Ser80
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Home > Phosphorylation Site Page: > Ser80  -  TTK (human)

Site Information
EkNSVPLsDALLNkL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2846503

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mass spectrometry ( 1 , 3 , 4 , 5 , 7 , 8 ) , mass spectrometry (in vitro) ( 6 ) , mutation of modification site ( 2 , 6 )
Disease tissue studied:
colorectal cancer ( 2 , 6 ) , colorectal carcinoma ( 2 , 6 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 3 , 8 ) , HeLa S3 (cervical) ( 7 ) , HeLa_Meta (cervical) ( 4 ) , HeLa_Pro (cervical) ( 4 ) , HeLa_Telo (cervical) ( 4 ) , MDA-MB-435S (breast cell) ( 5 ) , SW480 (intestinal) ( 2 , 6 )

Upstream Regulation
Kinases, in vitro:
TTK (human) ( 6 , 8 )
Treatments:
MG132_withdrawal ( 4 ) , nocodazole ( 7 ) , thymidine ( 7 )

Downstream Regulation
Effects of modification on TTK:
intracellular localization ( 2 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Zhang X, et al. (2011) Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses. Cell Cycle 10, 2742-50
21778823   Curated Info

3

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

4

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

5

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

6

Xu Q, et al. (2009) Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell 20, 10-20
18923149   Curated Info

7

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

8

Jelluma N, et al. (2008) Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One 3, e2415
18545697   Curated Info