Tyr656
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr656  -  eNOS (mouse)

Site Information
FGLGSRAyPHFCAFA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2811400

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , carotid artery ( 2 ) , endothelial ( 1 ) , microvessel endothelial-lung ( 1 , 2 )

Upstream Regulation
Putative in vivo kinases:
Pyk2 (human) ( 2 )
Treatments:
angiotensin_2 ( 1 , 2 ) , H2O2 ( 1 ) , siRNA ( 2 ) , telmisartan ( 2 )

Downstream Regulation
Effects of modification on eNOS:
molecular association, regulation ( 1 )
Inhibit interaction with:
Calmodulin (mouse) ( 1 ) , HSP90A (mouse) ( 1 ) , PKM (mouse) ( 1 )

References 

1

Siragusa M, et al. (2019) Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition. EMBO J, e100938
31328803   Curated Info

2

Loot AE, Schreiber JG, Fisslthaler B, Fleming I (2009) Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. J Exp Med 206, 2889-96
19934023   Curated Info