Ser138
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Home > Phosphorylation Site Page: > Ser138  -  profilin 1 (mouse)

Site Information
MAsHLRRsQY_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2850008

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
Huntington's disease ( 2 )
Relevant cell line - cell type - tissue:
'stem, neural' ( 1 ) , 3T3 (fibroblast) ( 3 ) , brain ( 1 ) , retina ( 2 )

Upstream Regulation
Treatments:
HA-1077 ( 2 ) , LPA ( 3 ) , Y27632 ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Baharani A, Wei Z, Roesler WJ, Mousseau DD (2020) A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington's Disease: Possible Sex-Dependent Signaling. Cell Mol Neurobiol
33108594   Curated Info

2

Li M, et al. (2013) Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease. PLoS One 8, e56026
23409115   Curated Info

3

Shao J, Diamond MI (2012) Protein phosphatase 1 dephosphorylates profilin-1 at ser-137. PLoS One 7, e32802
22479341   Curated Info