 278 ) , NCI-H441 (pulmonary) ( 278 , 354 , 355 , 358 , 359 , 360 ) , NCI-H460 (pulmonary) ( 19 , 28 , 119 , 190 , 235 , 439 , 491 , 552 ) , NCI-H510 (pulmonary) ( 731 ) , NCI-H69 (pulmonary) ( 731 ) , NCI-H727 (epithelial) ( 33 ) , NCI-H929 (B lymphocyte) ( 67 ) , neuron-'brain, cerebellum' ( 759 ) , neuron-'brain, hippocampus' ( 241 , 828 ) , neuron-dorsal root ganglia ( 178 ) , neutrophil ( 555 , 561 , 797 , 881 , 900 ) , NL-17 (intestinal) ( 865 ) , NMuMG (epithelial) ( 184 ) , NSCLC (pulmonary) ( 889 ) , OAW28 (ovarian) ( 34 ) , OCI/AML3 (myeloid) ( 50 ) , OK (renal) ( 549 , 601 ) , oocyte ( 72 , 179 , 225 ) , osteoblast-calvarium ( 636 , 723 ) , OV2008 (ovarian) ( 242 ) , ovarian ( 594 ) , ovary ( 182 , 363 , 477 , 757 ) , OvCa433 ( 124 ) , OVCAR3 (ovarian) ( 34 , 251 , 390 , 563 , 564 , 754 ) , OVCAR4 (ovarian) ( 591 , 757 ) , OVCAR5 (ovarian) ( 390 , 591 , 757 ) , P116 (T lymphocyte) ( 385 ) , PAE (endothelial) ( 77 , 333 , 365 , 485 , 679 , 708 , 885 , 905 ) , PANC-1 (pancreatic) ( 73 , 75 , 306 , 367 , 470 , 690 ) , pancreas ( 73 , 714 , 738 , 743 ) , pancreatic ( 265 ) , pancreatic acini ( 629 ) , PC-12 (chromaffin) ( 170 , 681 , 759 , 829 , 842 ) , PC3 (prostate cell) [CD82 (human)] ( 645 ) , PC3 (prostate cell) ( 18 , 45 , 87 , 94 , 101 , 199 , 208 , 236 , 251 , 272 , 273 , 277 , 297 , 427 , 464 , 465 , 466 , 472 , 515 , 552 , 645 , 656 , 712 , 718 , 792 , 844 , 865 , 880 , 917 ) , PC9-IR (pulmonary) ( 137 ) , PEO4 (ovarian) ( 591 ) , PEO6 (ovarian) ( 591 ) , platelet-blood ( 131 , 447 , 504 , 535 , 584 , 777 , 863 , 909 ) , PLC/PRF/5 (hepatic) ( 121 ) , prostate ( 499 , 753 ) , QGP-1 (endocrine) ( 33 ) , QZG (hepatic) ( 231 ) , Rat1 (fibroblast) ( 551 ) , RAW 264.7 (macrophage) ( 296 ) , RCC4 (renal) ( 471 ) , RD (muscle cell) ( 44 , 159 ) , Rh1 (bone cell) ( 521 ) , Rh13 (muscle cell) ( 790 ) , Rh18 (muscle cell) ( 521 , 790 ) , Rh30 ('muscle, skeletal') ( 44 , 159 , 521 , 545 , 790 ) , Rh4 (muscle cell) ( 790 ) , Rh41 ( 521 ) , Rh5 (muscle cell) ( 790 ) , RMF (fibroblast) ( 31 ) , RPMI-8266 (plasma cell) ( 20 ) , RPTE (epithelial) ( 814 ) , RWP1 (pancreatic) ( 192 ) , RWPE1 (prostate cell) ( 420 ) , Saos-2 (bone cell) ( 662 ) , SB2 (melanocyte) ( 428 ) , SCC12 (keratinocyte) ( 871 ) , Schwann ( 481 ) , SF767 (glial) ( 36 ) , SGC7901 (gastric) ( 152 ) , SH-SY5Y (neural crest) ( 248 , 261 , 273 , 279 , 516 , 540 , 588 , 607 , 644 , 681 , 758 , 759 , 786 , 787 , 828 , 830 , 853 , 875 , 877 ) , SHEP (neuron) ( 588 , 755 , 929 ) , SK-LMS-1 (muscle cell) ( 288 ) , SK-LU-1 (pulmonary) ( 278 ) , SK-MEL-23 (melanocyte) ( 437 ) , SK-MEL2 (melanocyte) ( 428 ) , SK-MEL28 (melanocyte) ( 74 ) , SK-MEL5 (melanocyte) ( 428 ) , SK-N-BE(2) (neural crest) ( 588 ) , SK-N-MC (neural crest) ( 122 , 755 ) , SKBr3 (breast cell) ( 38 , 43 , 176 , 189 , 289 , 371 , 388 , 457 , 505 , 508 , 564 , 722 , 788 , 852 ) , SKBR7 (breast cell) ( 55 ) , skin ( 42 , 428 , 823 ) , SKNSH (neural crest) ( 588 , 801 ) , SKOV-3 (ovarian) ( 57 , 71 , 153 , 242 , 251 , 297 , 340 , 370 , 390 , 591 , 594 , 668 , 757 , 813 , 837 , 868 ) , SKRC-44 (renal) ( 661 , 814 ) , SKRC-49 (renal) ( 814 ) , SKUT-1 ( 307 ) , SN12C (renal) ( 177 ) , SNB-19 (glial) ( 650 , 666 ) , SNU-1 (gastric) ( 528 ) , SNU-484 (gastric) ( 514 ) , SNU-5 (gastric) ( 220 ) , SNU-620 (gastric) ( 514 ) , SNU16Ad (gastric) ( 461 ) , SR (T lymphocyte) ( 375 ) , SRB-1 (squamous) ( 811 ) , ST88-14 (neuron) ( 406 ) , SU-DHL1 (T lymphocyte) ( 375 ) , Su.86.86 (pancreatic) ( 23 , 73 ) , SUM149 (breast cell) ( 189 ) , SUM159 (breast cell) ( 189 , 534 ) , SUM190 (breast cell) ( 189 ) , SUP-M2 (T lymphocyte) ( 283 ) , SV40 ( 672 ) , SW-1573 (pulmonary) ( 190 , 530 ) , SW1353 ( 86 ) , SW1463 (intestinal) ( 277 ) , SW1990 (pancreatic) ( 75 ) , SW48 (intestinal) ( 146 , 726 ) , SW480 (intestinal) ( 660 ) , SW620 (intestinal) ( 146 , 560 ) , SW684 ( 288 ) , synoviocyte-synovium ( 522 ) , T lymphocyte ( 63 , 254 ) , T lymphocyte-blood ( 263 , 522 , 548 , 557 , 573 , 598 , 817 ) , T/C-28a2 (chondrocyte) ( 342 ) , T24 (bladder cell) ( 134 , 280 , 503 , 627 ) , T47D (breast cell) ( 30 , 41 , 142 , 176 , 277 , 309 , 335 , 383 , 388 , 454 , 508 , 564 , 779 , 920 ) , T98G (glial) ( 142 , 260 , 315 , 612 , 762 , 876 ) , TF-1 (erythroid) ( 106 , 646 , 916 ) , THP1 (myeloid) ( 478 , 536 ) , thymus ( 316 ) , thyroid ( 709 , 829 ) , TPC-1 (thyroid cell) ( 709 ) , Tsu (prostate cell) ( 244 , 859 ) , U-118MG (glial) ( 36 ) , U-251 MG (glial) ( 36 , 98 , 315 , 605 , 650 , 651 , 666 ) , U-937 (myeloid) ( 468 , 531 , 646 , 752 , 812 ) , U2OS (bone cell) [GR (human)] ( 699 ) , U2OS (bone cell) ( 161 , 180 , 202 , 278 , 387 , 414 , 450 , 463 , 542 , 587 ) , U373 MG (glial) ( 381 , 444 , 650 ) , U4A (fibroblast) ( 876 ) , U87MG (glial) [EGFR (human), transfection] ( 350 ) , U87MG (glial) ( 36 , 98 , 110 , 276 , 302 , 367 , 414 , 588 , 589 , 650 , 651 , 666 , 688 , 736 , 750 , 862 , 899 , 911 ) , UACC-257 (melanocyte) ( 428 ) , UCSD-354L (melanocyte) ( 428 ) , UI.wt (fibroblast) ( 838 ) , UMSCC1 (squamous) ( 196 , 314 ) , UMSCC11A (squamous) [YAP1 (human), transfection] ( 314 ) , UMSCC11A (squamous) ( 314 ) , UMSCC11B (squamous) ( 314 ) , UMSCC22A (squamous) ( 314 ) , UMSCC22B (squamous) ( 314 ) , UMSCC38 (squamous) ( 314 ) , UMSCC46 (squamous) ( 314 ) , UMSCC6 (squamous) ( 314 ) , UMSCC9 (squamous) ( 314 ) , UT-7 (myeloid) [EPO (human), transfection] ( 914 ) , UT-7 (myeloid) ( 194 , 513 ) , vascular smooth muscle cell ('muscle, smooth') ( 537 , 660 ) , VSMC ('muscle, smooth') ( 169 ) , VSMC-aorta ( 329 ) , WI-38 (fibroblast) ( 463 ) , WiDr (epithelial) ( 51 ) , WM-1552 (melanocyte) ( 428 ) , WM115 (melanocyte) ( 823 ) , WM1799 (melanocyte) ( 428 ) , WM2664 (melanocyte) ( 428 ) , WM3211 (melanocyte) ( 428 ) , WM35 (melanocyte) ( 428 , 507 , 624 ) , WM46 (melanocyte) ( 428 ) , WM793 ( 297 ) , ZR-75-1 (breast cell) ( 41 , 176 , 606 )

Upstream Regulation
Regulatory protein:
14-3-3 zeta (human) ( 204 ) , 4E-BP1 (human) ( 511 ) , Ack (human) ( 80 , 98 , 420 ) , ACPP (human) ( 345 ) , AFAP1L2 (human) ( 460 ) , AFP (human) ( 121 ) , Akt1 (human) ( 8 , 98 , 117 , 225 , 256 , 279 , 297 , 483 , 484 , 523 , 586 , 641 , 814 , 852 , 854 , 855 , 911 ) , Akt2 (human) ( 136 , 256 , 484 ) , ALK (human) ( 862 ) , AMIGO2 (human) ( 82 ) , AMPKA1 (human) ( 7 , 344 , 597 ) , AMPKA2 (human) ( 679 ) , AR (human) ( 256 ) , ARAF (human) ( 599 ) , ATM (human) ( 715 ) , ATP6V1B2 (mouse) ( 600 ) , AurA (human) ( 461 ) , axin 1 (mouse) ( 241 ) , Bcr (human) ( 16 ) , beclin 1 (human) ( 83 ) , BMF (human) ( 210 ) , BRAF (human) ( 428 ) , Brk (human) ( 334 ) , BTG2 (human) ( 249 ) , Btk (human) ( 595 ) , CA9 (human) ( 661 ) , CAMKK1 (human) ( 854 ) , CAMKK2 (human) ( 7 ) , caveolin-1 (human) ( 159 ) , CCKBR (human) ( 615 ) , CD10 (human) ( 321 ) , CD133 (human) ( 99 ) , CD82 (human) ( 645 ) , CDC25B (human) ( 453 ) , CDC37 (human) ( 114 ) , CDK1 (human) ( 26 ) , CDK5 (human) ( 94 , 123 ) , CHKA (human) ( 479 ) , CHKB (human) ( 479 ) , CIP2A (human) ( 149 ) , CK1E (human) ( 157 ) , CPNE3 (human) ( 388 ) , CSF2RB (human) ( 778 ) , CXCR4 (human) ( 119 ) , CYP3A5 (human) ( 100 ) , CYR61 (human) ( 381 ) , DARPP-32 (human) ( 528 ) , DDIT4 (human) ( 700 ) , DDIT4L (human) ( 700 ) , DDX5 (human) ( 81 ) , DOK2 (human) ( 692 ) , DYRK2 (human) ( 30 ) , E4 (adenovirus) ( 774 ) , EFNA2 (human) ( 297 ) , EGFR (human) ( 449 , 459 , 633 , 641 ) , eNOS (mouse) ( 483 ) , Epac1 (human) ( 199 , 494 ) , Epiregulin (human) ( 249 ) , EPOR (human) ( 194 ) , ER-alpha (human) ( 252 , 376 ) , ER-beta (human) ( 580 ) , ERK1 (human) ( 577 , 579 ) , ERK2 (human) ( 223 , 577 , 579 ) , ERK5 (human) ( 365 ) , Etk (human) ( 185 ) , FAK (human) ( 560 ) , FHIT (human) (