Ser201
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Home > Phosphorylation Site Page: > Ser201  -  ROMK (human)

Site Information
FSKNAVIskRGGKLC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2813508

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , COS (fibroblast) ( 3 ) , oocyte ( 1 , 2 , 3 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 3 )

Downstream Regulation
Effects of modification on ROMK:
activity, induced ( 3 ) , intracellular localization ( 3 )

References 

1

Huang PT, Lee CH, Liou HH, Lou KL (2012) Protein kinase C mediated pH( i )-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism. J Mol Model 18, 2929-41
22139477   Curated Info

2

Lee CH, Lee CY, Tsai TS, Liou HH (2008) PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharmacol 76, 225-35
18547545   Curated Info

3

Lin D, et al. (2002) Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels. J Biol Chem 277, 44278-84
12221079   Curated Info

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