Ser492
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Home > Phosphorylation Site Page: > Ser492  -  PTHR (human)

Site Information
RKARsGsssySyGPM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2853102

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 ) , Jurkat (T lymphocyte) ( 3 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Treatments:
PTH ( 1 )

Downstream Regulation
Effects of modification on PTHR:
molecular association, regulation ( 2 ) , receptor internalization, induced ( 2 )
Induce interaction with:
ARR3 (human) ( 2 )

References 

1

Zhang Q, et al. (2018) Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation. J Biol Chem
29444827   Curated Info

2

Zindel D, et al. (2016) Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling. Biochem J 473, 4173-4192
27623777   Curated Info

3

Possemato A (2008) CST Curation Set: 3770; Year: 2008; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info