Ser4
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Home > Phosphorylation Site Page: > Ser4  -  ROMK (human)

Site Information
____MNAsSRNVFDT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2813507

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , COS (fibroblast) ( 2 ) , oocyte ( 1 , 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 2 )

Downstream Regulation
Effects of modification on ROMK:
activity, induced ( 2 ) , intracellular localization ( 2 )

References 

1

Lee CH, Lee CY, Tsai TS, Liou HH (2008) PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharmacol 76, 225-35
18547545   Curated Info

2

Lin D, et al. (2002) Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels. J Biol Chem 277, 44278-84
12221079   Curated Info