Ser552
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Home > Phosphorylation Site Page: > Ser552  -  Kv4.2 (rat)

Site Information
VSGsHRGsVQELSTI   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450462

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 2 ) , 'neuron, hippocampal' ( 3 ) , 'neuron, hippocampal'-brain ( 1 ) , COS (fibroblast) ( 4 ) , neuron-'brain, hippocampus' ( 4 )

Upstream Regulation
Regulatory protein:
PKACA (rat) ( 1 )
Putative in vivo kinases:
PKACA (human) ( 3 )
Treatments:
AMPA ( 3 ) , H-89 ( 3 )

Downstream Regulation
Effects of modification on Kv4.2:
intracellular localization ( 3 , 4 )

References 

1

Nestor MW, Hoffman DA (2012) Differential cycling rates of Kv4.2 channels in proximal and distal dendrites of hippocampal CA1 pyramidal neurons. Hippocampus 22, 969-80
21472817   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Hammond RS, et al. (2008) Protein kinase a mediates activity-dependent Kv4.2 channel trafficking. J Neurosci 28, 7513-9
18650329   Curated Info

4

Shibata R, et al. (2003) A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem 278, 36445-54
12829703   Curated Info