Ser862
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Home > Phosphorylation Site Page: > Ser862  -  mGluR7 (mouse)

Site Information
NVQKRKRsFKAVVTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2846504

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Regulatory protein:
PICK1 (mouse) ( 1 )
Putative in vivo kinases:
PKCA (mouse) ( 1 )
Kinases, in vitro:
PKCA (human) ( 1 )
Treatments:
chelerythrine ( 1 ) , KCl ( 1 ) , NMDA ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on mGluR7:
molecular association, regulation ( 1 ) , receptor internalization, altered ( 1 )
Induce interaction with:
PICK1 (mouse) ( 1 )
Inhibit interaction with:
Calmodulin (mouse) ( 1 )

References 

1

Suh YH, et al. (2008) Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. Neuron 58, 736-48
18549785   Curated Info