Ser112
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Home > Phosphorylation Site Page: > Ser112  -  MCM3 (mouse)

Site Information
SFGSKHVsPRTLTSC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2840507

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (mouse) ( 1 )
Kinases, in vitro:
CDK1 (human) ( 1 )
Treatments:
nocodazole ( 1 ) , seliciclib ( 1 )

Downstream Regulation
Effects of modification on MCM3:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )
Induce interaction with:
DNA ( 1 ) , MCM2 (mouse) ( 1 ) , MCM5 (mouse) ( 1 ) , MCM7 (mouse) ( 1 )

References 

1

Lin DI, Aggarwal P, Diehl JA (2008) Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex. Proc Natl Acad Sci U S A 105, 8079-84
18524952   Curated Info

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