Ser185
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Home > Phosphorylation Site Page: > Ser185  -  RHOB (human)

Site Information
ALQKRYGsQNGCINC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2853110

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , medulloblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK1A (human) ( 2 )
Kinases, in vitro:
CK1A (human) ( 2 )
Treatments:
D4476 ( 2 ) , IC261 ( 2 )

Downstream Regulation
Effects of modification on RHOB:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 ) , endocytosis, induced ( 1 )
Inhibit interaction with:
PKN1 (human) ( 2 )

References 

1

Li C, et al. (2016) Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. Mol Cell Biol 36, 2596-611
27503856   Curated Info

2

Tillement V, et al. (2008) Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilization. Exp Cell Res 314, 2811-21
18590726   Curated Info