Ser393
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Home > Phosphorylation Site Page: > Ser393  -  KCNK3 (human)

Site Information
GLMKRRssV______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2840504

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , oocyte ( 2 , 3 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 )
Kinases, in vitro:
PKACA (human) ( 2 ) , RSK2 (human) ( 2 )
Treatments:
cAMP_analog ( 2 ) , KT5720 ( 2 ) , PKI ( 2 )

Downstream Regulation
Effects of modification on KCNK3:
activity, induced ( 2 ) , intracellular localization ( 2 )

References 

1

Seyler C, et al. (2012) TASK1 (K(2P) 3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation. Br J Pharmacol 165, 1467-75
21838752   Curated Info

2

Mant A, Elliott D, Eyers PA, O'Kelly IM (2011) Protein Kinase A Is Central for Forward Transport of Two-pore Domain Potassium Channels K2P3.1 and K2P9.1. J Biol Chem 286, 14110-9
21357689   Curated Info

3

Gierten J, et al. (2008) Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. Br J Pharmacol 154, 1680-90
18516069   Curated Info