Tyr336
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr336  -  TGFBR2 (human)

Site Information
AKGNLQEyLTRHVIS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2869603

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 2 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ITGA1 (human) ( 1 )
Kinases, in vitro:
TGFBR2 (human) ( 3 )
Phosphatases, in vitro:
PTPN2 (human) ( 1 )
Treatments:
hypertonic_buffer ( 2 )

Downstream Regulation
Effects of modification on TGFBR2:
activity, induced ( 1 ) , enzymatic activity, induced ( 3 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, altered ( 3 )

References 

1

Chen X, et al. (2014) Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest 124, 3295-310
24983314   Curated Info

2

Chiang TA, et al. (2010) Hyperosmolarity enhanced susceptibility to renal tubular fibrosis by modulating catabolism of type I transforming growth factor-beta receptors. J Cell Biochem 109, 663-71
20091742   Curated Info

3

Lawler S, et al. (1997) The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. J Biol Chem 272, 14850-9
9169454   Curated Info