Tyr44
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.8.0
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr44  -  Tip60 (human)

Site Information
ISGRKLFyVHYIDFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 28132103

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 3 ) , WRD ( 1 )

Upstream Regulation
Regulatory protein:
Abi-1 (human) ( 3 ) , HP1 alpha (human) ( 3 )
Kinases, in vitro:
Abl (human) ( 3 )
Treatments:
imatinib ( 3 ) , ionizing_radiation ( 3 ) , okadaic_acid ( 3 ) , trichostatin_A ( 3 )

Downstream Regulation
Effects of modification on Tip60:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 2 , 3 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
cell cycle regulation ( 3 ) , DNA repair, induced ( 3 ) , transcription, induced ( 1 )
Induce interaction with:
AGO2 (human) ( 2 ) , DNA ( 3 ) , H3 (human) ( 3 )

References 

1

Zhang X, et al. (2024) NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac. J Virol 98, e0169523
38349085   Curated Info

2

Wang Q, Goldstein M (2016) Small RNAs Recruit Chromatin-Modifying Enzymes MMSET and Tip60 to Reconfigure Damaged DNA upon Double-Strand Break and Facilitate Repair. Cancer Res 76, 1904-15
26822153   Curated Info

3

Kaidi A, Jackson SP (2013) KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498, 70-4
23708966   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.