Thr193
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Home > Phosphorylation Site Page: > Thr193  -  ROMK (human)

Site Information
KKRAKtItFSKNAVI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2813503

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
oocyte ( 1 , 2 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Treatments:
GF109203X ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on ROMK:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Inhibit interaction with:
ROMK (human) ( 1 )

References 

1

Huang PT, Lee CH, Liou HH, Lou KL (2012) Protein kinase C mediated pH( i )-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism. J Mol Model 18, 2929-41
22139477   Curated Info

2

Lee CH, Lee CY, Tsai TS, Liou HH (2008) PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharmacol 76, 225-35
18547545   Curated Info