Ser266
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Home > Phosphorylation Site Page: > Ser266  -  GATA6 (human)

Site Information
VSARFPYsPsPPMAN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2833503

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 7 ) , mutation of modification site ( 6 ) , phosphoamino acid analysis ( 6 )
Disease tissue studied:
cervical cancer ( 2 ) , cervical adenocarcinoma ( 2 ) , colorectal cancer ( 6 ) , colorectal carcinoma ( 6 )
Relevant cell line - cell type - tissue:
Caco-2 (intestinal) ( 6 ) , HeLa (cervical) ( 1 , 3 , 4 , 5 , 7 ) , HeLa S3 (cervical) ( 2 )

Upstream Regulation
Regulatory protein:
HRas (human) ( 6 ) , MEK1 (human) ( 6 )
Putative in vivo kinases:
ERK1 (human) ( 6 ) , ERK2 (human) ( 6 )
Treatments:
PD98059 ( 6 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, altered ( 6 ) , transcription, induced ( 6 )

References 

1

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

2

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

3

Moritz A (2008) CST Curation Set: 5058; Year: 2008; Biosample/Treatment: cell line, HeLa/nocodazole; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

4

Moritz A (2008) CST Curation Set: 5059; Year: 2008; Biosample/Treatment: cell line, HeLa/nocodazole; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

5

Moritz A (2008) CST Curation Set: 5080; Year: 2008; Biosample/Treatment: cell line, HeLa/nocodazole; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

6

Adachi Y, et al. (2008) Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. Oncogene 27, 4921-32
18454176   Curated Info

7

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

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