Ser51
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser51  -  p63 (human)

Site Information
TQtNEFLsPEVFQHI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 28802100

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 1 ) , lung cancer ( 1 , 2 ) , non-small cell lung cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 2 ) , JNK1 (human) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on p63:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, altered ( 1 ) , transcription, altered ( 1 ) , transcription, inhibited ( 2 )
Induce interaction with:
PIN1 (human) ( 1 )
Inhibit interaction with:
p300 (human) ( 2 )

References 

1

Fan X, et al. (2021) Pin1 and JNK1 cooperatively modulate TAp63γ. FEBS Open Bio
33548094   Curated Info

2

Liao JM, et al. (2013) IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity. J Biol Chem 288, 18184-93
23589370   Curated Info